Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Matthes Zessin"'
Autor:
Marten A. Fischer, Al-Hassan M. Mustafa, Kristin Hausmann, Ramy Ashry, Anita G. Kansy, Magdalena C. Liebl, Christina Brachetti, Andrea Piée-Staffa, Matthes Zessin, Hany S. Ibrahim, Thomas G. Hofmann, Mike Schutkowski, Wolfgang Sippl, Oliver H. Krämer
Publikováno v:
Journal of Advanced Research, Vol 60, Iss , Pp 201-214 (2024)
Introduction: Posttranslational modification of proteins by reversible acetylation regulates key biological processes. Histone deacetylases (HDACs) catalyze protein deacetylation and are frequently dysregulated in tumors. This has spurred the develop
Externí odkaz:
https://doaj.org/article/0bdd50c9fd09429e928b1f2b75be1138
Publikováno v:
Molbank, Vol 2022, Iss 4, p M1501 (2022)
The design of proteolysis targeting chimeras (PROTACs) has become a promising technology for modifying a protein of interest (POI) through protein degradation. Herein, we describe the synthetic pathway to develop N4-(2-amino-4-fluorophenyl)-N1-(3-{2-
Externí odkaz:
https://doaj.org/article/58225346d3044c31912e916bec8df5ec
Autor:
Emre F. Bülbül, Dina Robaa, Ping Sun, Fereshteh Mahmoudi, Jelena Melesina, Matthes Zessin, Mike Schutkowski, Wolfgang Sippl
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 968 (2023)
Histone deacetylases (HDAC) represent promising epigenetic targets for several diseases including different cancer types. The HDAC inhibitors approved to date are pan-HDAC inhibitors and most show a poor selectivity profile, side effects, and in part
Externí odkaz:
https://doaj.org/article/e3586201481146dc87ec379763db81a5
Autor:
Matthes Zessin, Marat Meleshin, Sebastian Hilscher, Cordelia Schiene-Fischer, Cyril Barinka, Manfred Jung, Mike Schutkowski
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7416 (2023)
Lysine deacetylases, like histone deacetylases (HDACs) and sirtuins (SIRTs), are involved in many regulatory processes such as control of metabolic pathways, DNA repair, and stress responses. Besides robust deacetylase activity, sirtuin isoforms SIRT
Externí odkaz:
https://doaj.org/article/198a48185cf74616a0dc7b18a61f561d
Autor:
Zsófia Kutil, Jana Mikešová, Matthes Zessin, Marat Meleshin, Zora Nováková, Glenda Alquicer, Alan Kozikowski, Wolfgang Sippl, Cyril Bařinka, Mike Schutkowski
Publikováno v:
ACS Omega, Vol 4, Iss 22, Pp 19895-19904 (2019)
Externí odkaz:
https://doaj.org/article/3ee89cddfa29420a99c367293a65dbc0
Autor:
Emre F. Bülbül, Jelena Melesina, Hany S. Ibrahim, Mohamed Abdelsalam, Anita Vecchio, Dina Robaa, Matthes Zessin, Mike Schutkowski, Wolfgang Sippl
Publikováno v:
Molecules, Vol 27, Iss 8, p 2526 (2022)
Class I histone deacetylases, HDAC1, HDAC2, and HDAC3, represent potential targets for cancer treatment. However, the development of isoform-selective drugs for these enzymes remains challenging due to their high sequence and structural similarity. I
Externí odkaz:
https://doaj.org/article/05b8cc97c3804454871db793df609555
Autor:
Hany S. Ibrahim, Mohamed Abdelsalam, Yanira Zeyn, Matthes Zessin, Al-Hassan M. Mustafa, Marten A. Fischer, Patrik Zeyen, Ping Sun, Emre F. Bülbül, Anita Vecchio, Frank Erdmann, Matthias Schmidt, Dina Robaa, Cyril Barinka, Christophe Romier, Mike Schutkowski, Oliver H. Krämer, Wolfgang Sippl
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 369 (2021)
Class I histone deacetylases (HDACs) are key regulators of cell proliferation and they are frequently dysregulated in cancer cells. We report here the synthesis of a novel series of class-I selective HDAC inhibitors (HDACi) containing a 2-aminobenzam
Externí odkaz:
https://doaj.org/article/cda02f79522b4db9818bcc7089f64abf
Autor:
Ping Sun, Jing Wang, Khadija S. Khan, Weiqin Yang, Billy Wai-Lung Ng, Nikita Ilment, Matthes Zessin, Emre F. Bülbül, Dina Robaa, Frank Erdmann, Matthias Schmidt, Christophe Romier, Mike Schutkowski, Alfred Sze-Lok Cheng, Wolfgang Sippl
Publikováno v:
Journal of Medicinal Chemistry. 65:16313-16337
Histone deacetylases (HDACs) are epigenetic regulators and additionally control the activity of non-histone substrates. We recently demonstrated that inhibition of HDAC8 overexpressed in various of cancers reduces hepatocellular carcinoma tumorigenic
Autor:
Diana Kalbas, Marat Meleshin, Sandra Liebscher, Matthes Zessin, Jelena Melesina, Cordelia Schiene-Fischer, Emre Fatih Bülbül, Frank Bordusa, Wolfgang Sippl, Mike Schutkowski
Publikováno v:
Biochemistry. 61:1705-1722
Sirtuins are protein deacylases regulating metabolism and stress responses and implicated in aging-related diseases. Modulators of the human sirtuins 1-7 are sought as chemical tools and potential therapeutics, for example, for treatment of cancer. W
Autor:
Sippl, Emre F. Bülbül, Dina Robaa, Ping Sun, Fereshteh Mahmoudi, Jelena Melesina, Matthes Zessin, Mike Schutkowski, Wolfgang
Publikováno v:
Pharmaceuticals; Volume 16; Issue 7; Pages: 968
Histone deacetylases (HDAC) represent promising epigenetic targets for several diseases including different cancer types. The HDAC inhibitors approved to date are pan-HDAC inhibitors and most show a poor selectivity profile, side effects, and in part