Výsledky vyhledávání - "Matthew A. Leff"

Effect of nucleotide substitutions in N-acetyltransferase-1 on N-acetylation (deactivation) and O-acetylation (activation) of arylamine carcinogens: implications for cancer predisposition

Autor: Mark A. Doll, David W. Hein, Yuanqi Zhu, Leo Smith, Adrian J. Fretland, Matthew A. Leff

Publikováno v: Cancer Detection and Prevention. 26:10-14

Genetic polymorphism in N -acetyltransferase-1 ( NAT1 ) is associated with increased risk of various cancers, but epidemiological investigations are compromised by poor understanding of the relationship between NAT1 genotype and phenotype. Human refe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd704c7a39fb8a97a261d6f8d6ca390
https://doi.org/10.1016/s0361-090x(02)00005-3

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Association of prostate cancer with rapidN-acetyltransferase 1 (NAT1*10) in combination with slowN-acetyltransferase 2 acetylator genotypes in a pilot case-control study

Autor: Martin C. Weinrich, Neil E. Caporaso, Rashmi Sinha, Naoko Ishibe, Mark A. Doll, Matthew A. Leff, Gong H. Xiao, Harold A. Frazier, David W. Hein

Publikováno v: Environmental and Molecular Mutagenesis. 40:161-167

N-acetyltransferase-1 (NAT1) and N-acetyltransferase-2 (NAT2) are important in the metabolism of aromatic and heterocyclic amine carcinogens that induce prostate tumors in the rat. We investigated the association of genetic polymorphisms in NAT1 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e975d7af496d9c0c2bdb0230b697fb18
https://doi.org/10.1002/em.10103

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Functional characterization of nucleotide polymorphisms in the coding region of N-acetyltransferase 1

Autor: Mark A. Doll, David W. Hein, Matthew A. Leff, Adrian J. Fretland

Publikováno v: Pharmacogenetics. 11:511-520

N-acetyltransferase 1 (NAT1) catalyses the activation and/or deactivation of aromatic and heterocyclic amine carcinogens. A genetic polymorphism in NAT1 is associated with an increased risk of various cancers and drug toxicities, but epidemiological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b816fcb1f82d36de0361a4bb184c14b8
https://doi.org/10.1097/00008571-200108000-00006

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DNA adduct levels and absence of tumors in female rapid and slow acetylator congenic hamsters administered the rat mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

Autor: Norma A. Nangju, Mark A. Doll, Gong H. Xiao, David W. Hein, Adrian J. Fretland, Uday S. Devanaboyina, Matthew A. Leff, Stephanie J. Webb

Publikováno v: Journal of Biochemical and Molecular Toxicology. 15:26-33

N-acetyltransferases (EC 2.3.1.5) catalyze O-acetylation of heterocyclic amine carcinogens to DNA-reactive electrophiles that bind and mutate DNA. An acetylation polymorphism exists in humans and Syrian hamsters regulated by N-acetyltransferase-2 (NA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a35d7597ce61f26b84aaefae91f5124
https://doi.org/10.1002/1099-0461(2001)15:1<26::aid-jbt3>3.0.co

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Novel Human N-Acetyltransferase 2 Alleles That Differ in Mechanism for Slow Acetylator Phenotype

Autor: Mark A. Doll, David W. Hein, Matthew A. Leff, Adrian J. Fretland

Publikováno v: Journal of Biological Chemistry. 274:34519-34522

Three novel human NAT2 alleles (NAT2*5D, NAT2*6D, and NAT2*14G) were identified and characterized in a yeast expression system. The common rapid (NAT2*4) and slow (NAT2*5B) acetylator human NAT2 alleles were also characterized for comparison. The nov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c952d8ff56901d0247582ce73f09b3ae
https://doi.org/10.1074/jbc.274.49.34519

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Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms

Autor: Adrian J. Fretland, Matthew A. Leff, Mark A. Doll, David W. Hein

Publikováno v: Pharmacogenetics. 11(3)

N-Acetyltransferase 2 (NAT2) catalyses the activation and/or deactivation of a variety of aromatic amine drugs and carcinogens. Polymorphisms in the N-acetyltransferase 2 (NAT2) gene have been associated with a variety of drug-induced toxicities, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131d8bd03cbba35ceb72d693856cdf93
https://pubmed.ncbi.nlm.nih.gov/11337936

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