Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Matthew A, Quinn"'
Autor:
Jeremy C. Pamplin, MD, FCCM, FACP, Brooke Gray, DO, Matthew T. Quinn, Jeanette R. Little, MS, Christopher J. Colombo, MD, MA, FACP, FCCM, Sanjay Subramanian, MD, MMM, Joseph C. Farmer, MD, MCCM, Michael Ries, MD, MBA, FCCM, FCCP, FACP, Benjamin Scott, MD, Donna Lee Armaignac
Publikováno v:
Critical Care Explorations, Vol 6, Iss 5, p e1091 (2024)
The COVID-19 pandemic caused tremendous disruption to the U.S. healthcare system and nearly crippled some hospitals during large patient surges. Limited ICU beds across the country further exacerbated these challenges. Telemedicine, specifically tele
Externí odkaz:
https://doaj.org/article/f15d73c18336413bae971a265636be54
Autor:
Rabina Mainali, Nancy Buechler, Cristian Otero, Laken Edwards, Chia-Chi Key, Cristina Furdui, Matthew A Quinn
Publikováno v:
eLife, Vol 12 (2024)
One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effe
Externí odkaz:
https://doaj.org/article/dd51243f29f342b8ab5b57e0c54859d0
Autor:
Allison K. Meyers, Zhan Wang, Wenzheng Han, Qingxia Zhao, Manal Zabalawi, Likun Duan, Juan Liu, Qianyi Zhang, Rajesh K. Manne, Felipe Lorenzo, Matthew A. Quinn, Qianqian Song, Daping Fan, Hui-Kuan Lin, Cristina M. Furdui, Jason W. Locasale, Charles E. McCall, Xuewei Zhu
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111941- (2023)
Summary: Activating the macrophage NLRP3 inflammasome can promote excessive inflammation with severe cell and tissue damage and organ dysfunction. Here, we show that pharmacological or genetic inhibition of pyruvate dehydrogenase kinase (PDHK) signif
Externí odkaz:
https://doaj.org/article/9e44575ee34a4202a7a3e462e4561170
Autor:
Tae Seok Oh, Manal Zabalawi, Shalini Jain, David Long, Peter W. Stacpoole, Charles E. McCall, Matthew A. Quinn
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to an infection. The metabolic aberrations associated with sepsis underly an acute and organism-wide hyperinflammatory response and multiple organ dysfunction; howeve
Externí odkaz:
https://doaj.org/article/5d981fcaf4444ba598df155e5fb19c2a
Autor:
Chia-Chi C. Key, Andrew C. Bishop, Xianfeng Wang, Qingxia Zhao, Guan-yuan Chen, Matthew A. Quinn, Xuewei Zhu, Qibin Zhang, John S. Parks
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 7, Pp 1075-1086 (2020)
The glycerol phosphate pathway produces more than 90% of the liver triacylglycerol (TAG). LysoPA, an intermediate in this pathway, is produced by glycerol-3-phosphate acyltransferase. Glycerophosphodiester phosphodiesterase domain containing 3 (GDPD3
Externí odkaz:
https://doaj.org/article/ada947bef86b44a49c6c3c0a64e2b37e
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
A Krebs cycle intermediate metabolite, itaconate, has gained attention as a potential antimicrobial and autoimmune disease treatment due to its anti-inflammatory effects. While itaconate and its derivatives pose an attractive therapeutic option for t
Externí odkaz:
https://doaj.org/article/1791641852a64c1e8ad7bde9e41bc54b
Autor:
Rabina Mainali, Manal Zabalawi, David Long, Nancy Buechler, Ellen Quillen, Chia-Chi Key, Xuewei Zhu, John S Parks, Cristina Furdui, Peter W Stacpoole, Jennifer Martinez, Charles E McCall, Matthew A Quinn
Publikováno v:
eLife, Vol 10 (2021)
Metabolic reprogramming between resistance and tolerance occurs within the immune system in response to sepsis. While metabolic tissues such as the liver are subjected to damage during sepsis, how their metabolic and energy reprogramming ensures surv
Externí odkaz:
https://doaj.org/article/54dd853ae26241009d6cb06d0d6d3a95
Autor:
Zhan Wang, Qingxia Zhao, Yan Nie, Yi Yu, Biswapriya B. Misra, Manal Zabalawi, Jeff W. Chou, Chia-Chi C. Key, Anthony J. Molina, Matthew A. Quinn, Michael B. Fessler, John S. Parks, Charles E. McCall, Xuewei Zhu
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Increased flux of glucose through glycolysis is a hallmark of inflammatory macrophages and is essential for optimal effector functions. Solute carrier (SLC) 37A2 is an endoplasmic reticulum-anchored phosphate-linked glucose-6-phosphate trans
Externí odkaz:
https://doaj.org/article/5cfa8e8902044865933594eb473988ea
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2690-2701 (2018)
Summary: Glucocorticoids (GCs) are master regulators of systemic metabolism. Intriguingly, Cushing’s syndrome, a disorder of excessive GCs, phenocopies several menopause-induced metabolic pathologies. Here, we show that the glucocorticoid receptor
Externí odkaz:
https://doaj.org/article/9f309502649b4a3582b0b39f141656c5
Autor:
Anastasiya Vinokurtseva, Matthew P. Quinn, Mandy Wai, Victoria Leung, Monali Malvankar-Mehta, Cindy M.L. Hutnik
Publikováno v:
Ophthalmology Glaucoma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00aa468c4ed59fbe1f041af9a61c9f90
https://doi.org/10.1016/j.ogla.2023.04.007
https://doi.org/10.1016/j.ogla.2023.04.007