Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Matthew A. Kennedy"'
Autor:
John W. Kennedy, Elliot J. Rooney, Paul J. Ryan, Soorya Siva, Matthew J. Kennedy, Ben Wheelwright, David Young, R. M. D. Meek
Publikováno v:
Bone & Joint Open, Vol 5, Iss 6, Pp 452-456 (2024)
Aims: Femoral periprosthetic fractures are rising in incidence. Their management is complex and carries a high associated mortality. Unlike native hip fractures, there are no guidelines advising on time to theatre in this group. We aim to determine w
Externí odkaz:
https://doaj.org/article/21db46b02ba84365b8b400d3c7b6c0ff
Autor:
Catherine Weathered, Sophia Bardehle, Choya Yoon, Niyanta Kumar, Cheryl E. G. Leyns, Matthew E. Kennedy, Peter Bloomingdale, Elsje Pienaar
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 3, Pp 449-463 (2024)
Abstract Alzheimer's disease (AD) is characterized by beta‐amyloid (Aβ) plaques in the brain and widespread neuronal damage. Because of the high drug attrition rates in AD, there is increased interest in characterizing neuroimmune responses to Aβ
Externí odkaz:
https://doaj.org/article/15e39054b039415a96117e3e3217cfcb
Autor:
Cheryl E. G. Leyns, Alice Prigent, Brenna Beezhold, Lihang Yao, Nathan G. Hatcher, Peining Tao, John Kang, EunRan Suh, Vivianna M. Van Deerlin, John Q. Trojanowski, Virginia M. Y. Lee, Matthew E. Kennedy, Matthew J. Fell, Michael X. Henderson
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases characterized by the accumulation of misfolded α-synuclein in the form of Lewy pathology. While most cases are sporadic, there are rar
Externí odkaz:
https://doaj.org/article/ffdac8823595475f8729dc4c771b2777
Autor:
Samantha S. Olah, Dean J. Kareemo, William C. Buchta, Brooke L. Sinnen, Carley N. Miller, Hannah S. Actor-Engel, Sara E. Gookin, Christina S. Winborn, Mason S. Kleinjan, Kevin C. Crosby, Jason Aoto, Katharine R. Smith, Matthew J. Kennedy
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113331- (2023)
Summary: Neurotransmitter receptors partition into nanometer-scale subdomains within the postsynaptic membrane that are precisely aligned with presynaptic neurotransmitter release sites. While spatial coordination between pre- and postsynaptic elemen
Externí odkaz:
https://doaj.org/article/3444965cf8894b45b28692c79eca5faf
Autor:
Stephan A. Müller, Merav D. Shmueli, Xiao Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-20 (2023)
Abstract Background The protease BACE1 is a major drug target for Alzheimer’s disease, but chronic BACE1 inhibition is associated with non-progressive cognitive worsening that may be caused by modulation of unknown physiological BACE1 substrates. M
Externí odkaz:
https://doaj.org/article/7fa094553b0842b2823d05e839ed3787
Autor:
Justyna A. Dobrowolska Zakaria, Randall J. Bateman, Monika Lysakowska, Ammaarah Khatri, Dinorah Jean-Gilles, Matthew E. Kennedy, Robert Vassar
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Evidence suggests that β-secretase (BACE1), which cleaves Amyloid Precursor Protein (APP) to form sAPPβ and amyloid-β, is elevated in Alzheimer's disease (AD) brains and biofluids and, thus, BACE1 is a therapeutic target for this devastat
Externí odkaz:
https://doaj.org/article/e920bdebd0534dcca97073affc0fb225
Autor:
Harrison J. Ramsay, Sara E. Gookin, Austin M. Ramsey, Dean J. Kareemo, Kevin C. Crosby, Dominik G. Stich, Samantha S. Olah, Hannah S. Actor-Engel, Katharine R. Smith, Matthew J. Kennedy
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Postsynaptic neurotransmitter receptors and their associated scaffolding proteins assemble into discrete, nanometer-scale subsynaptic domains (SSDs) within the postsynaptic membrane at both excitatory and inhibitory synapses. Intriguingly, postsynapt
Externí odkaz:
https://doaj.org/article/0a611978cc574cd884372c1cb950f914
Publikováno v:
Bone & Joint Open, Vol 3, Iss 3, Pp 218-228 (2022)
Aims Our objective was to conduct a systematic review and meta-analysis, to establish whether differences arise in clinical outcomes between autologous and synthetic bone grafts in the operative management of tibial plateau fractures. Methods A struc
Externí odkaz:
https://doaj.org/article/c28c550da1dc4de885e06939d012df1f
Autor:
Glyndwr W. Jenkins, Muhammad S. Iqbal, Nicholas West, Zoe Davidson, Matthew P. Kennedy, James R. Adams
Publikováno v:
Advances in Oral and Maxillofacial Surgery, Vol 8, Iss , Pp 100342- (2022)
Osteoradionecrosis of the mandible represents a cohort of patients that are notoriously difficult to treat. Complications are commonplace following free tissue transfer reconstructive surgery, including non-osseous union at the osteotomy site.We retr
Externí odkaz:
https://doaj.org/article/80570452f6cb423fb050928bac97e5d5
Autor:
Sara E. Gookin, Matthew R. Taylor, Samantha L. Schwartz, Matthew J. Kennedy, Mark L. Dell’Acqua, Kevin C. Crosby, Katharine R. Smith
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
The nanoscale architecture of synapses has been investigated using multiple super-resolution methods, revealing a common modular structure for scaffolds, neurotransmitter receptors, and presynaptic proteins. This fundamental organization of proteins
Externí odkaz:
https://doaj.org/article/ce3db4c3150a42509ceaf51515256aad