Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Matteo Santucci"'
Autor:
Juliana Haydeé Enriqué Steinberg, Fabiana Alejandra Rossi, Roberto Magliozzi, Laurensia Yuniati, Matteo Santucci, Mario Rossi, Daniele Guardavaccaro, Angela Lauriola
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-7 (2023)
Abstract Triple-negative breast cancer (TNBC) is a subtype of breast cancer associated with metastasis, high recurrence rate, and poor survival. The basic helix-loop-helix transcription factor SHARP1 (Split and Hairy-related Protein 1) has been ident
Externí odkaz:
https://doaj.org/article/02c30091da5d4d0f8159e02261a59c27
Autor:
Luca Costantino, Stefania Ferrari, Matteo Santucci, Outi MH Salo-Ahen, Emanuele Carosati, Silvia Franchini, Angela Lauriola, Cecilia Pozzi, Matteo Trande, Gaia Gozzi, Puneet Saxena, Giuseppe Cannazza, Lorena Losi, Daniela Cardinale, Alberto Venturelli, Antonio Quotadamo, Pasquale Linciano, Lorenzo Tagliazucchi, Maria Gaetana Moschella, Remo Guerrini, Salvatore Pacifico, Rosaria Luciani, Filippo Genovese, Stefan Henrich, Silvia Alboni, Nuno Santarem, Anabela da Silva Cordeiro, Elisa Giovannetti, Godefridus J Peters, Paolo Pinton, Alessandro Rimessi, Gabriele Cruciani, Robert M Stroud, Rebecca C Wade, Stefano Mangani, Gaetano Marverti, Domenico D'Arca, Glauco Ponterini, Maria Paola Costi
Publikováno v:
eLife, Vol 11 (2022)
Drugs that target human thymidylate synthase (hTS), a dimeric enzyme, are widely used in anticancer therapy. However, treatment with classical substrate-site-directed TS inhibitors induces over-expression of this protein and development of drug resis
Externí odkaz:
https://doaj.org/article/6b5ed787a8314e518ea035b5e470ee7c
Autor:
Angela Lauriola, Elisa Uliassi, Matteo Santucci, Maria Laura Bolognesi, Marco Mor, Laura Scalvini, Gian Marco Elisi, Gaia Gozzi, Lorenzo Tagliazucchi, Gaetano Marverti, Stefania Ferrari, Lorena Losi, Domenico D’Arca, Maria Paola Costi
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 391 (2022)
The transcriptional regulators YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) are the major downstream effectors in the Hippo pathway and are involved in cancer progression through modulation of the activit
Externí odkaz:
https://doaj.org/article/6b37af2ad3704c51b856208309d6c8c9
Autor:
Matteo Santucci, Rosaria Luciani, Eleonora Gianquinto, Cecilia Pozzi, Flavio di Pisa, Lucia dello Iacono, Giacomo Landi, Lorenzo Tagliazucchi, Stefano Mangani, Francesca Spyrakis, Maria Paola Costi
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1246 (2021)
Three open-source anti-kinetoplastid chemical boxes derived from a whole-cell phenotypic screening by GlaxoSmithKline (Tres Cantos Anti-Kinetoplastid Screening, TCAKS) were exploited for the discovery of a novel core structure inspiring new treatment
Externí odkaz:
https://doaj.org/article/dea8a1bafe16424b8a3fa4033cb94bf8
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth
Autor:
Salvatore Pacifico, Matteo Santucci, Rosaria Luciani, Puneet Saxena, Pasquale Linciano, Glauco Ponterini, Angela Lauriola, Domenico D’Arca, Gaetano Marverti, Remo Guerrini, Maria Paola Costi
Publikováno v:
Molecules, Vol 24, Iss 19, p 3493 (2019)
Thymidylate synthase (TS) is a prominent drug target for different cancer types. However, the prolonged use of its classical inhibitors, substrate analogs that bind at the active site, leads to TS overexpression and drug resistance in the clinic. In
Externí odkaz:
https://doaj.org/article/61da817c7a194f56a082b000a4c8c452
Publikováno v:
Biomolecules, Vol 9, Iss 4, p 134 (2019)
In human cells, thymidylate synthase (TS) provides the only source of 2′-deoxythymidyne-5′-monophosphate (dTMP), which is required for DNA biosynthesis. Because of its pivotal role, human TS (hTS) represents a validated target for anticancer chem
Externí odkaz:
https://doaj.org/article/3cb5055eca254bccb497506a50bf195d
Autor:
Ina Pöhner, Antonio Quotadamo, Joanna Panecka-Hofman, Rosaria Luciani, Matteo Santucci, Pasquale Linciano, Giacomo Landi, Flavio Di Pisa, Lucia Dello Iacono, Cecilia Pozzi, Stefano Mangani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Nuno Santarem, Anabela Cordeiro-da-Silva, Maria P. Costi, Alberto Venturelli, Rebecca C. Wade
Publikováno v:
Journal of Medicinal Chemistry. 65:9011-9033
The optimization of compounds with multiple targets is a difficult multidimensional problem in the drug discovery cycle. Here, we present a systematic, multidisciplinary approach to the development of selective anti-parasitic compounds. Computational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e41398a9a37d40ed6cd866693989d0d
https://doi.org/10.1021/acs.jmedchem.2c00232
https://doi.org/10.1021/acs.jmedchem.2c00232
Autor:
Stefano Santucci, Matteo Santucci
Publikováno v:
European Heart Journal Supplements. 24
For the implantation of the PM, iodized contrast medium is rarely used and to recognize the anatomical structures within which one is operating, one must resort to the interpretation of only the radiological images obtained with the use of ionizing r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a884d3bf3d7231376783db4f32736df1
https://doi.org/10.1093/eurheartjsupp/suac121.697
https://doi.org/10.1093/eurheartjsupp/suac121.697
Autor:
Stefano Santucci, Matteo Santucci
Publikováno v:
European Heart Journal Supplements. 24
The use of 3D printing in the medical field is widespread especially in the dental clinic as a support to orthodontic / implant therapy. In the training of personnel relating to cardiological diagnostic methods, can it be useful to shorten the learni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2084125352439125a9917cde64292503
https://doi.org/10.1093/eurheartjsupp/suac121.698
https://doi.org/10.1093/eurheartjsupp/suac121.698
Autor:
Luca Costantino, Stefania Ferrari, Matteo Santucci, Outi MH Salo-Ahen, Emanuele Carosati, Silvia Franchini, Angela Lauriola, Cecilia Pozzi, Matteo Trande, Gaia Gozzi, Puneet Saxena, Giuseppe Cannazza, Lorena Losi, Daniela Cardinale, Alberto Venturelli, Antonio Quotadamo, Pasquale Linciano, Lorenzo Tagliazucchi, Maria Gaetana Moschella, Remo Guerrini, Salvatore Pacifico, Rosaria Luciani, Filippo Genovese, Stefan Henrich, Silvia Alboni, Nuno Santarem, Anabela da Silva Cordeiro, Elisa Giovannetti, Godefridus J Peters, Paolo Pinton, Alessandro Rimessi, Gabriele Cruciani, Robert M Stroud, Rebecca C Wade, Stefano Mangani, Gaetano Marverti, Domenico D'Arca, Glauco Ponterini, Maria Paola Costi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdeb9c0a07f471fb49b11123dde41c43
https://doi.org/10.7554/elife.73862.sa2
https://doi.org/10.7554/elife.73862.sa2
