Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Matthew D. Belvo"'
Autor:
María Luz de la Puente, Thomas J. Perun, Eric P. Seest, John Burnett, Andreas Kaerner, Matthew D. Belvo, Alfonso Rivera, Craig White, Thomas M. Castle, Cristina Anta, Arancha Sonia Marin, Pilar Lopez
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f48a0ccb95124978b7e9e70307ba5c7
https://doi.org/10.1515/9783110500776-004
https://doi.org/10.1515/9783110500776-004
Publikováno v:
Tetrahedron: Asymmetry. 20:1262-1266
A route for the synthesis of ( S , S )-7-amino-5-methyl-5 H -dibenzo[ b , d ]azepin-6(7 H )-one hydrochloride is disclosed. The synthesis includes a Friedel–Crafts alkylation to form the seven-membered ring and a highly efficient classical resoluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef637da2556e3e2a1f524136c7c12641
https://doi.org/10.1016/j.tetasy.2009.04.016
https://doi.org/10.1016/j.tetasy.2009.04.016
Autor:
Donald S. Risley, Jeffrey D. Williams, Matthew D. Belvo, Eric P. Seest, Joseph H. Kennedy, V. Scott Sharp
Publikováno v:
Chirality. 18:437-445
This study demonstrates the increased versatility of the Chiralcel OJ-H stationary phase when using various alcohol/acetonitrile mobile phases. This chiral stationary phase has traditionally been employed in the normal phase mode and more recently wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fef0124e78074d4a026743ac7bb790
https://doi.org/10.1002/chir.20269
https://doi.org/10.1002/chir.20269
Autor:
Roberta K. Sachs, Mark James Zweifel, Michael John Rodriguez, Matthew D. Belvo, William L. Current, Douglas J. Zeckner, Robert W Morris
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:161-164
The γ hydroxyl present in the aliphatic side chain of the natural products pseudomycin A and C′ provided a unique handle for the pH dependent side-chain deacylation. Low pH reaction conditions were used to cleave the side chain with minimal degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd52e66291e06597632ba736216eabb
https://doi.org/10.1016/s0960-894x(00)00613-2
https://doi.org/10.1016/s0960-894x(00)00613-2
Autor:
J W Paschal, Barbara Shreve Briggs, P J Baker, B G Getman, Muth William Lawrence, Robert J. Strobel, Milton J. Zmijewski, Matthew D. Belvo, C A J Kemp, Thomas J. Perun, T D Black
Publikováno v:
Journal of Industrial Microbiology and Biotechnology. 23:194-197
Raloxifene, also known as Evista®, has recently been approved for the prevention of osteoporosis. Three glucuronidated compounds: raloxifene-6-glucuronide, raloxifene-27-glucuronide, and raloxifene-6,27-diglucuronide are known metabolites of raloxif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fafee61f988080817d8322d47811a0d9
https://doi.org/10.1038/sj.jim.2900716
https://doi.org/10.1038/sj.jim.2900716
Autor:
Matthew D. Belvo, Michael Gregory Bell, Douglas Linn Gernert, V. Scott Sharp, Joseph H. Kennedy, Hannah Yu, Peter Stanley Borromeo, Timothy Alan Grese, Sally Ann Kelley, Gregory A. Stephenson, Mitchell I. Steinberg, Prabhakar Kondaji Jadhav, Jeffrey D. Williams, Karen M. Zimmerman, Rachel N. Richey, Stanley P. Kolis, Peter Ambrose Lander
Publikováno v:
Journal of Medicinal Chemistry. 50:6443-6445
A novel, potent series of indole analogs were recently developed as MR antagonists, culminating in 14. This compound represents the first MR antagonist in this class of molecules, exhibiting picomolar binding affinity and in vivo blood pressure lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7278bc07b6e6e72013351da2997c964
https://doi.org/10.1021/jm701186z
https://doi.org/10.1021/jm701186z
Autor:
Steven S. Henry, Matthew D. Belvo, Matt R. Reinhard, James A. Monn, Junliang Hao, Eric P. Seest
Publikováno v:
ChemInform. 43
An operationally simple method is presented for the conversion of fully protected amino acids to completely unprotected parent compounds including the mixed mGlu2 agonist/mGlu3 antagonist (IV).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49c3136849770770f9856dbabd9c1427
https://doi.org/10.1002/chin.201228216
https://doi.org/10.1002/chin.201228216
Autor:
Matthew D. Belvo, Daniel C. Williams, Donald C. Paul, Thomas J. Perun, Robert J. Strobel, Palaniappan Kulanthaivel
Publikováno v:
ChemInform. 30
Cdc25A assay-guided fractionation of a fermentation broth derived from a Streptomyces sp. resulted in the isolation of four novel naphthoquinones 1-4. Structures of these compounds were deduced by NMR and mass spectrometry. Two of them, 3 and 4, inco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de16e013f33b1c75fb124cb245666237
https://doi.org/10.1002/chin.199933274
https://doi.org/10.1002/chin.199933274
Autor:
Matthew D. Belvo, Guoxin Zhu, John E. Scott, Palaniappan Kulanthaivel, Anthony S. Fischl, Margaret M. Shaw, Wu-Kuang Yeh, Steve Heidler, Chuan Shih, Andrea Sussman, Xiang S. Ye, Li-Chun Chio, Robert M. Campbell, James R. Swartling, Mark A. Strege, Karen L. Huss, Doreen Ma, Tae-Sik Park, John W. Carpenter
The Pkc1-mediated cell wall integrity-signaling pathway is highly conserved in fungi and is essential for fungal growth. We thus explored the potential of targeting the Pkc1 protein kinase for developing broad-spectrum fungicidal antifungal drugs thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf24007ef773412080cd975363611ccb
https://europepmc.org/articles/PMC500880/
https://europepmc.org/articles/PMC500880/
Autor:
Deborah L. Mullen, Matthew Clemens, Thalia I. Nicas, Sheng-Bin Peng, Richard Craig Thompson, Eddie L. Angleton, Feng Zheng, Palaniappan Kulanthaivel, Matthew D. Belvo, Adam Joseph Kreuzman, James R. Swartling, Louis Nickolaus Jungheim, Tim A. Smitka, Kristina L. Minton, Valentine J. Klimkowski, Mark A. Strege
Publikováno v:
The Journal of biological chemistry. 279(35)
Signal peptidase (SPase) I is responsible for the cleavage of signal peptides of many secreted proteins in bacteria. Because of its unique physiological and biochemical properties, it serves as a potential target for development of novel antibacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cab7394b77c89219d23b84885dc4d03
https://pubmed.ncbi.nlm.nih.gov/15173160
https://pubmed.ncbi.nlm.nih.gov/15173160