Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Matthew A. Inlay"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The SARS-CoV-2 pandemic has brought to light the need for expedient diagnostic testing. Cost and availability of large-scale testing capacity has led to a lag in turnaround time and hindered contact tracing efforts, resulting in a further sp
Externí odkaz:
https://doaj.org/article/5b61e0d162cb41fd99ec7e0c751830fe
Autor:
Alborz Karimzadeh, Erika S. Varady, Vanessa M. Scarfone, Connie Chao, Karin Grathwohl, Pauline U. Nguyen, Yasamine Ghorbanian, Irving L. Weissman, Thomas Serwold, Matthew A. Inlay
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Hematopoietic stem cells (HSCs) are defined by their self-renewal, multipotency, and bone marrow (BM) engraftment abilities. How HSCs emerge during embryonic development remains unclear, but are thought to arise from hemogenic endothelium through an
Externí odkaz:
https://doaj.org/article/8114c91a175f49768b4ae1f22a5838a5
Autor:
Mara Pavel-Dinu, Volker Wiebking, Beruh T. Dejene, Waracharee Srifa, Sruthi Mantri, Carmencita E. Nicolas, Ciaran Lee, Gang Bao, Eric J. Kildebeck, Niraj Punjya, Camille Sindhu, Matthew A. Inlay, Nivedita Saxena, Suk See DeRavin, Harry Malech, Maria Grazia Roncarolo, Kenneth I. Weinberg, Matthew H. Porteus
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Gene correction in hematopoietic stem cells could be a powerful way to treat monogenic diseases of the blood and immune system. Here the authors develop a strategy using CRISPR-Cas9 and an aAdeno-Associated vVirus(AAV)-delivered IL2RG cDNA to correct
Externí odkaz:
https://doaj.org/article/66cf921ac2ec4178bebe47ca77ff7c87
Autor:
Tannaz Faal, Duc T.T. Phan, Hayk Davtyan, Vanessa M. Scarfone, Erika Varady, Mathew Blurton-Jones, Christopher C.W. Hughes, Matthew A. Inlay
Publikováno v:
Stem Cell Reports, Vol 12, Iss 3, Pp 451-460 (2019)
Summary: In the CNS, perivascular cells (“pericytes”) associate with endothelial cells to mediate the formation of tight junctions essential to the function of the blood-brain barrier (BBB). The BBB protects the CNS by regulating the flow of nutr
Externí odkaz:
https://doaj.org/article/0e092644cfbf4f26b7ac105a3dd09594
Autor:
Mara Pavel-Dinu, Volker Wiebking, Beruh T. Dejene, Waracharee Srifa, Sruthi Mantri, Carmencita E. Nicolas, Ciaran Lee, Gang Bao, Eric J. Kildebeck, Niraj Punjya, Camille Sindhu, Matthew A. Inlay, Nivedita Saxena, Suk See DeRavin, Harry Malech, Maria Grazia Roncarolo, Kenneth I. Weinberg, Matthew H. Porteus
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/91a0613f85d54ca698128b995ca0d27f
Autor:
John W. Fathman, Nathaniel B. Fernhoff, Jun Seita, Connie Chao, Vanessa M. Scarfone, Irving L. Weissman, Matthew A. Inlay
Publikováno v:
Stem Cell Reports, Vol 3, Iss 5, Pp 707-715 (2014)
Small numbers of hematopoietic stem cells (HSCs) generate large numbers of mature effector cells through the successive amplification of transiently proliferating progenitor cells. HSCs and their downstream progenitors have been extensively character
Externí odkaz:
https://doaj.org/article/7e02cd0ebbf940d99dcfc889a631515f
Autor:
Matthew A. Inlay, Thomas Serwold, Adriane Mosley, John W. Fathman, Ivan K. Dimov, Jun Seita, Irving L. Weissman
Publikováno v:
Stem Cell Reports, Vol 2, Iss 4, Pp 457-472 (2014)
Hematopoiesis in the embryo proceeds in a series of waves, with primitive erythroid-biased waves succeeded by definitive waves, within which the properties of hematopoietic stem cells (multilineage potential, self-renewal, and engraftability) gradual
Externí odkaz:
https://doaj.org/article/168cbc8b8e9f48d6affdbf6f6b499f06
Publikováno v:
Scientific reports, vol 12, iss 1
The SARS-CoV-2 pandemic has brought to light the need for expedient diagnostic testing. Cost and availability of large-scale testing capacity has led to a lag in turnaround time and hindered contact tracing efforts, resulting in a further spread of S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25308a8006672a12b165b49e339f2151
https://escholarship.org/uc/item/6vh3v3sj
https://escholarship.org/uc/item/6vh3v3sj
Autor:
Lindsay A. Hohsfield, Kate I. Tsourmas, Yasamine Ghorbanian, Amber R. Syage, Sung Jin Kim, Yuting Cheng, Susana Furman, Matthew A. Inlay, Thomas E. Lane, Kim N. Green
Publikováno v:
Glia
Microglia are the primary resident myeloid cells of the brain responsible for maintaining homeostasis and protecting the central nervous system (CNS) from damage and infection. Monocytes and monocyte-derived macrophages arising from the periphery hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4dd4ebec069fdd19ee01e93cf9d5cb
https://pubmed.ncbi.nlm.nih.gov/35025109
https://pubmed.ncbi.nlm.nih.gov/35025109
Autor:
Lindsay A. Hohsfield, Ali Mortazavi, Sarah E Royer, Dario X. Figueroa Velez, Shan Jiang, Allison R. Najafi, Yasamine Ghorbanian, Matthew A. Inlay, Aileen J. Anderson, Neelakshi Soni, Sung Jin Kim, Joshua D. Crapser, Sunil P. Gandhi, Caden M Henningfield, Kim N. Green
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Microglia, the brain’s resident myeloid cells, play central roles in brain defense, homeostasis, and disease. Using a prolonged colony-stimulating factor 1 receptor inhibitor (CSF1Ri) approach, we report an unprecedented level of microglial depleti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494e7f221ff3405f2ebe416c402fec38
https://escholarship.org/uc/item/08q9p17d
https://escholarship.org/uc/item/08q9p17d