Zobrazeno 1 - 10
of 370
pro vyhledávání: '"Matthew A Ciorba"'
Autor:
Nancy D. Marin, Michelle Becker-Hapak, Wilbur M. Song, Quazim A. Alayo, Lynne Marsala, Naomi Sonnek, Melissa M. Berrien-Elliott, Mark Foster, Jennifer A. Foltz, Jennifer Tran, Pamela Wong, Celia C. Cubitt, Patrick Pence, Kimberly Hwang, Alice Y. Zhou, Miriam T. Jacobs, Timothy Schappe, David A. Russler-Germain, Ryan C. Fields, Matthew A. Ciorba, Todd A. Fehniger
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTMetastatic (m) colorectal cancer (CRC) is an incurable disease with a poor prognosis and thus remains an unmet clinical need. Immune checkpoint blockade (ICB)-based immunotherapy is effective for mismatch repair-deficient (dMMR)/microsatellit
Externí odkaz:
https://doaj.org/article/989a296ad9bc48bf902f4f5ef1d3f555
Autor:
Lori R. Holtz, B. Darren Nix, Sewuese E. Akuse, Carla Hall-Moore, Rodney D. Newberry, Matthew A. Ciorba, Parakkal Deepak, Maria Zulfiqar, Jeng-Jong Shieh, James R. Johnson, I. Rochelle Riley, Richard B. Dorshow
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 4, Pp 491-497 (2024)
Background and Aims: The dual sugar absorption test as a classic measure of human intestinal permeability has limited clinical utility due to lengthy and cumbersome urine collection, assay variability, and long turnaround. We aimed to determine if th
Externí odkaz:
https://doaj.org/article/032a99dca9c1478a80c46ccf9302f4f5
Autor:
Qiru Zeng, Avan Antia, Luis Alberto Casorla-Perez, Maritza Puray-Chavez, Sebla B. Kutluay, Matthew A. Ciorba, Siyuan Ding
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, much effort has been dedicated to identifying effective antivirals against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A number of calpain inhibitors
Externí odkaz:
https://doaj.org/article/ea4945db2bf6456cb0f9f479f9a0b715
Autor:
Avan Antia, David M. Alvarado, Qiru Zeng, Luis A. Casorla-Perez, Deanna L. Davis, Naomi M. Sonnek, Matthew A. Ciorba, Siyuan Ding
Publikováno v:
Viruses, Vol 16, Iss 4, p 634 (2024)
The Omicron variant of SARS-CoV-2, characterized by multiple subvariants including BA.1, XBB.1.5, EG.5, and JN.1, became the predominant strain in early 2022. Studies indicate that Omicron replicates less efficiently in lung tissue compared to the an
Externí odkaz:
https://doaj.org/article/38974c74f9894c49aa5e9ae3369a7b50
Autor:
Saeed Soleymanjahi, Valerie Blanc, Elizabeth A. Molitor, David M. Alvarado, Yan Xie, Vered Gazit, Jeffrey W. Brown, Kathleen Byrnes, Ta-Chiang Liu, Jason C. Mills, Matthew A. Ciorba, Deborah C. Rubin, Nicholas O. Davidson
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
RNA-binding protein 47 (RBM47) is required for embryonic endoderm development, but a role in adult intestine is unknown. We studied intestine-specific Rbm47-knockout mice (Rbm47-IKO) following intestinal injury and made crosses into ApcMin/+ mice to
Externí odkaz:
https://doaj.org/article/edc9e8e3efab4366b48b55f69d04abad
Autor:
Ankur P. Patel, Troy K. Sanders, Preeti Prakash, Jade Law, Sujay Alvencar, Alyssa Choi, Janaki Shah, Karishma Patel, Padmavathi Srivoleti, Kirtan Chauhan, Simcha Weissman, Erik Holzwanger, Rohit Dhingra, Michelle Nguyen, Daniel Kim, Tahnee Sidhu, Christopher Stallwood, Aaron Dickstein, Nimisha Parekh, Osama Altayar, Matthew A. Ciorba, Jessica Yu, Lea Ann Chen, James H. Tabibian, Berkeley N. Limketkai
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 6, Pp 909-915 (2022)
Background and Aims: Gastrointestinal (GI) symptoms occur among patients diagnosed with coronavirus disease 2019 (COVID-19), and there is clear evidence that SARS-CoV-2, the causative pathogen, infects the GI tract. In this large, multicenter cohort
Externí odkaz:
https://doaj.org/article/5bb30ffe95684f579ded1f3778c93500
Autor:
Sunaina Rengarajan, Emily E. Vivio, Miles Parkes, Daniel A. Peterson, Elisha D.O. Roberson, Rodney D. Newberry, Matthew A. Ciorba, Chyi-Song Hsieh
Publikováno v:
Gut Microbes, Vol 11, Iss 3, Pp 405-420 (2020)
Aberrant immune responses against gut microbiota are thought to be key drivers of inflammatory bowel disease (IBD) pathogenesis. However, the extent and targets of immunoglobulin (Ig) A versus IgG responses to gut bacteria in IBD and its association
Externí odkaz:
https://doaj.org/article/027472a3caa74ac5be4ba2b85f9a1b95
Autor:
William F. Stenson, Matthew A. Ciorba
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
TLRs, key components of the innate immune system, recognize microbial molecules. However, TLRs also recognize some nonmicrobial molecules. In particular, TLR2 and TLR4 recognize hyaluronic acid, a glycosaminoglycan in the extracellular matrix. In neo
Externí odkaz:
https://doaj.org/article/ec7806572a784628b44c15d80186f6e3
Autor:
Vered A. Gazit, Elzbieta A. Swietlicki, Miranda U. Liang, Adam Surti, Raechel McDaniel, Mackenzie Geisman, David M. Alvarado, Matthew A. Ciorba, Grant Bochicchio, Obeid Ilahi, John Kirby, William J. Symons, Nicholas O. Davidson, Marc S. Levin, Deborah C. Rubin
Publikováno v:
JCI Insight, Vol 5, Iss 23 (2020)
Loss of functional small bowel surface area following surgical resection for disorders such as Crohn’s disease, intestinal ischemic injury, radiation enteritis, and in children, necrotizing enterocolitis, atresia, and gastroschisis, may result in s
Externí odkaz:
https://doaj.org/article/4d56b0697f5f486581ccd9d4682288aa
Autor:
Sunaina Rengarajan, Kathryn A. Knoop, Arvind Rengarajan, Jiani N. Chai, Jose G. Grajales-Reyes, Vijay K. Samineni, Emilie V. Russler-Germain, Prabha Ranganathan, Alessio Fasano, Gregory S. Sayuk, Robert W. Gereau, IV, Andrew L. Kau, Dan Knights, Purna C. Kashyap, Matthew A. Ciorba, Rodney D. Newberry, Chyi-Song Hsieh
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 7, Pp 100124- (2020)
Summary: Stress is a known trigger for flares of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS); however, this process is not well understood. Here, we find that restraint stress in mice leads to signs of diarrhea, fecal dysbiosi
Externí odkaz:
https://doaj.org/article/332b58370fdc4d669d7cafa06882bcf2