Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Matthew A. Zajac"'
Autor:
Andrew D. Campbell, Rubén Haro, Thomas Andrew Brandt, Melodie Christensen, David B. Damon, Ke Wang, Carolina Alhambra, Paul C. Lobben, Jacob M. Janey, J. Eugenio de Diego, Ling Li, Iulia I. Strambeanu, Susana García-Cerrada, Javier Magano, Emma McInturff, Steven M. Mennen, Jack Twilton, David W. C. MacMillan, Fangfang Liu, Jesús Castañón, Matthew A. Zajac, Pablo Garcia-Losada, Sebastien Monfette, Mario Barberis, Alan H. Cherney, Jason M. Stevens, Barbara J. Sitter, Danielle M. Schultz, Ronald J. Post, Simon Berritt, C. Liana Allen, David C. Leitch
Publikováno v:
Organic Process Research & Development. 23:1213-1242
High-throughput experimentation (HTE) has revolutionized the pharmaceutical industry, most notably allowing for rapid screening of compound libraries against therapeutic targets. The past decade ha...
Publikováno v:
Nature Catalysis. 2:2-4
Developing catalytic reactions for organic synthesis is the central goal of countless research groups worldwide. High-throughput experimentation is invaluable for this pursuit, with the requisite tools becoming increasingly available to both industri
Publikováno v:
Angewandte Chemie International Edition. 50:12335-12338
A practical procedure for the enantioselective reaction between α,β-unsaturated ketones and glycine imines is described using a FOXAP-type ferrocene as optimal ligand.
Autor:
Matthew A. Zajac, Edwin Vedejs
Publikováno v:
Organic Letters. 3:2451-2454
[reaction: see text] Suzuki coupling of 18 and 30 affords 9 as an interconverting mixture of two atropisomers. Treatment with LDA at -23 degrees C affords the macrocyclic ketone 8 in 57% yield.
Publikováno v:
ChemInform. 43
A practical procedure for the enantioselective reaction between α,β-unsaturated ketones and glycine imines is described using a FOXAP-type ferrocene as optimal ligand.
Autor:
Edwin Vedejs, Matthew A. Zajac
Publikováno v:
ChemInform. 32
Suzuki coupling of 18 and 30 affords 9 as an interconverting mixture of two atropisomers. Treatment with LDA at −23 °C affords the macrocyclic ketone 8 in 57% yield.
Autor:
Matthew A. Zajac
Publikováno v:
The Journal of organic chemistry. 73(17)
Efforts to couple 4 with 12 employing base mediation are problematic due to the formation of 6. To circumvent this issue, 12 was converted to the pyridine borane complex (13). Alkylation of 4 with 13 provided 3 after removal of the borane under acidi
Publikováno v:
ChemInform. 38
Two protocols for the transamidation of primary amides with primary and secondary amines, forming secondary and tertiary amides, respectively, are described. Both processes employ N,N-dialkylformamide dimethyl acetals for primary amide activation, pr
Publikováno v:
Journal of the American Chemical Society. 128(50)
Two protocols for the transamidation of primary amides with primary and secondary amines, forming secondary and tertiary amides, respectively, are described. Both processes employ N,N-dialkylformamide dimethyl acetals for primary amide activation, pr