Zobrazeno 1 - 10
of 390
pro vyhledávání: '"Matthew D. Smith"'
Autor:
Larissa Jank, Ajay Kesharwani, Taekyung Ryu, Deepika Joshi, Dimitrios C. Ladakis, Matthew D. Smith, Saumitra Singh, Tanina Arab, Kenneth W. Witwer, Peter A. Calabresi, Chan-Hyun Na, Pavan Bhargava
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Extracellular vesicles (EVs) are released by all cells, can cross the blood–brain barrier, and have been shown to play an important role in cellular communication, substance shuttling, and immune modulation. In recent years EVs have shifte
Externí odkaz:
https://doaj.org/article/58832157349e4b658d1e863b8fc976b1
Autor:
Sachin P Gadani, Saumitra Singh, Sophia Kim, Jingwen Hu, Matthew D Smith, Peter A Calabresi, Pavan Bhargava
Publikováno v:
eLife, Vol 12 (2024)
While modern high efficacy disease modifying therapies have revolutionized the treatment of relapsing-remitting multiple sclerosis, they are less effective at controlling progressive forms of the disease. Meningeal inflammation is a recognized risk f
Externí odkaz:
https://doaj.org/article/f0ee71fdb81b4bebb30286d645aad9af
Publikováno v:
Crystals, Vol 14, Iss 9, p 822 (2024)
We report on 2-dimensional electron gases realized in binary N-polar GaN channels on AlN on sapphire templates grown by metal–organic vapor phase epitaxy. The measured sheet carrier density of 3.8×1013 cm−2 is very close to the theoretical value
Externí odkaz:
https://doaj.org/article/a2682d4b21554794ac76cc31db257d7b
Autor:
Kanak Gupta, Ajay Kesharwani, Steven Rua, Saumitra Sen Singh, Catherine Siu, Larissa Jank, Matthew D. Smith, Peter A. Calabresi, Pavan Bhargava
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Multiple sclerosis (MS) has traditionally been viewed as a chronic inflammatory disease affecting the white matter of the central nervous system. However, over the past two decades, increasing evidence has highlighted the role of gray matter
Externí odkaz:
https://doaj.org/article/b4a04aa67a6049cabf791e0de66ecb51
Autor:
Fiona E. Lithander, Emma Tenison, Jan Ypinga, Angelika Halteren, Matthew D. Smith, Katherine Lloyd, Edward W. Richfield, Danielle E. Brazier, Mícheál Ó Breasail, Agnes J. Smink, Chris Metcalfe, William Hollingworth, Bas Bloem, Marten Munneke, Yoav Ben-Shlomo, Sirwan K. L. Darweesh, Emily J. Henderson
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Background People living with Parkinson’s disease experience progressive motor and non-motor symptoms, which negatively impact on health-related quality of life and can lead to an increased risk of hospitalisation. It is increasingly recog
Externí odkaz:
https://doaj.org/article/c08bee889a404c0cbd75a513caa6ab03
Autor:
Elias S. Sotirchos, Kathryn C. Fitzgerald, Carol M. Singh, Matthew D. Smith, Maria Reyes‐Mantilla, Carrie M. Hersh, Megan H. Hyland, Ryan Canissario, Sarah B. Simmons, Georgina Arrambide, Xavier Montalban, Manuel Comabella, Robert T. Naismith, Min Qiao, Lauren B. Krupp, Jacqueline A. Nicholas, Katja Akgün, Tjalf Ziemssen, Richard Rudick, Elizabeth Fisher, Robert A. Bermel, Ellen M. Mowry, Peter A. Calabresi
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 1, Pp 84-97 (2023)
Abstract Objective Evaluation of serum neurofilament light chain (sNfL), measured using high‐throughput assays on widely accessible platforms in large, real‐world MS populations, is a critical step for sNfL to be utilized in clinical practice. Me
Externí odkaz:
https://doaj.org/article/af7dafcddd2344fa8cf6fe2ae367d591
Autor:
Jennifer M. Zupancic, Matthew D. Smith, Hanna Trzeciakiewicz, Mary E. Skinner, Sean P. Ferris, Emily K. Makowski, Michael J. Lucas, Nikki McArthur, Ravi S. Kane, Henry L. Paulson, Peter M. Tessier
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Single-domain antibodies, also known as nanobodies, are broadly important for studying the structure and conformational states of several classes of proteins, including membrane proteins, enzymes, and amyloidogenic proteins. Conformational nanobodies
Externí odkaz:
https://doaj.org/article/744b44e777364c28a6fe9024584e8b23
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Bladder symptoms are common in Parkinson’s disease (PD), affecting half of all individuals. These have significant impact on quality of life as well as implications for morbidity, contributing to falls and hospital admission. Th
Externí odkaz:
https://doaj.org/article/2fbd57fd8fb04edb8fc371fd527e353a
Autor:
Emily K. Makowski, Patrick C. Kinnunen, Jie Huang, Lina Wu, Matthew D. Smith, Tiexin Wang, Alec A. Desai, Craig N. Streu, Yulei Zhang, Jennifer M. Zupancic, John S. Schardt, Jennifer J. Linderman, Peter M. Tessier
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Optimising antibody properties such as affinity can be detrimental to other key properties. Here the authors use machine learning to simplify the identification of antibodies with co-optimal levels of affinity and specificity for a clinical-stage ant
Externí odkaz:
https://doaj.org/article/0014043dced04499aebddc31d0764ef0
Autor:
Aline M. Thomas, Ethan Yang, Matthew D. Smith, Chengyan Chu, Peter A. Calabresi, Kristine Glunde, Peter C. M. van Zijl, Jeff W. M. Bulte
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background Multiple sclerosis (MS) is a neurodegenerative disease, wherein aberrant immune cells target myelin-ensheathed nerves. Conventional magnetic resonance imaging (MRI) can be performed to monitor damage to the central nervous system
Externí odkaz:
https://doaj.org/article/64f52c6b37a84bc98de8519ab2b2d3fa