Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Matthew A. Sleeman"'
Publikováno v:
Frontiers in Allergy, Vol 3 (2022)
Over the last 4 decades there has been a significant global increase in the incidence and prevalence of IgE-mediated allergy. Although much progress has been made in the management of allergy via patient education, pharmacotherapy and immunomodulator
Externí odkaz:
https://doaj.org/article/dc073749959d4d1585cb297b0084bfa5
Autor:
Jonas S. Erjefält, Natália de Souza Xavier Costa, Jimmie Jönsson, Olga Cozzolino, Katia Cristina Dantas, Carl-Magnus Clausson, Premkumar Siddhuraj, Caroline Lindö, Manar Alyamani, Suzete Cleusa Ferreira Spina Lombardi, Alfredo Mendroni Júnior, Leila Antonangelo, Caroline Silvério Faria, Amaro Nunes Duarte-Neto, Renata Aparecida de Almeida Monteiro, João Renato Rebello Pinho, Michele Soares Gomes-Gouvêa, Roberta Verciano Pereira, Jhonatas Sirino Monteiro, João Carlos Setubal, Ellen Pierre de Oliveira, Jair Theodoro Filho, Caroline Sanden, Jamie M. Orengo, Matthew A. Sleeman, Luiz Fernando Ferraz da Silva, Paulo Hilário Nascimento Saldiva, Marisa Dolhnikoff, Thais Mauad
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104229- (2022)
Summary: Background: Severe COVID-19 lung disease exhibits a high degree of spatial and temporal heterogeneity, with different histological features coexisting within a single individual. It is important to capture the disease complexity to support p
Externí odkaz:
https://doaj.org/article/19c5eb08a3f74639b055f0a03c0a2cf5
Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes
Autor:
Casandra Panea, Ruoyu Zhang, Jeffrey VanValkenburgh, Min Ni, Christina Adler, Yi Wei, Francisca Ochoa, Jennifer Schmahl, Yajun Tang, Chia-Jen Siao, William Poueymirou, Jennifer Espert, Wei Keat Lim, Gurinder S. Atwal, Andrew J. Murphy, Matthew A. Sleeman, Zaruhi Hovhannisyan, Sokol Haxhinasto
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Panea et al showed that epithelia-specific butyrophilinlike 2 (Btnl2) suppressed homeostatic proliferation of γδ intraepithelial lymphocytes (IELs) preferentially in the ileum and used high throughput transcriptomic characterization of Btnl2-defici
Externí odkaz:
https://doaj.org/article/76b2722c8a4148d38819e67926137016
Autor:
Xuan Ye, Janelle C. Waite, Ankur Dhanik, Namita Gupta, Maggie Zhong, Christina Adler, Evangelia Malahias, Min Ni, Yi Wei, Cagan Gurer, Wen Zhang, Lynn E. Macdonald, Andrew J. Murphy, Matthew A. Sleeman, Dimitris Skokos
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Clinical observations suggest that responses to cancer immunotherapy are correlated with intra-tumoral T cell receptor (TCR) clonality, tumor mutation burden (TMB) and host HLA genotype, highlighting the importance of host T cell recognition of tumor
Externí odkaz:
https://doaj.org/article/e5e01689ac6541e6844a8430c0033c6b
Autor:
Lynne A. Murray, Rebecca Dunmore, Ana Camelo, Carla A. Da Silva, Malin J. Gustavsson, David M. Habiel, Tillie L Hackett, Cory M. Hogaboam, Matthew A. Sleeman, Darryl A. Knight
Publikováno v:
Respiratory Research, Vol 18, Iss 1, Pp 1-12 (2017)
Abstract Background Smoking and aberrant epithelial responses are risk factors for lung cancer as well as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. In these conditions, disease progression is associated with epithelial
Externí odkaz:
https://doaj.org/article/40130925c55a4bc29eb4f09272bb4f31
Autor:
Ana Camelo, Guglielmo Rosignoli, Yoichiro Ohne, Ross A. Stewart, Catherine Overed-Sayer, Matthew A. Sleeman, Richard D. May
Publikováno v:
Blood Advances, Vol 1, Iss 10, Pp 577-589 (2017)
Abstract: Innate lymphoid cells (ILCs) represent a distinct branch of the lymphoid lineage composed of 3 major subpopulations: ILC1, ILC2, and ILC3. ILCs are mainly described as tissue-resident cells but can be detected at low levels in human blood.
Externí odkaz:
https://doaj.org/article/d2bd093d25c0440a9375db587595ccd6
Autor:
Jennifer Cable, Erica Ollmann Saphire, Adrian C. Hayday, Timothy D. Wiltshire, Jarrod J. Mousa, David P. Humphreys, Esther C. W. Breij, Pierre Bruhns, Matteo Broketa, Genta Furuya, Blake M. Hauser, Matthieu Mahévas, Andrea Carfi, Tineke Cantaert, Peter D. Kwong, Prabhanshu Tripathi, Jonathan H. Davis, Neil Brewis, Bruce A. Keyt, Felix L. Fennemann, Vincent Dussupt, Arvind Sivasubramanian, Philip M. Kim, Reda Rawi, Eve Richardson, Daniel Leventhal, Rachael M. Wolters, Cecile A. W. Geuijen, Matthew A. Sleeman, Niccolo Pengo, Francesca Rose Donnellan
Publikováno v:
Annals of the New York Academy of Sciences. 1519:153-166
Therapeutic antibodies have broad indications across diverse disease states, such as oncology, autoimmune diseases, and infectious diseases. New research continues to identify antibodies with therapeutic potential as well as methods to improve upon e
Autor:
Audrey Le Floc’h, Kirsten Nagashima, Dylan Birchard, George Scott, Li-Hong Ben, Dharani Ajithdoss, Kaitlyn Gayvert, Annabel Romero Hernandez, Olivier Herbin, Amanda Tay, Pamela Farrales, Chandrashekhar K. Korgaonkar, Hao Pan, Sweta Shah, Vishal Kamat, Ishita Chatterjee, Jon Popke, Adelekan Oyejide, Wei Keat Lim, Jee H. Kim, Tammy Huang, Matthew Franklin, William Olson, Thomas Norton, Lorah Perlee, George D. Yancopoulos, Andrew J. Murphy, Matthew A. Sleeman, Jamie M. Orengo
Publikováno v:
Science Translational Medicine. 15
The common γ chain (γc; IL-2RG) is a subunit of the interleukin (IL) receptors for the γc cytokines IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The lack of appropriate neutralizing antibodies recognizing IL-2RG has made it difficult to thoroughly in
Autor:
Katerina Koether, Valérie Besnard, Hilary Sandig, Alan Carruthers, Elena Miranda, Sabine Grootenboer-Mignot, Camille Taillé, Sylvie Chevret, Dominique Valeyre, Hilario Nunes, Dominique Israel-Biet, Wei Keat Lim, Vincent Cottin, Dominic Corkill, Claire Dobson, Maria Groves, Franco Ferraro, Edouard Guenzi, Ling Huang, Michal Sulikowski, Arnaud Mailleux, Lynne Anne Murray, Thomas Mustelin, Ian Strickland, Matthew A. Sleeman, Bruno Crestani
Publikováno v:
European Respiratory Journal. 61:2102381
Several reports have highlighted a potential role of autoreactive B-cells and autoantibodies that correlates with increased disease severity in patients with idiopathic pulmonary fibrosis (IPF). Here we show that patients with IPF have an altered B-c
Autor:
George Scott, Seblewongel Asrat, Jeanne Allinne, Wei Keat Lim, Kirsten Nagashima, Dylan Birchard, Subhashini Srivatsan, Dharani K. Ajithdoss, Adelekan Oyejide, Li-Hong Ben, Johnathon Walls, Audrey Le Floc'h, George D. Yancopoulos, Andrew J. Murphy, Matthew A. Sleeman, Jamie M. Orengo
Publikováno v:
Cytokine. 162:156091
Type 2 (T2) asthma is characterized by airflow limitations and elevated levels of blood and sputum eosinophils, fractional exhaled nitric oxide, IgE, and periostin. While eosinophils are associated with exacerbations, the contribution of eosinophils