Zobrazeno 1 - 10
of 621
pro vyhledávání: '"Matthew A. Silva"'
Autor:
Rajeev Aurora, Matthew J. Silva
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Immune cells play an important functional role in bone fracture healing. Fracture repair is a well-choreographed process that takes approximately 21 days in healthy mice. While the process is complex, conceptually it can be divided into four overlapp
Externí odkaz:
https://doaj.org/article/c021d93a8e014e15bb5fab3ed21a38c8
Publikováno v:
Frontiers in Physiology, Vol 13 (2023)
Murine models of long-bone fracture, stress fracture, and cortical defect are used to discern the cellular and molecular mediators of intramembranous and endochondral bone healing. Previous work has shown that Osterix (Osx+) and Dentin Matrix Protein
Externí odkaz:
https://doaj.org/article/6e4b7e79b41e41079e73041107f7727b
Publikováno v:
Bone Reports, Vol 17, Iss , Pp 101615- (2022)
Introduction: Knowledge of bone structure-function relationships in mice has been based on relatively small sample sets that limit generalizability. We sought to investigate structure-function relationships of long bones from a large population of ge
Externí odkaz:
https://doaj.org/article/797464590eae4827812ee6b482256b7a
Autor:
Katherine R. Hixon, Dakota B. Katz, Jennifer A. McKenzie, Anna N. Miller, Farshid Guilak, Matthew J. Silva
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Non-union is defined as the permanent failure of a bone to heal and occurs clinically in 5% of fractures. Atrophic non-unions, characterized by absent/minimal callus formation, are poorly understood and difficult to treat. We recently demonstrated a
Externí odkaz:
https://doaj.org/article/483f220f3d2943c89f50129305aa0a24
Autor:
Taylor L. Harris, Matthew J. Silva
Publikováno v:
JBMR Plus, Vol 6, Iss 3, Pp n/a-n/a (2022)
ABSTRACT Previous work has shown that osteoprogenitor cells (Prx1+) and pre‐osteoblasts (Osx+) contribute to mechanical loading‐induced bone formation. However, the role of mature Dmp1‐expressing osteoblasts has not been reported. In this study
Externí odkaz:
https://doaj.org/article/ee2fd3ea1a894db7af95b5f93c600200
Autor:
Kai Sun, Chun Wang, Jianqiu Xiao, Michael D Brodt, Luorongxin Yuan, Tong Yang, Yael Alippe, Huimin Hu, Dingjun Hao, Yousef Abu-Amer, Matthew J Silva, Jie Shen, Gabriel Mbalaviele
Publikováno v:
eLife, Vol 11 (2022)
Amino-terminal fragments from proteolytically cleaved gasdermins (GSDMs) form plasma membrane pores that enable the secretion of interleukin-1β (IL-1β) and IL-18. Excessive GSDM-mediated pore formation can compromise the integrity of the plasma mem
Externí odkaz:
https://doaj.org/article/7ca9264616784893a0c9e2f16bce0ef6
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Skeletal progenitors in postnatal mice are highly heterogeneous. Using lineage tracing and RNA-seq the authors show that Gli1+ cells give rise to all osteoblasts in mice, including those required for healing of bone fractures.
Externí odkaz:
https://doaj.org/article/2e832ba4b2fa485480ba446d775d50b6
Autor:
Heather M Zannit, Matthew J Silva
Publikováno v:
JBMR Plus, Vol 3, Iss 11, Pp n/a-n/a (2019)
ABSTRACT Mechanical loading stimulates bone formation. Bone‐lining‐cell activation and cell proliferation have been implicated in this process. However, the origin of osteoblasts that form bone following mechanical stimulation remains unknown. Ou
Externí odkaz:
https://doaj.org/article/49209e97f3a246d29233ca31034787d7
Publikováno v:
eLife, Vol 8 (2019)
Mechanical loading, such as caused by exercise, stimulates bone formation by osteoblasts and increases bone strength, but the mechanisms are poorly understood. Osteocytes reside in bone matrix, sense changes in mechanical load, and produce signals th
Externí odkaz:
https://doaj.org/article/82f9104b7d27429db877677ba7dd57ab
Autor:
Wei Zou, Nidhi Rohatgi, Jonathan R Brestoff, Yan Zhang, Erica L Scheller, Clarissa S Craft, Michael D Brodt, Nicole Migotsky, Matthew J Silva, Charles A Harris, Steven L Teitelbaum
Publikováno v:
PLoS Genetics, Vol 15, Iss 6, p e1008244 (2019)
Berardinelli-Seip congenital generalized lipodystrophy is associated with increased bone mass suggesting that fat tissue regulates the skeleton. Because there is little mechanistic information regarding this issue, we generated "fat-free" (FF) mice c
Externí odkaz:
https://doaj.org/article/3f85769dcd8146f293a5b9cf73c78f3b