Výsledky vyhledávání - "Matthew A. Sills"

Further Comparison of Primary Hit Identification by Different Assay Technologies and Effects of Assay Measurement Variability

Autor: Matthew A. Sills, Xiang Wu, Ji-Hu Zhang

Publikováno v: SLAS Discovery. 10:581-589

High-throughput screening (HTS) has grown rapidly in the past decade, with many advances in new assay formats, detection technologies, and laboratory automation. Recently, several studies have shown that the choice of assay technology used for the sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9e29df460b74c7f871b869ffb9e36a
https://doi.org/10.1177/1087057105275628

Zobrazit plný text záznamu

Identification of a High-Affinity Anti-Phosphoserine Antibody for the Development of a Homogeneous Fluorescence Polarization Assay of Protein Kinase C

Autor: Donna R. Yarwood, Quynhchi Pham, Matthew A. Sills, Jinzi J. Wu

Publikováno v: SLAS Discovery. 5:23-30

In the last few years, fluorescence polarization (FP) has been applied to the development of robust, homogeneous, high throughput assays in molecular recognition research, such as ligand-protein interactions. Recently, this technology has been applie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d35ad593f5ec37ad4620bc1d0a4d26
https://doi.org/10.1177/108705710000500106

Zobrazit plný text záznamu

Future considerations in HTS: the acute effect of chronic dilemmas

Autor: Matthew A. Sills

Publikováno v: Drug Discovery Today. 3:304-312

Today, in the area of Biomolecular Screening, it would seem that `something better' in terms of instrumentation or assay technology, is emerging almost every week. From the standpoint of planning, this presents significant challenges to decide whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85ba6ef63615a3eeed0dd67536c71b70
https://doi.org/10.1016/s1359-6446(98)01202-1

Zobrazit plný text záznamu

Application of Scintillating Microtiter Plates to Measure Phosphopeptide Interactions with the GRB2-SH2 Binding Domain

Autor: Albert F. Braunwalder, Lawrence Wennogle, Brigitte Gay, Kenneth E. Lipson, Matthew A. Sills

Publikováno v: SLAS Discovery. 1:23-26

A solid-phase assay to evaluate interactions with the GRB-SH2 domain is described. The method is based on the binding of a radio-iodinated 13 amino acid phosphopeptide flanking Y1068 of the EGF receptor to the SH2 domain attached to the surface of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2dc6cac6f4f88bbac78b843b65653659
https://doi.org/10.1177/108705719600100110

Zobrazit plný text záznamu

Isolation and structure elucidation of perthamide B, a novel peptide from the sponge Theonella sp

Autor: Shirley A. Pomponi, N. K. Gulavita, D. Yarwood, Amy E. Wright, Matthew A. Sills

Publikováno v: Tetrahedron Letters. 35:6815-6818

A sponge of the genus Theonella collected off Perth, Australia, contained a cyclic octapeptide, perthamide B, which weakly inhibited the binding of [125I]IL-1β to intact EL4.6.1 cells with an IC50 of 27.6 μM. The inhibition of binding could however

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c18939a3d556b92b0d64dbfd92acca5
https://doi.org/10.1016/0040-4039(94)85012-7

Zobrazit plný text záznamu

In vitro screens and functional assays to assess receptor pharmacology

Autor: Matthew A. Sills

Publikováno v: Drug Development Research. 32:260-268

In the drug discovery process, compounds that demonstrate therapeutic potential must be free of undesirable side effects in order to reach the clinic. Compounds that interact with more than one target, such as a receptor, have the potential to elicit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e726073c1a88ee1d4843243a5aa0a116
https://doi.org/10.1002/ddr.430320411

Zobrazit plný text záznamu

Eryloside E from an atlantic sponge Erylus goffrilleri

Autor: Michelle Kelly-Borges, Donna R. Yarwood, Nanda K. Gulavita, Amy E. Wright, Matthew A. Sills, Ross E. Longley

Publikováno v: Tetrahedron Letters. 35:4299-4302

A glycoside, which we call eryloside E ( 1 ), was isolated from the marine sponge Erylus goffrilleri and characterized by spectroscopic methods. Eryloside E possesses a rare penasterol nucleus with a t -butyl substituent on the side chain and three s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e283bc8d0a99139382372c30ab681409
https://doi.org/10.1016/s0040-4039(00)73338-7

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání