Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Matteus Krappitz"'
Autor:
Matteus Krappitz, Rishi Bhardwaj, Ke Dong, Tobias Staudner, Duygu Elif Yilmaz, Carlotta Pioppini, Parisa Westergerling, David Ruemmele, Till Hollmann, Thuy Anh Nguyen, Yiqiang Cai, Anna-Rachel Gallagher, Stefan Somlo, Sorin Fedeles
Publikováno v:
Journal of the American Society of Nephrology. 34:110-121
Autor:
Matteus, Krappitz, Rishi, Bhardwaj, Ke, Dong, Tobias, Staudner, Duygu Elif, Yilmaz, Carlotta, Pioppini, Parisa, Westergerling, David, Ruemmele, Till, Hollmann, Thuy Anh, Nguyen, Yiqiang, Cai, Anna-Rachel, Gallagher, Stefan, Somlo, Sorin, Fedeles
Publikováno v:
Journal of the American Society of Nephrology : JASN.
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations inWe engineered aExpression of active XBP1 in cultured cells bearing PC1Modulating ER chaperone function through XBP1 activity improved Pkd in a murine model of PC1, suggesti
Autor:
Anna Rachel Gallagher, Yasunobu Ishikawa, Stefan Somlo, Sakunchai Khumsubdee, Ke Dong, Robert G. Croy, Matteus Krappitz, Tobias Staudner, Denise C. Andrade, Bogdan I. Fedeles, Yiqiang Cai, Sally S. Liu, Nina Gubina, John M. Essigmann, Parisa Westergerling, Sorin V. Fedeles, Jake Campolo, Somsak Ruchirawat
Publikováno v:
SSRN Electronic Journal.
Background: Autosomal dominant polycystic kidney disease (ADPKD) is an incurable genetic disease affecting over 500,000 people in the United States and over 12 million people worldwide. If untreated, ADPKD can lead to end-stage kidney failure in abou
Autor:
Thuy N, Vien, Leo C T, Ng, Jessica M, Smith, Ke, Dong, Matteus, Krappitz, Vladimir G, Gainullin, Sorin, Fedeles, Peter C, Harris, Stefan, Somlo, Paul G, DeCaen
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Approximately 15% of autosomal dominant polycystic kidney disease (ADPKD) is caused by variants in PKD2. PKD2 encodes polycystin-2, which forms an ion channel in primary cilia and endoplasmic reticulum (ER) membranes of renal collecting duct cells. E
Autor:
Ke Dong, Vladimir G. Gainullin, Leo C. T. Ng, Jessica M. Smith, Peter C. Harris, Thuy N. Vien, Sorin V. Fedeles, Paul G. DeCaen, Matteus Krappitz, Stefan Somlo
Publikováno v:
Journal of Cell Science.
Approximately 15% of autosomal dominant polycystic kidney disease (ADPKD) is caused by variants in PKD2. PKD2 encodes polycystin-2, which forms an ion channel in primary cilia and endoplasmic reticulum (ER) membranes of renal collecting duct cells. E
Publikováno v:
Trends in molecular medicine. 22(12)
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 and PKD2, encoding polycystin-1 and polycystin-2, respectively. Optimizing the folding environment for polycystin-1 missense mutations may have a critical effect on t
Publikováno v:
Journal of Visualized Experiments : JoVE
The described methods can be used to investigate the effect of proteases on ion channels, receptors, and other plasma membrane proteins heterologously expressed in Xenopus laevis oocytes. In combination with site-directed mutagenesis, this approach p
Autor:
Regina Nacken, Nigel W. Bunnett, Jane E. Murphy, Silke Haerteis, Hyunjae Chung, Christoph Korbmacher, Matteus Krappitz, Morley D. Hollenberg, Annabel Krappitz, Wolfgang Knecht, Marko Bertog, Bettina Krueger
Publikováno v:
The Journal of biological chemistry. 289(27)
Proteolytic activation is a unique feature of the epithelial sodium channel (ENaC). However, the underlying molecular mechanisms and the physiologically relevant proteases remain to be identified. The serine protease trypsin I can activate ENaC in vi
Autor:
Megan S. Grace, Nigel W. Bunnett, Tina Marie Lieu, Silke Haerteis, Serena Materazzi, Yvette M. Wilson, Daniel P. Poole, Christoph Korbmacher, Martin Steinhoff, Peishen Zhao, Gihan Jayaweera, Matteus Krappitz, Peter McIntyre, Pierangelo Geppetti, Dane D. Jensen, Romina Nassini, Romke Bron, Carlos U. Corvera
Publikováno v:
Gastroenterology. 147(6)
Background & Aims Patients with cholestatic disease have increased systemic concentrations of bile acids (BAs) and profound pruritus. The G-protein–coupled BA receptor 1 TGR5 (encoded by GPBAR1 ) is expressed by primary sensory neurons; its activat
Autor:
Wolfgang Knecht, Annabel Krappitz, Jane E. Murphy, Silke Haerteis, Christoph Korbmacher, Matteus Krappitz, Nigel W. Bunnett
Publikováno v:
The FASEB Journal. 28
Proteolytic channel activation is a unique feature of the epithelial sodium channel (ENaC) but is not yet fully understood. The serine protease trypsin is known to activate ENaC in vitro but may no...