Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Matthew Axtman"'
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library
Autor:
Devan J. Shell, Justin M. Rectenwald, Peter H. Buttery, Rebecca L. Johnson, Caroline A. Foley, Shiva K.R. Guduru, Mélanie Uguen, Juanita Sanchez Rubiano, Xindi Zhang, Fengling Li, Jacqueline L. Norris-Drouin, Matthew Axtman, P. Brian Hardy, Masoud Vedadi, Stephen V. Frye, Lindsey I. James, Kenneth H. Pearce
Publikováno v:
SLAS Discovery, Vol 27, Iss 8, Pp 428-439 (2022)
Methyl-lysine (Kme) reader domains are prevalent in chromatin regulatory proteins which bind post-translational modification sites to recruit repressive and activating factors; therefore, these proteins play crucial roles in cellular signaling and ep
Externí odkaz:
https://doaj.org/article/859446a01131470eb8e3880dae7658e0
Autor:
Katherine A. Abrahams, Chun-wa Chung, Sonja Ghidelli-Disse, Joaquín Rullas, María José Rebollo-López, Sudagar S. Gurcha, Jonathan A. G. Cox, Alfonso Mendoza, Elena Jiménez-Navarro, María Santos Martínez-Martínez, Margarete Neu, Anthony Shillings, Paul Homes, Argyrides Argyrou, Ruth Casanueva, Nicholas J. Loman, Patrick J. Moynihan, Joël Lelièvre, Carolyn Selenski, Matthew Axtman, Laurent Kremer, Marcus Bantscheff, Iñigo Angulo-Barturen, Mónica Cacho Izquierdo, Nicholas C. Cammack, Gerard Drewes, Lluis Ballell, David Barros, Gurdyal S. Besra, Robert H. Bates
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Screens for bactericidal compounds have resulted in promising anti-tubercular hits. Here, the authors analyse in detail the target of an indazole sulfonamide (GSK3011724A), and find that it has a different mode of inhibition compared to other Kas inh
Externí odkaz:
https://doaj.org/article/98e2a1212a5248b996b2c2ff78fce60e
Autor:
Lucy Ellis, Yumi Park, Ola Epemolu, Paul G. Wyatt, Stefano Donini, Laura E. Via, Carolyn Selenski, Matthew Axtman, Thomas R. Ioerger, Menico Rizzi, Tom L. Blundell, Nian Zhou, Simon Green, Olalla Sanz, Maria Osuna-Cabello, David B. Ascher, Helena I. Boshoff, Laste Stojanovski, Travis Hartman, Dale J. Kempf, Clifton E. Barry, Joël Lelièvre, Tracy Bayliss, Zhe Wang, Fred Simeons, Claire J. MacKenzie, Hannah Pflaumer, Valerie Mizrahi, Fabio Zuccotto, James C. Sacchettini, Gracia Santos Diaz, Véronique Dartois, Angela Pacitto, Susan Davis, Kyu Y. Rhee, Laura A. T. Cleghorn, Margaret Huggett, Matthew D. Kurnick, Dinakaran Murugesan, Penelope A. Turner, Kriti Arora, Gerard Drewes, Lluis Ballell, Markus Bösche, Gail M. Freiberg, Kevin D. Read, Surendranadha Reddy Jonnala, Kirsteen I. Buchanan, Maria Jose Lafuente-Monasterio, María José Rebollo-López, Sonja Ghidelli-Disse, Peter C. Ray, Alasdair Smith, Myron Srikumaran, Ardala Breda
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
A potent, noncytotoxic indazole sulfonamide was identified by high-throughput screening of >100,000 synthetic compounds for activity against Mycobacterium tuberculosis (Mtb). This noncytotoxic compound did not directly inhibit cell wall biogenesis bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896be08dd9046b3b0b9f82d81de880f5
https://doi.org/10.1021/acsinfecdis.6b00103
https://doi.org/10.1021/acsinfecdis.6b00103
Autor:
Robert H. Bates, Alfonso Mendoza, Joaquín Rullas, Joël Lelièvre, Chun Wa Chung, Ruth Casanueva, Sudagar S. Gurcha, Maria Santos Martinez-Martinez, Patrick J. Moynihan, Margarete Neu, Nicholas Cammack, Gurdyal S. Besra, Nicholas J. Loman, Jonathan A. G. Cox, Katherine A. Abrahams, Paul Homes, Marcus Bantscheff, Anthony Shillings, Gerard Drewes, Elena Jimenez-Navarro, Lluis Ballell, Matthew Axtman, Carolyn Selenski, Argyrides Argyrou, Monica Cacho Izquierdo, Iñigo Angulo-Barturen, Laurent Kremer, María José Rebollo-López, David Barros, Sonja Ghidelli-Disse
Publikováno v:
Nature Communications
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Phenotypic screens for bactericidal compounds are starting to yield promising hits against tuberculosis. In this regard, whole-genome sequencing of spontaneous resistant mutants generated against an indazole sulfonamide (GSK3011724A) identifies sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bc616023998dc8cdc5fc5ed68a4c7e
https://pubmed.ncbi.nlm.nih.gov/27581223
https://pubmed.ncbi.nlm.nih.gov/27581223
Autor:
John Mulcahy, David C. Yeomans, Justin Du Bois, George Miljanich, Sandip Biswal, Matthew Axtman
Publikováno v:
Toxicon. 60:112-113
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cad3e6740d86fa304fae71a502d22deb
https://doi.org/10.1016/j.toxicon.2012.04.036
https://doi.org/10.1016/j.toxicon.2012.04.036