Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Matthew, Purcell"'
Autor:
Jessica Nunes, Rakeb Tafesse, Charlene Mao, Matthew Purcell, Xiaokui Mo, Liwen Zhang, Meixiao Long, Matthew G. Cyr, Christoph Rader, Natarajan Muthusamy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Siglec-6 is a lectin receptor with restricted expression in the placenta, mast cells and memory B-cells. Although Siglec-6 is expressed in patients with chronic lymphocytic leukemia (CLL), its pathophysiological role has not been elucidated.
Externí odkaz:
https://doaj.org/article/77c2a2030f1740c4a3efc4a6ce473897
Publikováno v:
Ecological Processes, Vol 9, Iss 1, Pp 1-9 (2020)
Abstract Background Most studies on plant invasion consider the enemy release hypothesis when analyzing native habitats. However, the lower performance of invasive species in the native habitats can be the result of unfavorable soil conditions in the
Externí odkaz:
https://doaj.org/article/2b7ddc098be44ba0b7f40ead111285c1
Autor:
Steven Sher, Ethan Whipp, Janek Walker, Pu Zhang, Larry Beaver, Katie Williams, Shelley Orwick, Janani Ravikrishnan, Brandi Walker, Elizabeth Perry, Charles Gregory, Matthew Purcell, Alexander Pan, Pearlly Yan, Lapo Alinari, Amy J. Johnson, Melanie M. Frigault, Joy M. Greer, Ahmed Hamdy, Raquel Izumi, Xiaokui Mo, Deepa Sampath, Jennifer Woyach, James Blachly, John C. Byrd, Rosa Lapalombella
Publikováno v:
Leukemia. 37:326-338
Chronic lymphocytic leukemia (CLL) is effectively treated with targeted therapies including Bruton tyrosine kinase inhibitors and BCL2 antagonists. When these become ineffective, treatment options are limited. Positive transcription elongation factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a868428a2ac8c2b3894afc9dce8d9d
https://doi.org/10.1038/s41375-022-01758-z
https://doi.org/10.1038/s41375-022-01758-z
Autor:
Jessica Nunes, Charlene Mao, Matthew Purcell, Elizabeth Perry, Liwen Zhang, Xiaokui Mo, Matthew Cyr, Meixiao Long, John Byrd, Christoph Rader, Natarajan Muthusamy
Publikováno v:
Cancer Research. 83:2966-2966
Objectives of the Study: Bispecific antibodies (BsAbs) are a class of immunotherapy drugs that facilitate targeted killing of cancer cells. Here, we report therapeutic potential of a novel Siglec-6/CD3 targeted bsAb against chronic lymphocytic leukem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b971c9ea6ca162feb0aa38bb5e828b65
https://doi.org/10.1158/1538-7445.am2023-2966
https://doi.org/10.1158/1538-7445.am2023-2966
Autor:
Kristin L Koenig, Colin Brame, Steven Sher, Larry Beaver, Casey B. Cempre, Katie Williams, Matthew Purcell, Bonnie Harrington, Yi Chen, Felai Tan, Stephen P. Anthony, Yu Chen, Yue Shen, John C. Byrd, Rosa Lapalombella
Publikováno v:
Blood. 140:9068-9069
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf099dfec610634bbe80557dfdc97180
https://doi.org/10.1182/blood-2022-170578
https://doi.org/10.1182/blood-2022-170578
Autor:
Steven Sher, Raquel Izumi, Ahmed Hamdy, John C. Byrd, Pearlly S. Yan, Brandi R. Walker, Larry Beaver, Rosa Lapalombella, Amy J. Johnson, Katie Williams, Melanie M. Frigault, Joy M. Greer, James S. Blachly, Alexander Pan, Charles Thomas Gregory, Matthew Purcell, Stuart Hwang, Shelley Orwick
Publikováno v:
Blood. 138:270-270
Background: Chronic Lymphocytic Leukemia (CLL) is a genetically heterogeneous disease characterized by clonal expansion of B-lymphocytes that induce secondary immune suppression. CLL is now treated with inhibitors of Bruton tyrosine kinase (BTK) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65e672ee0965ed4ea5b57a45d555a2fd
https://doi.org/10.1182/blood-2021-153812
https://doi.org/10.1182/blood-2021-153812
Autor:
Darren J. Fowler, Edward R. Tayton, Gordon Blunn, JO Smith, Kevin M. Shakesheff, Stuart A. Lanham, Steven M. Howdle, Matthew Purcell, Douglas G. Dunlop, Richard O.C. Oreffo, Allen E. Goodship
Publikováno v:
Journal of Biomedical Materials Research Part A. 103:1346-1356
The development of an osteogenic bone graft substitute has important practical and cost implications in many branches of medicine where bone regeneration is required. Previous in vitro and small animal (murine) in vivo studies highlighted a porous hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1b2559a854d7e2b7afab8c528516be2
https://doi.org/10.1002/jbm.a.35279
https://doi.org/10.1002/jbm.a.35279
Autor:
Matthew Purcell, Joseph A. M. Steele, Steven M. Howdle, Charlotte K. Williams, Kevin M. Shakesheff, Min Tang, Alexander Bismarck, Koon-Yang Lee, Seth D. McCullen, Molly M. Stevens
Publikováno v:
Macromolecules. 46:8136-8143
A series of random copolymers were synthesized via the copolymerization of a carbohydrate lactone, acetic acid 5-acetoxy-6-oxotetrahydropyran-2-yl methyl ester (1), and e-caprolactone. The copolymers were characterized by nuclear magnetic resonance (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce41dedb375d4154132f0b4d1db81bcd
https://doi.org/10.1021/ma401439z
https://doi.org/10.1021/ma401439z
Autor:
A Aarvold, Edward R. Tayton, Steven M. Howdle, Kevin M. Shakesheff, Adam Briscoe, Matthew Purcell, Richard O.C. Oreffo, JO Smith, Douglas G. Dunlop, Janos M. Kanczler
Publikováno v:
Journal of Biomedical Materials Research Part A. 102:2613-2624
Previous in vitro work demonstrated porous PLA and PLGA both had the mechanical strength and sustained the excellent skeletal stem cell (SSC) growth required of an osteogenic bonegraft substitute, for use in impaction bone grafting. The purpose of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a8cea1cb468853c4527e7b5eb8135fd
https://doi.org/10.1002/jbm.a.34926
https://doi.org/10.1002/jbm.a.34926