Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Matthew A. J. Duncton"'
Autor:
David M. Wilson, Matthew A. J. Duncton, Caleb Chang, Christie Lee Luo, Taxiarchis M. Georgiadis, Patricia Pellicena, Ashley M. Deacon, Yang Gao, Debanu Das
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Polymerase eta (or Pol η or POLH) is a specialized DNA polymerase that is able to bypass certain blocking lesions, such as those generated by ultraviolet radiation (UVR) or cisplatin, and is deployed to replication foci for translesion synthesis as
Externí odkaz:
https://doaj.org/article/40bb23ee3ada4b41a46d7f5aa6c07ebc
Autor:
Matthew A. J. Duncton, Brian J Wang
Publikováno v:
The Journal of Organic Chemistry. 85:13317-13323
The azetidine group is frequently encountered within contemporary medicinal chemistry. However, the introduction of an azetidine can be synthetically challenging. Herein, a straightforward synthesis of azetidine-3-amines, starting from a bench stable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4037c9d23f71e25cab09ba2eeec7ce
https://doi.org/10.1021/acs.joc.0c01831
https://doi.org/10.1021/acs.joc.0c01831
Autor:
Kavita Y. Sarin, John Kincaid, Brittney Sell, Jahanbanoo Shahryari, Matthew A. J. Duncton, Elaine Morefield, Wenchao Sun, Omar Chavez-Chiang, Scott R. Plotkin, Gerd G. Kochendoerfer, Peter Fenn, Christopher Powala, Kenneth Y. Tsai
Publikováno v:
Cancer Prevention Research. 15:A021-A021
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer comprising at least 20% of all non-melanoma skin cancers. While cSCC contributes to significant morbidity and mortality in high-risk individuals, deployment of otherwise e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e11261d2ad18d0ad4cb7a31ae551eee
https://doi.org/10.1158/1940-6215.tacpad22-a021
https://doi.org/10.1158/1940-6215.tacpad22-a021
Autor:
John A. Tainer, Davide Moiani, Ashley M. Deacon, Millie M. Georgiadis, Matthew A. J. Duncton, Andrew P. Yeh, Patricia Pellicena, Andrew S. Arvai, David M. Wilson, Debanu Das
Publikováno v:
Progress in biophysics and molecular biology
Cancer will directly affect the lives of over one-third of the population. The DNA Damage Response (DDR) is an intricate system involving damage recognition, cell cycle regulation, DNA repair, and ultimately cell fate determination, playing a central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2907db155d8a91d57edcb2e66d86b79e
https://escholarship.org/uc/item/00q4j9tj
https://escholarship.org/uc/item/00q4j9tj
Autor:
Millie M. Georgiadis, Ashley M. Deacon, Debanu Das, Matthew A. J. Duncton, Patricia Pellicena, David M. Wilson
Publikováno v:
Proceedings of The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response.
Cancer cells respond to increases in DNA damage by upregulating their DNA damage response (DDR). The base excision repair (BER) pathway corrects damage to single DNA bases through the action of multiple enzymes, including the central protagonist, apu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d10a28491ae27d9fc7ca1c603ab1d6d7
https://doi.org/10.3390/iecc2021-09201
https://doi.org/10.3390/iecc2021-09201
Autor:
Millie M. Georgiadis, Ashley M. Deacon, Matthew A. J. Duncton, Patricia Pellicena, Debanu Das, David M. Wilson
Publikováno v:
Journal of Clinical Oncology. 39:e15036-e15036
e15036 Background: Cancer cells respond to increases in DNA damage by deploying their DNA damage response (DDR) pathways. We are building a platform for the discovery and development of target-specific DDR therapeutics, including small molecule inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46f9af19986f314cd371d28ed87f3ebd
https://doi.org/10.1200/jco.2021.39.15_suppl.e15036
https://doi.org/10.1200/jco.2021.39.15_suppl.e15036
Autor:
Weitao Pan, Dan Sherman, Raphael Rios, Sang-phyo Hong, Farah Dhun, Matthew A. J. Duncton, Marc Labelle, Hai-Ying He, Mélissa Arbour, Yong-Jiang Xu, Hu Liu, Joel Kawakami
Publikováno v:
Tetrahedron Letters. 48:8943-8946
Differential reactivity of the amine functionality in a number of common 1,2-diamine starting materials is exploited to undertake an expedient synthesis of unsymmetrical 2,3,6-trisubstituted quinoxaline and unsymmetrical 2,3,7-trisubstituted pyridopy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d9005c303036bb3c81fdb5ed334ad98
https://doi.org/10.1016/j.tetlet.2007.10.117
https://doi.org/10.1016/j.tetlet.2007.10.117
Autor:
Evgueni L. Piatnitski, Andrey Konovalov, Leon M. Smith, Daniel L. Milligan, Matthew A. J. Duncton, Sabina Burdzovic-Wizemann, Ki H. Kim, Yaron R. Hadari, Chris Balagtas, Alexander S. Kiselyov, John Columbus, Wai C. Wong, Yong-Jiang Xu, Jacqueline Doody, Sui Ping Lee, Ying Wang, Robin L. Rosler, Yunyu Mao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5102-5106
Novel tricyclic derivatives containing an oxazepine, thiazepine, or diazepine ring were studied for their EGFR tyrosine kinase inhibitory activity. While the oxazepines were in general more potent than thiazepines, the diazepines displayed somewhat d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f720430f8a22f885cea8b0d67cf63359
https://doi.org/10.1016/j.bmcl.2006.07.031
https://doi.org/10.1016/j.bmcl.2006.07.031
Autor:
Leon M. Smith, Yong-Jiang Xu, Wai C. Wong, Yunyu Mao, Sabina Burdzovic-Wizeman, Hu Liu, Weitao Pan, Matthew A. J. Duncton
Publikováno v:
Synthetic Communications. 36:347-354
An improved route for the preparation of highly functionalized 5,6‐dihydro‐pyrimido[4,5‐b][1,4]oxazepine 1a in multigram quantities was developed. This new methodology was highlighted by the proper methoxy disposition via a regioselective methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b8a6d99c29eb3647904ea9687e52570
https://doi.org/10.1080/00397910500377479
https://doi.org/10.1080/00397910500377479
Autor:
Matthew A. J. Duncton, Sabina Burdzovic-Wizeman, Alexander S. Kiselyov, Leon M. Smith, Hu Liu, Aaron C. Burns, Wai C. Wong, Yunyu Mao
Publikováno v:
The Journal of Organic Chemistry. 70:9629-9631
[Reaction: see text]. A synthesis of the title compounds, which have found use as inhibitors of certain receptor tyrosine kinases, was achieved using a Pictet-Spengler cyclization as a key step.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c6d73230c034b5b578b1520f894da6
https://doi.org/10.1021/jo051419g
https://doi.org/10.1021/jo051419g