Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Matthew J. Wyvratt"'
Autor:
Catherine Abbadie, Raul F. Alvaro, Lin-Lin Shiao, Mark Rosenbach, Lisa F. Frey, Marc D. Chioda, Ravi P. Nargund, Richard Hajdu, Kathleen Sullivan, Robert J. DeVita, Joseph F. Leone, Kevin M. Belyk, Jenna L. Terebetski, Amanda K. Makarewicz, Elliot J. Martel, Gino Salituro, Bindhu V. Karanam, Raman K. Bakshi, James Dellureficio, Selena Fung, Ping Liu, Linda Chang, Nina Jochnowitz, Shruti Mistry, Joyce Shuman, Linus S. Lin, Yan Guo, Maria Madeira, Shane W. Krska, Mark McLaughlin, Erin McGowan, Harry R. Chobanian, Jessica Alexander, Matthew J. Wyvratt, Qingmei Hong, Thomas J. Lanza
Publikováno v:
ACS Medicinal Chemistry Letters. 5:717-721
We report herein the identification of MK-4409, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. Starting from a high throughput screening (HTS) hit, medicinal chemistry efforts focused on optimizing of FAAH inhibition in vitro pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbc5aefed73bfbd91d72c5b2ca7e347
https://doi.org/10.1021/ml5001239
https://doi.org/10.1021/ml5001239
Autor:
Palucki Brenda, Patrick G. Pollard, Liangqin Guo, Tung M. Fong, Matthew J. Wyvratt, Randy R. Miller, Shuwen He, Constantin Tamvakopoulos, Iyassu K. Sebhat, Qianping Peng, Ravi P. Nargund, Zhixiong Ye, Airu S. Chen, Doreen E. Cashen, David H. Weinberg, Min K. Park, Raman K. Bakshi, D. Euan MacIntyre, Howard Y. Chen, Rui Tang, Tanya MacNeil, Qingmei Hong, Alison M. Strack, Ralph A. Stearns, Jian Liu, William J. Martin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2330-2334
We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99aea0aa624d82cc9bc8f3cfa4bdb369
https://doi.org/10.1016/j.bmcl.2011.02.090
https://doi.org/10.1016/j.bmcl.2011.02.090
Autor:
Yingjie Lai, Ralph A. Stearns, Qianping Peng, Ravi P. Nargund, Qingmei Hong, Jian Liu, Rui Tang, Matthew J. Wyvratt, Raman K. Bakshi, Randy R. Miller, Tianying Jian, Alison M. Strack, Tanya MacNeil, Liangqin Guo, Howard Y. Chen, James Dellureficio, Iyassu K. Sebhat, Peter H. Dobbelaar, Airu S. Chen, Constantin Tamvakopoulos, David H. Weinberg, Tung M. Fong, Christopher L. Franklin, Shuwen He, Zhixiong Ye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4399-4405
We report a series of potent and selective MC4R agonists based on spiroindane amide privileged structures for potential treatments of obesity. Among the synthetic methods used, Method C allows rapid synthesis of the analogs. The series of compounds c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04db1e6e6855a321002bb787613d21e
https://doi.org/10.1016/j.bmcl.2010.06.062
https://doi.org/10.1016/j.bmcl.2010.06.062
Autor:
Howard Y. Chen, William J. Martin, D. Euan MacIntyre, Zhixiong Ye, Raman K. Bakshi, Alison M. Strack, Doreen E. Cashen, Jian Liu, Yingjie Lai, Tianying Jian, Constantin Tamvakopoulos, Nancy N. Tsou, Shuwen He, James Dellureficio, Tung M. Fong, Peter H. Dobbelaar, David H. Weinberg, Airu S. Chen, Qingmei Hong, Iyassu K. Sebhat, Tanya MacNeil, Christopher L. Franklin, Ravi P. Nargund, Ralph A. Stearns, Rui Tang, Richard G. Ball, Matthew J. Wyvratt, Randy R. Miller, Liangqin Guo, Qianping Peng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2106-2110
We report the design, synthesis and properties of spiroindane based compound 1, a potent, selective, orally bioavailable, non-peptide melanocortin subtype-4 receptor agonist. Compound 1 shows excellent erectogenic activity in the rodent models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecb491322cadefd63c62faedffb60b8
https://doi.org/10.1016/j.bmcl.2010.02.058
https://doi.org/10.1016/j.bmcl.2010.02.058
Autor:
Marc L. Reitman, Cheng Guo, Theresa M. Kelly, Constantin Tamvakopoulos, Joseph M. Metzger, Tianying Jian, Howard Y. Chen, Arthur A. Patchett, Oksana C. Palyha, Alison M. Strack, Allan J. Goodman, Ravi P. Nargund, Peter H. Dobbelaar, Yanqing Kan, Mark Hadden, Larry Yet, Peter R. Guzzo, Qianping Peng, Linus S. Lin, Shuwen He, Lauren P. Shearman, Alan J. Henderson, Carina P. Tan, Sargent Bruce J, Xiao-Ming Guan, Scott D. Feighner, Iyassu K. Sebhat, Jie Pan, Jian Liu, Donald J. Marsh, Matthew J. Wyvratt, Andrew D. Howard, Megan Ruenz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1913-1917
We report SAR studies on a novel non-peptidic bombesin receptor subtype-3 (BRS-3) agonist lead series derived from high-throughput screening hit RY-337. This effort led to the discovery of compound 22e with significantly improved potency at both rode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9388422b542c24893358d41aa77156
https://doi.org/10.1016/j.bmcl.2010.01.154
https://doi.org/10.1016/j.bmcl.2010.01.154
Autor:
Dan A. Ostlind, Marlene D. Drag, Matthew J. Wyvratt, Pierre deMontigny, David W. Fink, Steven L. Colletti, Wesley L. Shoop, Michelle B. Ayer, Chunshi Li, Steve Salva, Michelle Zakson, Lynn M. Warmke, Peter T. Meinke, Thomas L. Shih, Dong Ok, Michael H. Fisher, B.F. Michael, Dennis M. Schmatz, Julie Lim
Publikováno v:
Journal of Medicinal Chemistry. 52:3505-3515
Nodulisporic acid A (1) is a structurally complex fungal metabolite that exhibits systemic efficacy against fleas via modulation of an invertebrate specific glutamate-gated ion channel. In order to identify a nodulisporamide suitable for monthly oral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8913b9a62f0260352bc8493870104e
https://doi.org/10.1021/jm801334v
https://doi.org/10.1021/jm801334v
Autor:
Tesfaye Biftu, Dennis M. Schmatz, Penny Sue Leavitt, Paul A. Liberator, Matthew J. Wyvratt, Anne Gurnett, John Mathew, Michael H. Fisher, Donald Thompson, Gilles Ouvry, Andrew Scribner, Chris Brown, Joseph A. Moore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1517-1521
Novel 2,3-diarylindoles bearing an amine substituent at the indole 5- and 6-positions have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89d716eae661d5308a05e327f2850b7
https://doi.org/10.1016/j.bmcl.2009.01.001
https://doi.org/10.1016/j.bmcl.2009.01.001
Autor:
Susan Meitz, John Mathew, Penny Sue Leavitt, Anne Gurnett, Donald Thompson, Paul A. Liberator, Michael H. Fisher, Tesfaye Biftu, Dennis M. Schmatz, Andrew Scribner, Matthew J. Wyvratt, Chris Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5263-5267
Novel 5,6-diarylimidazo[2,1-b][1,3]thiazoles bearing an amine substituent at the imidazothiazole 2-position have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f97a9f9374860ab441b140794bd85f
https://doi.org/10.1016/j.bmcl.2008.08.063
https://doi.org/10.1016/j.bmcl.2008.08.063
Autor:
Heather L. Sings, Mark T. Goulet, Matthew J. Wyvratt, Iyassu K. Sebhat, Liangqin Guo, Rui Tang, Ravi P. Nargund, Qianping Peng, Euan Macintyre, Feroze Ujjainwalla, Constantin Tamvakopoulos, Zhixiong Ye, Lex H.T. Van der Ploeg, David H. Weinberg, Tanya MacNeil, John Huber
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3242-3247
Discovery of a series of tert-butyl pyrrolidine derived, potent and orally bioavailable melanocortin receptor subtype-4 (MC4R) selective modulators is disclosed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df57b635925179aebc3ae868f442a4cc
https://doi.org/10.1016/j.bmcl.2008.04.049
https://doi.org/10.1016/j.bmcl.2008.04.049
Autor:
Matthew J. Wyvratt, Vivien A. Warren, John P. Felix, Maria L. Garcia, Scott B. Hoyt, William H. Parsons, Kathryn A. Lyons, Xiaohua Li, Michael H. Fisher, Clare London, McHardy M. Smith, Birgit T. Priest, Gregory J. Kaczorowski, Doreen E. Cashen, William J. Martin, D. Euan MacIntyre, Brande S. Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1963-1966
A series of 3-amino-1,5-benzodiazepinones were synthesized and evaluated as potential sodium channel blockers in a functional, membrane potential-based assay. One member of this series displayed subnanomolar, state-dependent sodium channel block, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b3b0b1ace18d4deb975e9213b0b5f2
https://doi.org/10.1016/j.bmcl.2008.01.123
https://doi.org/10.1016/j.bmcl.2008.01.123