Refinement of an ovine-based immunoglobulin therapy against SARS-CoV-2, with comparison of whole IgG versus F(ab′)2 fragments

Autor: Stephen Findlay-Wilson, Linda Easterbrook, Sandra Smith, Neville Pope, Matthew Aldridge, Gareth Humphries, Holger Schuhmann, Didier Ngabo, Emma Rayner, Ashley Otter, Thomas Coleman, Bethany Hicks, Rachel Halkerston, Kostis Apostolakis, Stephen Taylor, Susan Fotheringham, Amanda Horton, Irene CanoCejas, Matthew Wand, Julia A. Tree, Mark Sutton, Victoria Graham, Roger Hewson, Stuart Dowall

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract The development of new therapies against SARS-CoV-2 is required to extend the toolkit of intervention strategies to combat the global pandemic. In this study, hyperimmune plasma from sheep immunised with whole spike SARS-CoV-2 recombinant pr

Externí odkaz: https://doaj.org/article/b6dbbe9b29a843fc82dd0a936c9ba647

Bridging the realism gap: using ‘low-fidelity’ simulation for high quality training

Autor: Peter Steed, Jolene Slothouber Galbreath, Matthew Aldridge

Publikováno v: International Journal of Healthcare Simulation.

The Royal College of Anaesthetists recommends use of simulation-based-education (SBE) during the initial 12-week novice placement for new anaesthetic trainees [1]. For many UK anaesthetic departments, the complexity and cost of patient simulators [2]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6333ee1301e42a49f2857cf0766cfaa
https://doi.org/10.54531/enyn6442

On the All-or-Nothing Behavior of Bernoulli Group Testing

Autor: Jonathan Scarlett, Lan V. Truong, Matthew Aldridge

In this paper, we study the problem of non-adaptive group testing, in which one seeks to identify which items are defective given a set of suitably-designed tests whose outcomes indicate whether or not at least one defective item was included in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191ccaef80c7d677b6206eb2be5dc519

Performance of Group Testing Algorithms With Near-Constant Tests Per Item

Autor: Matthew Aldridge, Jonathan Scarlett, Oliver Johnson

Publikováno v: Johnson, O, Aldridge, M P & Scarlett, J 2019, ' Performance of Group Testing Algorithms With Near-Constant Tests-per-Item ', IEEE Transactions on Information Theory, vol. 65, no. 2, 8423683, pp. 707-723 . https://doi.org/10.1109/TIT.2018.2861772

We consider the nonadaptive group testing with N items, of which $K = \Theta(N^\theta)$ are defective. We study a test design in which each item appears in nearly the same number of tests. For each item, we independently pick L tests uniformly at ran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f157f2cd190196b20b30d2d2dbfeaba
https://doi.org/10.1109/tit.2018.2861772

Access to community support workers during hospital admission for people with spinal cord injury: a pilot study

Autor: Ian Simpson, Matthew Aldridge, John A. Bourke, Joanne L. Nunnerley, Rachelle A Martin

Publikováno v: Spinal Cord Ser Cases

STUDY DESIGN: A descriptive qualitative study. OBJECTIVES: To evaluate a pilot project enabling people with spinal cord injury (SCI) to have their support workers accompany them into a non-SCI specialist/public hospital (excluding ICU) to perform sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943572b7ef437ea0e099faad9b602f28
https://doi.org/10.1038/s41394-020-00370-6