Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications

Autor: Xinyu Zhang, Zhaohong Liu, Xiangyu Yang, Yuanqing Dong, Matteo Virelli, Giuseppe Zanoni, Edward A. Anderson, Xihe Bi

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)

Since fluoro-compounds are popular in industrial settings, efficient methods for incorporation of fluoride into organic molecules are desirable. Here, the authors developed trifluoroacetaldehyde N-tfsylhydrazone (TFHZ-Tfs) as a CF3CHN2 surrogate that

Externí odkaz: https://doaj.org/article/f16d80073b9e4ad596a828624a933cc7

BODIPY‐Labeled Cyclobutanes by Secondary C(sp 3 )−H Arylations for Live‐Cell Imaging

Autor: Jun Wu, Lutz Ackermann, Matteo Virelli, Wei Wang, Rositha Kuniyil, Marc Vendrell, Giuseppe Zanoni, Jamie I. Scott, Antonio Fernandez

Publikováno v: Virelli, M, Wang, W, Kuniyil, R, Wu, J, Zanoni, G, Fernandez Vargas, A, Scott, J, Vendrell Escobar, M & Ackermann, L 2019, ' BODIPY-Labeled Cyclobutanes by Secondary C(sp3)─H Arylations for Live-Cell Imaging ', Chemistry-A European Journal . https://doi.org/10.1002/chem.201903461
Chemistry – A European Journal

Arylated cyclobutanes were accessed by a versatile palladium-catalyzed secondary C(sp3 )-H activation, exploiting chelation assistance by modular triazoles. The C-H arylation led to cyclobutane natural product derivatives in a highly regioselective f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d06130a63183086d44784a8e0e798e
https://doi.org/10.1002/chem.201903461

Direct transformation of terminal alkynes into amidines by a silver-catalyzed four-component reaction

Autor: Giuseppe Zanoni, Xihe Bi, Binbin Liu, Edward A. Anderson, Yongquan Ning, Matteo Virelli

Publikováno v: Journal of the American Chemical Society. 141(4)

An unprecedented conversion of terminal alkynes into N-sulfonimidamides (amidines) is reported by a silver-catalyzed, one-pot, four-component reaction with TMSN3, sodium sulfinate, and sulfonyl azide. The reaction scope includes both aromatic and ali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05604b7c9efc81b27b63fa26447a102e
http://ora.ox.ac.uk/objects/uuid:

Expedient Access to 2-Benzazepines by Palladium-Catalyzed C-H Activation: Identification of a Unique Hsp90 Inhibitor Scaffold

Autor: Giuseppe Zanoni, Lorenzo Fiengo, Matteo Virelli, Elisabetta Moroni, Giorgio Colombo, Lutz Ackermann, Alessio Porta

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 24(62)

Bioactive 2-benzazepines were accessed in an atom- and step-economical manner through a versatile palladium-catalyzed C-H activation strategy. The C-H arylation required low catalyst loading and a mild base, which was reflected by a broad scope and h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4458eabfe420ae62b27209a2d226a99e
https://pubmed.ncbi.nlm.nih.gov/30136746