Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Matthew A Farren"'
Autor:
Michael Brandon Ware, Maggie Phillips, Christopher McQuinn, Mohammad Y. Zaidi, Hannah M. Knochelmann, Emily Greene, Brian Robinson, Cameron J. Herting, Thomas A. Mace, Zhengjia Chen, Chao Zhang, Matthew R. Farren, Amanda N. Ruggieri, Jacob S. Bowers, Reena Shakya, Alton B. Farris, Gregory Young, William E. Carson III, Bassel El-Rayes, Chrystal M. Paulos, Gregory B. Lesinski
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
This study aimed to enhance antitumor immune responses to pancreatic cancer via Ab-based blockade of IL-6 and cytotoxic T-lymphocyte–associated protein 4 (CTLA-4). Mice bearing s.c. or orthotopic pancreatic tumors were treated with blocking Abs to
Externí odkaz:
https://doaj.org/article/c9e661e36d174f30b84405ca8e2d56e4
Autor:
Erin E. Talbert, Heather L. Lewis, Matthew R. Farren, Mitchell L. Ramsey, Jeffery M. Chakedis, Priyani Rajasekera, Ericka Haverick, Angela Sarna, Mark Bloomston, Timothy M. Pawlik, Teresa A. Zimmers, Gregory B. Lesinski, Phil A. Hart, Mary E. Dillhoff, Carl R. Schmidt, Denis C. Guttridge
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 2, Pp 358-368 (2018)
Abstract Background Cancer‐associated wasting, termed cancer cachexia, has a profound effect on the morbidity and mortality of cancer patients but remains difficult to recognize and diagnose. While increases in circulating levels of a number of inf
Externí odkaz:
https://doaj.org/article/320df16659484be68f873257a408f01b
Autor:
Gregory B. Lesinski, Bassel F. El-Rayes, Shishir K. Maithel, Rafi Ahmed, Juan M. Sarmiento, Zhengjia Chen, Chao Zhang, Ganji Purnachandra Nagaraju, Matthew R. Farren, Hannah Komar, Brian M. Olson, Amanda N. Ruggieri, Mohammad Y. Zaidi, Michael B. Ware, Yuchen Zhang
Supplemental Figures S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334b97489ab6bc6ce4b453fc89989db7
https://doi.org/10.1158/1535-7163.22521040
https://doi.org/10.1158/1535-7163.22521040
Autor:
Gregory B. Lesinski, Christin E. Burd, Trinayan Kashyap, Boris Klebanov, Marsha Crochiere, Sivan Elloul, Yosef Landesman, Kari Kendra, Gregory Young, Omar Elnaggar, Reena Shakya, Rebecca C. Hennessey, Matthew R. Farren
Selinexor, a selective inhibitor of nuclear export (SINE) compound targeting exportin-1, has previously been shown to inhibit melanoma cell growth in vivo. We hypothesized that combining selinexor with antibodies that block or disrupt T-cell checkpoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e518810db0529b9a40a9c84db1b373
https://doi.org/10.1158/1535-7163.c.6539550
https://doi.org/10.1158/1535-7163.c.6539550
Autor:
Gregory B. Lesinski, Christin E. Burd, Trinayan Kashyap, Boris Klebanov, Marsha Crochiere, Sivan Elloul, Yosef Landesman, Kari Kendra, Gregory Young, Omar Elnaggar, Reena Shakya, Rebecca C. Hennessey, Matthew R. Farren
Supplemental Figure S1: Effects of alternative dosing schedules for selinexor (15 mg/kg) and anti-PD-1 on systemic immune populations; Supplemental Figure S2: Effects of alternative dosing schedules for selinexor (10 mg/kg) and anti-PD-1 on systemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62759dda4e94d4aa77a8456db24faaf
https://doi.org/10.1158/1535-7163.22510242
https://doi.org/10.1158/1535-7163.22510242
Autor:
Gregory B. Lesinski, Denis C. Guttridge, Tanios Bekaii-Saab, Mark Bloomston, Jennifer M. Maskarinec, Priyani Rajasekera, Cynthia D. Timmers, Zheng Che, Omar Elnaggar, Gregory S. Young, Alton B. Farris, Matthew R. Farren, Thomas A. Mace, Jennifer Yang, Erin E. Talbert
Supplementary Material contains Supplementary Figures 1-5 and Supplementary Table 1. Supplementary Figure 1. MEK162 treatment prevents cancer-induced weight loss and muscle wasting. Supplementary Figure 2. Development of a MEK162 resistant C-26 tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f58f079406240b5229b3033b34a7a14
https://doi.org/10.1158/1535-7163.22503772
https://doi.org/10.1158/1535-7163.22503772
Autor:
Gregory B. Lesinski, Bassel F. El-Rayes, Shishir K. Maithel, Rafi Ahmed, Juan M. Sarmiento, Zhengjia Chen, Chao Zhang, Ganji Purnachandra Nagaraju, Matthew R. Farren, Hannah Komar, Brian M. Olson, Amanda N. Ruggieri, Mohammad Y. Zaidi, Michael B. Ware, Yuchen Zhang
Pancreatic ductal adenocarcinoma (PDAC) has a prominent fibrotic stroma, which is a result of interactions between tumor, immune and pancreatic stellate cells (PSC), or cancer-associated fibroblasts (CAF). Targeting inflammatory pathways present with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230926bfbd23653fd8c0df4dc849af8a
https://doi.org/10.1158/1535-7163.c.6542881
https://doi.org/10.1158/1535-7163.c.6542881
Autor:
Gregory B. Lesinski, Tanios Bekaii-Saab, Miguel Villalona-Calero, Anne M. Noonan, Daniel Ahn, Sanaa Tahiri, Kristen Ciombor, Christina Wu, Sameh Mikhail, Susan Geyer, Thomas A. Mace, Matthew R. Farren
supplemental legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541ea24e0e66538aa04451521f16f756
https://doi.org/10.1158/1078-0432.22458234
https://doi.org/10.1158/1078-0432.22458234
Autor:
Gregory B. Lesinski, Tanios Bekaii-Saab, Miguel Villalona-Calero, Anne M. Noonan, Daniel Ahn, Sanaa Tahiri, Kristen Ciombor, Christina Wu, Sameh Mikhail, Susan Geyer, Thomas A. Mace, Matthew R. Farren
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a 5-year survival rate Experimental Design: Peripheral blood was collected from 73 patients presenting with previously untreated metastatic PDAC. Extensive immunologic prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4bc9804b0eab79b0267b82851a905c
https://doi.org/10.1158/1078-0432.c.6523881
https://doi.org/10.1158/1078-0432.c.6523881
Autor:
Zobeida Cruz-Monserrate, Craig D. Logsdon, Ralph B. Arlinghaus, Xiaohong Leng, Huamin Wang, Deyali Chatterjee, Todd Moore, Liran Zhou, Rosa F. Hwang, Defeng Deng, Yan Liu, Carl Schmidt, Thomas A. Mace, Matthew R. Farren, Tanios Bekaii-Saab, Gregory B. Lesinski, Myrriah Chavez-Tomar, Niharika Badi, Agnieszka Katarzyna Swidnicka-Siergiejko, Sobeyda B. Gomez-Chou
Supplementary Table 1. List of antibodies used for immunohistochemical staining of mouse pancreas.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27260b0aa4131c9077d6834aa54bc5fd
https://doi.org/10.1158/0008-5472.22413510
https://doi.org/10.1158/0008-5472.22413510