Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Matthew, Spock"'
Autor:
Sichen Chang, Jonathan W. Dickerson, Baker Logan A, Thomas M. Bridges, Craig W. Lindsley, Darren W. Engers, Aidong Qi, Jerri M. Rook, Aaron M. Bender, P. Jeffrey Conn, Katrina A. Bollinger, Colleen M. Niswender, Changho Han, Alice L. Rodriguez, Trever R Carter, Li Peng, Julie L. Engers, Jordan C. O’Neill, Matthew Spock, Katherine J. Watson
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein, we report the SAR leading to the discovery of VU6028418, a potent M(4) mAChR antagonist with high subtype-selectivity and attractive DMPK properties in vitro and in vivo across multiple species. VU6028418 was subsequently ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388290e5061b99e6a85f95357b9a3b32
https://doi.org/10.1021/acsmedchemlett.1c00363
https://doi.org/10.1021/acsmedchemlett.1c00363
Publikováno v:
ACS Chemical Neuroscience. 11:3955-3967
Because of its remarkable potency and relative ease of synthesis, carfentanil (1) has recently emerged as a problematic contaminant in other drugs of abuse. Carfentanil and its close analogs, currently approved only for large animal veterinary medici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1506f23c9f5adf0b50c577b3042a0b
https://doi.org/10.1021/acschemneuro.0c00441
https://doi.org/10.1021/acschemneuro.0c00441
Autor:
Aaron M, Bender, Trever R, Carter, Matthew, Spock, Alice L, Rodriguez, Jonathan W, Dickerson, Jerri M, Rook, Sichen, Chang, Aidong, Qi, Christopher C, Presley, Darren W, Engers, Joel M, Harp, Thomas M, Bridges, Colleen M, Niswender, P Jeffrey, Conn, Craig W, Lindsley
Publikováno v:
Bioorganicmedicinal chemistry letters. 56
In this manuscript, we report a series of chiral 6-azaspiro[2.5]octanes and related spirocycles as highly potent and selective antagonists of the muscarinic acetylcholine receptor subtype 4 (mAChR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::15d71c45fc9259c6cf1b62b08759c9b1
https://pubmed.ncbi.nlm.nih.gov/34838649
https://pubmed.ncbi.nlm.nih.gov/34838649
Autor:
Jerri M. Rook, P. Jeffrey Conn, Aidong Qi, Aaron M. Bender, Matthew Spock, Colleen M. Niswender, Thomas M. Bridges, Sichen Chang, Trever R Carter, Craig W. Lindsley, Joel M. Harp, Christopher C Presley, Alice L. Rodriguez, Darren W. Engers, Jonathan W. Dickerson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 56:128479
In this manuscript, we report a series of chiral 6-azaspiro[2.5]octanes and related spirocycles as highly potent and selective antagonists of the muscarinic acetylcholine receptor subtype 4 (mAChR4). Chiral separation and subsequent X-ray crystallogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e9bcf50b4cdb04cbbd84852b4ecd42f
https://doi.org/10.1016/j.bmcl.2021.128479
https://doi.org/10.1016/j.bmcl.2021.128479