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Autor:
Andrea Testa (1), Sergio Dall'Angelo (1), Marco Mingarelli (1), Andrea Augello (1), Lutz Schweiger (1), Andrew Welch (1), Charles S. Elmore (2), Dana Dawson (1), Pradeep Sharma (3), Matteo Zanda (1
Publikováno v:
Contrast Media & Molecular Imaging, Vol 2018 (2018)
Contrast media and molecular imaging (Online) 2018 (2018): 1–10. doi:10.1155/2018/3064751
info:cnr-pdr/source/autori:Andrea Testa (1), Sergio Dall'Angelo (1), Marco Mingarelli (1), Andrea Augello (1), Lutz Schweiger (1), Andrew Welch (1), Charles S. Elmore (2), Dana Dawson (1), Pradeep Sharma (3) and Matteo Zanda (1,4)/titolo:Preclinical Evaluation of [18F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters/doi:10.1155%2F2018%2F3064751/rivista:Contrast media and molecular imaging (Online)/anno:2018/pagina_da:1/pagina_a:10/intervallo_pagine:1–10/volume:2018
Contrast media and molecular imaging (Online) 2018 (2018): 1–10. doi:10.1155/2018/3064751
info:cnr-pdr/source/autori:Andrea Testa (1), Sergio Dall'Angelo (1), Marco Mingarelli (1), Andrea Augello (1), Lutz Schweiger (1), Andrew Welch (1), Charles S. Elmore (2), Dana Dawson (1), Pradeep Sharma (3) and Matteo Zanda (1,4)/titolo:Preclinical Evaluation of [18F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters/doi:10.1155%2F2018%2F3064751/rivista:Contrast media and molecular imaging (Online)/anno:2018/pagina_da:1/pagina_a:10/intervallo_pagine:1–10/volume:2018
The bile acid analogue [18F]LCATD (LithoCholic Acid Triazole Derivative) is transported in vitro by hepatic uptake transporters such as OATP1B1 and NTCP and efflux transporter BSEP. In this in vivo “proof of principle” study, we tested if [18F]LC