Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Matthew A Schaich"'
Autor:
Brittani L. Schnable, Matthew A. Schaich, Vera Roginskaya, Liam P. Leary, Tyler M. Weaver, Bret D. Freudenthal, Alexander C. Drohat, Bennett Van Houten
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Base excision repair is the main pathway involved in active DNA demethylation. 5-formylcytosine and 5-carboxylcytosine, two oxidized moieties of methylated cytosine, are recognized and removed by thymine DNA glycosylase (TDG) to generate an
Externí odkaz:
https://doaj.org/article/c5ab3255991842278bb091539a39a8ac
Autor:
Sarah R. Hengel, Katherine G. Oppenheimer, Chelsea M. Smith, Matthew A. Schaich, Hayley L. Rein, Julieta Martino, Kristie E. Darrah, Maggie Witham, Oluchi C. Ezekwenna, Kyle R. Burton, Bennett Van Houten, Maria Spies, Kara A. Bernstein
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Templated DNA repair that occurs during homologous recombination and replication stress relies on RAD51. RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs. The Shu complex is a RAD51 paralog-containing complex consisting
Externí odkaz:
https://doaj.org/article/323f61a200624d02a6355a27357eb8cb
Autor:
Matthew A. Schaich, Bennett Van Houten
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
DNA is under constant threat of damage from a variety of chemical and physical insults, such as ultraviolet rays produced by sunlight and reactive oxygen species produced during respiration or inflammation. Because damaged DNA, if not repaired, can l
Externí odkaz:
https://doaj.org/article/272bd76ac4f84daebaf4e6fd2233bedf
Autor:
Matthew A Schaich, Samantha L Sanford, Griffin A Welfer, Samuel A Johnson, Thu H Khoang, Patricia L Opresko, Bret D Freudenthal
Publikováno v:
eLife, Vol 9 (2020)
Telomerase extends telomere sequences at chromosomal ends to protect genomic DNA. During this process it must select the correct nucleotide from a pool of nucleotides with various sugars and base pairing properties, which is critically important for
Externí odkaz:
https://doaj.org/article/4e22fc7309344751ac64f8a5732134ad
Autor:
Sunbok Jang, Sripriya J Raja, Vera Roginskaya, Matthew A Schaich, Simon C Watkins, Bennett Van Houten
Publikováno v:
Nucleic Acids Research.
UV-damaged DNA-binding protein (UV-DDB) is a heterodimeric protein, consisting of DDB1 and DDB2 subunits, that works to recognize DNA lesions induced by UV damage during global genome nucleotide excision repair (GG-NER). Our laboratory previously dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24acc7d2a8371329c2ae93deafa365cb
https://doi.org/10.1093/nar/gkad206
https://doi.org/10.1093/nar/gkad206
Autor:
Zachery Mielko, Yuning Zhang, Harshit Sahay, Yiling Liu, Matthew A. Schaich, Brittani Schnable, Abigail M. Morrison, Debbie Burdinski, Sheera Adar, Miles Pufall, Bennett Van Houten, Raluca Gordân, Ariel Afek
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Somatic mutations are highly enriched at transcription factor (TF) binding sites, with the strongest trend being observed for ultraviolet light (UV)-induced mutations in melanomas. One of the main mechanisms proposed for this hypermutation pattern is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f4aee09ad67b0c92117e66ac6e464c0
https://doi.org/10.1073/pnas.2217422120
https://doi.org/10.1073/pnas.2217422120
Autor:
Matthew A Schaich, Brittani L Schnable, Namrata Kumar, Vera Roginskaya, Rachel C Jakielski, Roman Urban, Zhou Zhong, Neil M Kad, Bennett Van Houten
Publikováno v:
Nucleic Acids Research. 51:e39-e39
Single-molecule characterization of protein–DNA dynamics provides unprecedented mechanistic details about numerous nuclear processes. Here, we describe a new method that rapidly generates single-molecule information with fluorescently tagged protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c613d6db38eb97ed0060c50810065b7
https://doi.org/10.1093/nar/gkad095
https://doi.org/10.1093/nar/gkad095
Publikováno v:
Biophysical Journal. 122:355a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe4e55cca9e3608cedbf18e2b553682c
https://doi.org/10.1016/j.bpj.2022.11.1967
https://doi.org/10.1016/j.bpj.2022.11.1967
Autor:
Bennett Van Houten, Sheila S. David, Chandrima Majumdar, Cindy Khuu, Matthew A. Schaich, Brittani L Schnable, Sunbok Jang, Simon C. Watkins
Publikováno v:
Nucleic acids research, vol 49, iss 14
Nucleic Acids Research
Nucleic Acids Research
The oxidative base damage, 8-oxo-7,8-dihydroguanine (8-oxoG) is a highly mutagenic lesion because replicative DNA polymerases insert adenine (A) opposite 8-oxoG. In mammalian cells, the removal of A incorporated across from 8-oxoG is mediated by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdce6734987315aa70b2f26bec2dbeaa
https://escholarship.org/uc/item/7bs54080
https://escholarship.org/uc/item/7bs54080
Autor:
Schnable, Brittani L., Schaich, Matthew A., Roginskaya, Vera, Leary, Liam P., Weaver, Tyler M., Freudenthal, Bret D., Drohat, Alexander C., Van Houten, Bennett
Publikováno v:
Nature Communications; 10/25/2024, Vol. 15 Issue 1, p1-11, 11p