Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Matthew A Burchill"'
Autor:
Alyssa R. Goldberg, Megan Ferguson, Sarit Pal, Rachel Cohen, David J. Orlicky, Rebecca L. McCullough, Joseph M. Rutkowski, Matthew A. Burchill, Beth A. Jirón Tamburini
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The lymphatic vasculature of the liver is vital for liver function as it maintains fluid and protein homeostasis and is important for immune cell transport to the lymph node. Chronic liver disease is associated with increased expression of inflammato
Externí odkaz:
https://doaj.org/article/f8529ddf76e94ee19fd406204ab0f4c5
Autor:
Isak W. Tengesdal, Alberto Dinarello, Nicholas E. Powers, Matthew A. Burchill, Leo A. B. Joosten, Carlo Marchetti, Charles A. Dinarello
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Tumors evade the immune system by inducing inflammation. In melanoma, tumor-derived IL-1β drives inflammation and the expansion of highly immunosuppressive myeloid-derived suppressor cells (MDSCs). Similar in many tumors, melanoma is also linked to
Externí odkaz:
https://doaj.org/article/9a1a4bb25a974f229a6cb26c4d893671
Autor:
Matthew A Burchill, Matthew P Salomon, Lucy Golden-Mason, Amanda Wieland, Ana C Maretti-Mira, Michael Gale, Hugo R Rosen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009799 (2021)
Chronic infection with HCV is manifested by dysregulation of innate immune responses and impaired T cell function at multiple levels. These changes may impact susceptibility to other infections, responsiveness to antiviral therapies, vaccine responsi
Externí odkaz:
https://doaj.org/article/4b3c7cb12eb447ffbe8a00b8895b480b
Autor:
Eric T Clambey, Jacob Gadwa, Thomas E Bickett, Laurel B Darragh, Shilpa Bhatia, Miles Piper, Benjamin Van Court, Shiv Bhuvane, Diemmy Nguyen, Varuna Nangia, Sana D Karam, Michael W Knitz, Ayman J Oweida, Adam C Mueller, Douglas G Osborne, Xiyuan Bai, Sarah E Ferrara, Mary-Keara Boss, Andrew Goodspeed, Matthew A Burchill, Beth A Jirón Tamburini, Edward D Chan, Curtis R Pickering
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Background Numerous trials combining radiation therapy (RT) and immunotherapy in head and neck squamous cell carcinoma (HNSCC) are failing. Using preclinical immune cold models of HNSCC resistant to RT-immune checkpoint inhibitors, we investigate the
Externí odkaz:
https://doaj.org/article/cbf79a9cbfcd4744b19d4b8a1b088264
Autor:
Shannon M Walsh, Ryan M Sheridan, Erin D Lucas, Thu A Doan, Brian C Ware, Johnathon Schafer, Rui Fu, Matthew A Burchill, Jay R Hesselberth, Beth Ann Jiron Tamburini
Publikováno v:
eLife, Vol 10 (2021)
The detection of foreign antigens in vivo has relied on fluorescent conjugation or indirect read-outs such as antigen presentation. In our studies, we found that these widely used techniques had several technical limitations that have precluded a com
Externí odkaz:
https://doaj.org/article/e1a779a5cbfd4b2eb30dfea75847fa35
Autor:
Kathryn D. Tuttle, Katherine A. Waugh, Paula Araya, Ross Minter, David J. Orlicky, Michael Ludwig, Zdenek Andrysik, Matthew A. Burchill, Beth A.J. Tamburini, Colin Sempeck, Keith Smith, Ross Granrath, Dayna Tracy, Jessica Baxter, Joaquin M. Espinosa, Kelly D. Sullivan
Publikováno v:
Cell Reports, Vol 33, Iss 7, Pp 108407- (2020)
Summary: Individuals with Down syndrome (DS; trisomy 21) display hyperactivation of interferon (IFN) signaling and chronic inflammation, which could potentially be explained by the extra copy of four IFN receptor (IFNR) genes encoded on chromosome 21
Externí odkaz:
https://doaj.org/article/8fd7536ebdba4b9c98e33eeca1e00d4f
Publikováno v:
Frontiers in Physiology, Vol 10 (2020)
Chronic liver disease (CLD) is a global health epidemic causing ∼2 million deaths annually worldwide. As the incidence of CLD is expected to rise over the next decade, understanding the cellular and molecular mediators of CLD is critical for develo
Externí odkaz:
https://doaj.org/article/7fac8e53a534473cb2ce56de11424bc2
Autor:
Beth A. Jiron Tamburini, Jeffrey M. Finlon, Austin E. Gillen, Michael S. Kriss, Kent A. Riemondy, Rui Fu, Ronald P. Schuyler, Jay R. Hesselberth, Hugo R. Rosen, Matthew A. Burchill
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Liver lymphatic vessels support liver function by draining interstitial fluid, cholesterol, fat, and immune cells for surveillance in the liver draining lymph node. Chronic liver disease is associated with increased inflammation and immune cell infil
Externí odkaz:
https://doaj.org/article/d29ecb98b02b49bc805850487ed15d2d
Autor:
Jason T. White, Eric W. Cross, Matthew A. Burchill, Thomas Danhorn, Martin D. McCarter, Hugo R. Rosen, Brian O’Connor, Ross M. Kedl
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Virtual memory T cells are CD8 T cells with memory phenotype present in unimmunized mice. Here the authors show that these cells have higher affinity for self-antigen, depend on IL-15 for proliferation and antigen-non-specific cytotoxicity in mice, a
Externí odkaz:
https://doaj.org/article/5b504adf9a774808aa2014fe7ae6ebee
Autor:
Matthew A Burchill, Justin A Roby, Nanette Crochet, Megan Wind-Rotolo, Amy E Stone, Michael G Edwards, Rachael J Dran, Michael S Kriss, Michael Gale, Hugo R Rosen
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186213 (2017)
ResultsFirst, in patients receiving two different combinations of DAAs, we found that DAAs induced not only rapid viral clearance, but also a re-setting of antiviral immune responses in the peripheral blood. Specifically, we see a rapid decline in th
Externí odkaz:
https://doaj.org/article/66720068face4cb0ad7a33940e4a2f9e