Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mattheus, Froeyen"'
Autor:
Piet Herdewijn, Daryna Smyrnova, Mohitosh Maiti, Amutha Ramaswamy, Arnout Ceulemans, Mattheus Froeyen
Publikováno v:
Journal of chemical theory and computation. 13(10)
Xylo-nucleic acid (XyloNA) is a synthetic analogue of ribo-nucleic acid (RNA), where the ribose sugar has been replaced by xylose. We present a molecular dynamics study of the conformational evolution of XyloNA double strand oligomers derived from A-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9067907b8d7c89bba3fcd17a86b36f05
https://pubmed.ncbi.nlm.nih.gov/28742346
https://pubmed.ncbi.nlm.nih.gov/28742346
Autor:
Mattheus Froeyen, Piet Herdewijn, R. Abou El Asrar, Jef Rozenski, P. Srivastava, Mikhail Abramov, Christine Knies, Helmut Rosemeyer
The search for prebiotic, nucleic acid precursors is, at its best, a speculative undertaking. Given the complex structure of RNA, it is not very likely that RNA was the first information system in the universe and thus finding possible precursor/s i.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e48102db0e32e12a2d7a667e1eb408
https://lirias.kuleuven.be/handle/123456789/507030
https://lirias.kuleuven.be/handle/123456789/507030
Autor:
Hélène Munier-Lehmann, Piet Herdewijn, Ahmed Haouz, Veerle Vanheusden, Marc Delarue, Mattheus Froeyen, Serge Van Calenbergh
Publikováno v:
Journal of Biological Chemistry. 278:4963-4971
The chemical synthesis of new compounds designed as inhibitors of Mycobacterium tuberculosis TMP kinase (TMPK) is reported. The synthesis concerns TMP analogues modified at the 5-position of the thymine ring as well as a novel compound with a six-mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaf49b77226cf2c82b9769e18fcaf62a
https://doi.org/10.1074/jbc.m209630200
https://doi.org/10.1074/jbc.m209630200
Publikováno v:
Bioconjugate Chemistry. 13:333-350
Ribonuclease mimics based on diimidazole derived constructs in combination with or without additional amino groups have been synthesized and conjugated to oligonucleotides. The imidazole moiety was used either unprotected, protected with a monomethox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f81cfc8915fff888698b77c2a5cf08
https://doi.org/10.1021/bc0155622
https://doi.org/10.1021/bc0155622
Autor:
Piet Herdewijn, Berthold Wroblowski, Mattheus Froeyen, Eveline Lescrinier, Robert Esnouf, Hans De Winter, Brigitte Allart
Publikováno v:
Helvetica Chimica Acta. 83:2153-2182
The influence of the orientation of a 3′-OH group on the conformation and stability of hexitol oligonucleotides in complexes with RNA and as single strands in aqueous solution was investigated by molecular-dynamics (MD) simulations with AMBER 4.1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78c56a94580e997dff43324c1c2f12f
https://doi.org/10.1002/1522-2675(20000906)83:9<2153::aid-hlca2153>3.0.co
https://doi.org/10.1002/1522-2675(20000906)83:9<2153::aid-hlca2153>3.0.co
Autor:
Robert Snoeck, E. De Clereq, C. Hendrix, Piet Herdewijn, J. Wang, C. Andrei, Mattheus Froeyen, Eveline Lescrinier
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0ddea9c187f0ec4e15499c0eabef7ca
https://doi.org/10.1002/chin.200148170
https://doi.org/10.1002/chin.200148170
Publikováno v:
Chemistrybiodiversity. 1(1)
TNA (alpha-L-threose nucleic acids) is potentially a natural nucleic acid, that might have acted as an evolutionary alternative of RNA. We determined the catalytic activity of hammerhead ribozymes containing a threofuranosyl-modified nucleoside at po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8000f8ee7e2d9ed66f99daa8ef6083ab
https://pubmed.ncbi.nlm.nih.gov/17191779
https://pubmed.ncbi.nlm.nih.gov/17191779
Autor:
Ahmed, Haouz, Veerle, Vanheusden, Hélène, Munier-Lehmann, Mattheus, Froeyen, Piet, Herdewijn, Serge, Van Calenbergh, Marc, Delarue
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, 2003, 278 (7), pp.4963-71. ⟨10.1074/jbc.M209630200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2003, 278 (7), pp.4963-71. ⟨10.1074/jbc.M209630200⟩
Journal of Biological Chemistry, 2003, 278 (7), pp.4963-71. ⟨10.1074/jbc.M209630200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2003, 278 (7), pp.4963-71. ⟨10.1074/jbc.M209630200⟩
The chemical synthesis of new compounds designed as inhibitors of Mycobacterium tuberculosis TMP kinase (TMPK) is reported. The synthesis concerns TMP analogues modified at the 5-position of the thymine ring as well as a novel compound with a six-mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::769cb9205cdd678b27f5f646433bde66
https://hal-pasteur.archives-ouvertes.fr/pasteur-00167043
https://hal-pasteur.archives-ouvertes.fr/pasteur-00167043
Autor:
Piet Herdewijn, Hans De Winter, Mattheus Froeyen, Eveline Lescrinier, Robert Esnouf, Brigitte Allart, Berthold Wroblowski
Publikováno v:
ChemInform. 31
The influence of the orientation of a 3′-OH group on the conformation and stability of hexitol oligonucleotides in complexes with RNA and as single strands in aqueous solution was investigated by molecular-dynamics (MD) simulations with AMBER 4.1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::827ddaea9cf13aa7ba734ff9dfd176ec
https://doi.org/10.1002/chin.200052195
https://doi.org/10.1002/chin.200052195