Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Matthew A. Hemphill"'
Autor:
Matthew A. Hemphill, David F. Meaney, David Issadore, Ramon Diaz-Arrastia, Kryshawna Beard, Melissa Schweizer, Jina Ko, Junhyong Kim, Jamie Shallcross, Danielle K. Sandsmark, Zijian Yang, Emily Sewell
Publikováno v:
J Neurotrauma
The diagnosis and prognosis of traumatic brain injury (TBI) is complicated by variability in the type and severity of injuries and the multiple endophenotypes that describe each patient's response and recovery to the injury. It has been challenging t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92912dc85b523731acae9508a425cecb
https://europepmc.org/articles/PMC7698852/
https://europepmc.org/articles/PMC7698852/
Dynamic neural and glial responses of a head-specific model for traumatic brain injury in Drosophila
Publikováno v:
Proc Natl Acad Sci U S A
Traumatic brain injury (TBI) is the strongest environmental risk factor for the accelerated development of neurodegenerative diseases. There are currently no therapeutics to address this due to lack of insight into mechanisms of injury progression, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b140066698a0fac852a45b2ee1ace5
https://europepmc.org/articles/PMC7382229/
https://europepmc.org/articles/PMC7382229/
Autor:
Janani Saikumar, Joshua Kim, Nancy M. Bonini, Matthew A. Hemphill, China N. Byrns, David F. Meaney
Drosophila models have been instrumental in providing insights into molecular mechanisms of neurodegeneration, that are applicable to human disease. We have recently described a model of controlled head injury to flies, which remarkably parallels man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a71eabce83b11225de6e617a6d90186
https://doi.org/10.21203/rs.3.pex-949/v1
https://doi.org/10.21203/rs.3.pex-949/v1
Inducing different severities of traumatic brain injury in Drosophila using a piezoelectric actuator
Autor:
Joshua Kim, Nancy M. Bonini, David F. Meaney, Matthew A. Hemphill, Janani Saikumar, China N. Byrns
Publikováno v:
Nat Protoc
Drosophila models have been instrumental in providing insights into molecular mechanisms of neurodegeneration, with wide applications to human disease. The brain degeneration associated with traumatic brain injury (TBI) has been modeled in Drosophila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2684f0e145d4f9a30d5f84a8e371f7dd
https://pubmed.ncbi.nlm.nih.gov/33277631
https://pubmed.ncbi.nlm.nih.gov/33277631
Autor:
Matthew A Hemphill, Borna E Dabiri, Sylvain Gabriele, Lucas Kerscher, Christian Franck, Josue A Goss, Patrick W Alford, Kevin Kit Parker
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22899 (2011)
Over the past decade, investigators have attempted to establish the pathophysiological mechanisms by which non-penetrating injuries damage the brain. Several studies have implicated either membrane poration or ion channel dysfunction pursuant to neur
Externí odkaz:
https://doaj.org/article/6ecee150792e4e0ea2aa32258f766617
Autor:
Stephanie Dauth, Angie M. Greer, Ben M. Maoz, Mary Kate Macedonia, Matthew A. Hemphill, Kevin Kit Parker, Sean P. Sheehy, Tara Murty, Bogdan Budnik
Publikováno v:
Journal of Neurophysiology. 117:1320-1341
Brain in vitro models are critically important to developing our understanding of basic nervous system cellular physiology, potential neurotoxic effects of chemicals, and specific cellular mechanisms of many disease states. In this study, we sought t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3279e8debf523bf953b14cdb4ba31eb
https://doi.org/10.1152/jn.00575.2016
https://doi.org/10.1152/jn.00575.2016
Autor:
Ian Perkins, Patrick H. Campbell, Hongyan Yuan, Blakely B. O'Connor, Kevin Kit Parker, Moran Yadid, Christophe O. Chantre, Feyisayo Eweje, Matthew A. Hemphill, Johan Ulrik Lind, Joost J. Vlassak
Publikováno v:
Lab Chip. 17:3692-3703
Microphysiological systems and organs-on-chips promise to accelerate biomedical and pharmaceutical research by providing accurate in vitro replicas of human tissue. Aside from addressing the physiological accuracy of the model tissues, there is a pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7689fb2a6a4a884ea7acab9915a82bef
https://doi.org/10.1039/c7lc00740j
https://doi.org/10.1039/c7lc00740j
Publikováno v:
Exp Neurol
Although hippocampal damage plays a key role in impairments after concussion, differences in hippocampal information processing during recovery are unknown. Micro-endoscopic calcium imaging was performed before and after primary blast injury in freel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ecfe5d2fdc5cf17ed3bf4010a6f8a1d
https://doi.org/10.1016/j.expneurol.2020.113435
https://doi.org/10.1016/j.expneurol.2020.113435
Autor:
Wesley Pennycooke, Venkata Yelleswarapu, David Issadore, Jina Ko, David Gabrieli, Matthew A. Hemphill, Dave Meaney, Anup Singh, Leon Wu, Gladys G. Lawrence
Publikováno v:
Scientific Reports
A major impediment to improving the treatment of concussion is our current inability to identify patients that will experience persistent problems after the injury. Recently, brain-derived exosomes, which cross the blood-brain barrier and circulate f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e83eea404f50f3fa5a71df118d05f1d
Autor:
J. Nathan Kutz, Pedro D. Maia, Chenfei Zhang, Brendan Zehnder, Kevin Kit Parker, Matthew A. Hemphill
Publikováno v:
Journal of neuroscience methods. 253
Background Focal Axonal Swellings arise in several leading neurodegenerative diseases of the central nervous system and are hallmark features of concussions and traumatic brain injuries. Recent theories mapped how the shape of each swelling affects t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93118c794ca7fe7b4f5bb408905bdad9
https://pubmed.ncbi.nlm.nih.gov/26188255
https://pubmed.ncbi.nlm.nih.gov/26188255