Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Matthew A. Belmonte"'
Autor:
Ardeshir Goliaei, Haley A. Woods, Adriana E. Tron, Matthew A. Belmonte, J. Paul Secrist, Douglas Ferguson, Lisa Drew, Adrian J. Fretland, Bree B. Aldridge, Francis D. Gibbons
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 10, Pp 561-570 (2020)
Anticancer efficacy is driven not only by dose but also by frequency and duration of treatment. We describe a multiscale model combining cell cycle, cellular heterogeneity of B‐cell lymphoma 2 family proteins, and pharmacology of AZD5991, a potent
Externí odkaz:
https://doaj.org/article/07ad18bfe7b84642b234c602cec0a6fa
Autor:
Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell, Alexander W. Hird
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
High expression of Mcl-1 promotes tumorigenesis and resistance to anticancer therapies. Here they report a macrocyclic molecule with high selectivity and affinity for Mcl-1 that exhibits potent anti-tumor effects as single agent and in combination wi
Externí odkaz:
https://doaj.org/article/814ff3ef6b204d84917e2b025f3e1da9
Autor:
Vikram Patel, Melissa Gladstone, Gillian Lancaster, Alok Ranjan, Gauri Divan, Gareth McCray, Emily Jones, Sheffali Gulati, Maria M Crespo-Llado, Mark H Johnson, Emmie Mbale, Debarati Mukherjee, Elin H Williams, Nicholas M Thompson, Supriya Bhavnani, Diksha Gajria, Teresa Del Bianco, Georgia Lockwood-Estrin, Luke Mason, Vukiwe Ngoma, Chisomo Namathanga, Richard Nkhata, Allan Bennie, Ulemu Kawelama, Naina Midha, Anindita Singh, Innocent Mpakiza, Akshat Gautam, Matthew K Belmonte, Sharat Chandran, Bhismadev Chakrabarti
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Introduction Early childhood development forms the foundations for functioning later in life. Thus, accurate monitoring of developmental trajectories is critical. However, such monitoring often relies on time-intensive assessments which necessitate a
Externí odkaz:
https://doaj.org/article/02632097ed674891ae262d3eec3df36c
Autor:
Indu Dubey, Simon Brett, Liliana Ruta, Rahul Bishain, Sharat Chandran, Supriya Bhavnani, Matthew K. Belmonte, Georgia Lockwood Estrin, Mark Johnson, Teodora Gliga, Bhismadev Chakrabarti, on behalf of the START consortium
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Children typically prefer to attend to social stimuli (e.g. faces, smiles) over non-social stimuli (e.g. natural scene, household objects). This preference for social stimuli is believed to be an essential building block for later social skills and h
Externí odkaz:
https://doaj.org/article/f6c3acb032d7439caef818ec838a734f
Autor:
Vahe Bedian, David C. Blakey, Diane M. Simeone, Robert E. Hollingsworth, Christopher Frantz, Meina Liang, Elaine Hurt, David W. Jenkins, Naomi Laing, Jelena Jovanović, Jaspal S. Kang, Lidong Wang, Matthew A. Belmonte, Mark J. Hynes, Jon W. Chesebrough, Sanjoo Jalla, Axel Hernandez, Anne Marie Mazzola, Jerold J. Jordan, Kristen A. McEachern, Youzhen Wang, Neil R. Michaud
Supplementary Materials and Methods; Supplementary Figure S1. Binding kinetics of hedgehog antibodies to human and mouse hedgehog proteins using surface plasmon resonance. Supplementary Figure S2. Hedgehog ligands stimulate mGLI1 reporter activity an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f01c40dab06dfb8ce31bb83ff4b4fb
https://doi.org/10.1158/1535-7163.22501233
https://doi.org/10.1158/1535-7163.22501233
Autor:
Francis D. Gibbons, Haley Woods, Matthew A. Belmonte, Ardeshir Goliaei, Douglas Ferguson, Adriana E. Tron, Bree B. Aldridge, J. Paul Secrist, Adrian J. Fretland, Lisa Drew
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 10, Pp 561-570 (2020)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
Anticancer efficacy is driven not only by dose but also by frequency and duration of treatment. We describe a multiscale model combining cell cycle, cellular heterogeneity of B-cell lymphoma 2 family proteins, and pharmacology of AZD5991, a potent sm
Autor:
Debarati Mukherjee, Supriya Bhavnani, Georgia Lockwood Estrin, Vaisnavi Rao, Jayashree Dasgupta, Hiba Irfan, Bhismadev Chakrabarti, Vikram Patel, Matthew K Belmonte
Publikováno v:
Autism. :136236132211331
Current challenges in early identification of autism spectrum disorder lead to significant delays in starting interventions, thereby compromising outcomes. Digital tools can potentially address this barrier as they are accessible, can measure autism-
Autor:
Dorit Ben-Shalom, Kathryn L. Hotson, Juliet Foster, Suzanne P. Murphy, Zahra Bilal Ahmed, Sofia S. Villar, Claudia Días, Ailbhe McKinney, Matthew K. Belmonte, Emma Weisblatt
Publikováno v:
Autism
Autistic children and adults who are non-verbal/minimally verbal or have an intellectual disability have often been excluded from Autism Spectrum Disorder research. Historical, practical and theoretical reasons for this exclusion continue to deter so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37de7594778683bf256bbc7f187b2c97
https://www.repository.cam.ac.uk/handle/1810/326139
https://www.repository.cam.ac.uk/handle/1810/326139
Autor:
Emma Weisblatt, K. Plaisted Grant, M. Dhariwal, M. S. Fairclough, Matthew K. Belmonte, B. Cook, Caroline Langensiepen, B. Varga-Elmiyeh, Alicia Rybicki, A. E. Malone, S. E. Friend, C. Dias, Prathibha Karanth
Publikováno v:
International Journal of Human–Computer Interaction. 35:643-665
Autism is a heterogenous condition, encompassing many different subtypes and presentations. Of those people with autism who lack communicative speech, some are more skilled at receptive language than their expressive difficulty might suggest. This di
Autor:
Nancy Su, Brian Aquila, Gareth P. Gregory, Stephen Fawell, J. Adam Hendricks, Ammar Adam, Lawrence H. Boise, Jeffrey W. Johannes, Kevin J. Embrey, Edwin Clark, Philip B. Rawlins, Justin Cidado, Francis D. Gibbons, Ricky W. Johnstone, Qing Ye, Elisabetta Chiarparin, Steven L. Kazmirski, Michelle Lamb, J. Paul Secrist, Wenzhan Yang, Alexander Hird, Daniel W. Robbins, Adriana E. Tron, Alwin Schuller, Martin J. Packer, David J. Hargreaves, Xiaolan Zheng, Matthew A. Belmonte, Eric Gangl, Ajay K. Nooka, Shannon M. Matulis, Jason Grant Kettle, Bo Peng, David Matthew Wilson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Mcl-1 is a member of the Bcl-2 family of proteins that promotes cell survival by preventing induction of apoptosis in many cancers. High expression of Mcl-1 causes tumorigenesis and resistance to anticancer therapies highlighting the potential of Mcl