Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Matthew, Hoare"'
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Chrysa Kapeni, Eilidh Rivers, Carolin M Sauer, Flavio Beke, Stephen J Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Ghodsinia, Changtai Li, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E Richardson, Brian Huntly, David R Spring, Mikkel-Ole Skjoedt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2233-2261 (2024)
Abstract We have developed and validated a highly specific, versatile antibody to the extracellular domain of human LGR5 (α-LGR5). α-LGR5 detects LGR5 overexpression in >90% of colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pre-B-ALL t
Externí odkaz:
https://doaj.org/article/4df981d9b6cb481e9115536caaf2c410
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Chrysa Kapeni, Eilidh Rivers, Carolin M Sauer, Flavio Beke, Stephen J Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Ghodsinia, Changtai Li, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E Richardson, Brian Huntly, David R Spring, Mikkel-Ole Skjoedt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 11, Pp 3026-3026 (2024)
Externí odkaz:
https://doaj.org/article/de85458260f0462188f26c6b70c4d232
Autor:
Alex L. Wilkinson, Samuel Hulme, James I. Kennedy, Emily R. Mann, Paul Horn, Emma L. Shepherd, Kelvin Yin, Marco Y.W. Zaki, Gareth Hardisty, Wei-Yu Lu, Pia Rantakari, David H. Adams, Marko Salmi, Matthew Hoare, Daniel A. Patten, Shishir Shetty
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107966- (2023)
Summary: Liver sinusoidal endothelial cells (LSEC) undergo significant phenotypic change in chronic liver disease (CLD), and yet the factors that drive this process and the impact on their function as a vascular barrier and gatekeeper for immune cell
Externí odkaz:
https://doaj.org/article/58c0bb4699c74d3e8cde69d28ccda647
Autor:
Gabriella Assante, Sriram Chandrasekaran, Stanley Ng, Aikaterini Tourna, Carolina H. Chung, Kowsar A. Isse, Jasmine L. Banks, Ugo Soffientini, Celine Filippi, Anil Dhawan, Mo Liu, Steven G. Rozen, Matthew Hoare, Peter Campbell, J. William O. Ballard, Nigel Turner, Margaret J. Morris, Shilpa Chokshi, Neil A. Youngson
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Background The incidence of non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is increasing worldwide, but the steps in precancerous hepatocytes which lead to HCC driver mutations are not well understood. He
Externí odkaz:
https://doaj.org/article/4c59d9255acd4dbe97a0e6aee280b26c
Autor:
Lorena Escudero Sanchez, Leonardo Rundo, Andrew B. Gill, Matthew Hoare, Eva Mendes Serrao, Evis Sala
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Radiomic image features are becoming a promising non-invasive method to obtain quantitative measurements for tumour classification and therapy response assessment in oncological research. However, despite its increasingly established applica
Externí odkaz:
https://doaj.org/article/b37af1e9968a49eb8272a6243d4ac728
Autor:
Gabriella Assante, Sriram Chandrasekaran, Stanley Ng, Aikaterini Tourna, Carolina H. Chung, Kowsar A. Isse, Jasmine L. Banks, Ugo Soffientini, Celine Filippi, Anil Dhawan, Mo Liu, Steven G. Rozen, Matthew Hoare, Peter Campbell, J. William O. Ballard, Nigel Turner, Margaret J. Morris, Shilpa Chokshi, Neil A. Youngson
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/eb93debd63754739be2c1d678c35747f
Autor:
Aled J. Parry, Matthew Hoare, Dóra Bihary, Robert Hänsel-Hertsch, Stephen Smith, Kosuke Tomimatsu, Elizabeth Mannion, Amy Smith, Paula D’Santos, I. Alasdair Russell, Shankar Balasubramanian, Hiroshi Kimura, Shamith A. Samarajiwa, Masashi Narita
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Notch can drive senescence in a cell contact dependent manner. Here the authors show that NOTCH signalling can modulate chromatin structure autonomously and non-autonomously via the JAG1-NOTCH-HMGA1 interplay during senescence.
Externí odkaz:
https://doaj.org/article/0085ce66095d4d51b112d11335833dab
Autor:
Masashi Narita, Adelyne Chan, Haoran Zhu, Masako Narita, Liam Cassidy, Andrew Young, Camino Bermejo-Rodriguez, Aleksandra Janowska, Naoki oshimori, Lars Zender, Sarah Aitken, Matthew Hoare
Oncogenic RAS-induced senescence (OIS) is an autonomous tumour suppressor mechanism associated with pre-malignancy1-3. Achieving this phenotype typically requires a high level of oncogenic stress, yet the phenotype provoked by lower oncogenic dosage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d52e8c2353b1cd4fd130fe12946714a2
https://doi.org/10.21203/rs.3.rs-2842963/v1
https://doi.org/10.21203/rs.3.rs-2842963/v1
Autor:
Matthew Hoare, Jake Mann
Publikováno v:
Liver International. 42:1823-1835
Understanding the genetics of liver disease has the potential to facilitate clinical risk stratification. We recently identified acquired somatic mutations in six genes and one lncRNA in pre-existing fatty liver disease. We hypothesised that germline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547f00f181769fa963c940b420b82873
https://doi.org/10.1111/liv.15283
https://doi.org/10.1111/liv.15283
Autor:
Matthew Hoare
Mouse models have been fundamental to many significant mechanistic findings that underpin our understanding of the pathophysiology of liver disease. The ability to manipulate genes and pathways allowing us to establish causation, makes them an invalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39784747f2e9e760f823eb3bad8db77