Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Matteo Osella"'
Autor:
Chiara Enrico Bena, Marco Del Giudice, Alice Grob, Thomas Gueudré, Mattia Miotto, Dimitra Gialama, Matteo Osella, Emilia Turco, Francesca Ceroni, Andrea De Martino, Carla Bosia
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Individual cells exhibit specific proliferative responses to changes in microenvironmental conditions. Whether such potential is constrained by the cell density throughout the growth process is however unclear. Here, we identify a theoretica
Externí odkaz:
https://doaj.org/article/2cad83971b2c45e29d0e3d3554b47278
Autor:
Ludovico Calabrese, Jacopo Grilli, Matteo Osella, Christopher P Kempes, Marco Cosentino Lagomarsino, Luca Ciandrini
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 5, p e1010059 (2022)
Growing cells adopt common basic strategies to achieve optimal resource allocation under limited resource availability. Our current understanding of such "growth laws" neglects degradation, assuming that it occurs slowly compared to the cell cycle du
Externí odkaz:
https://doaj.org/article/b7d65998dcb14391addaa6ed69b75a88
Autor:
Mayra L. Ruiz Tejada Segura, Eman Abou Moussa, Elisa Garabello, Thiago S. Nakahara, Melanie Makhlouf, Lisa S. Mathew, Li Wang, Filippo Valle, Susie S.Y. Huang, Joel D. Mainland, Michele Caselle, Matteo Osella, Stephan Lorenz, Johannes Reisert, Darren W. Logan, Bettina Malnic, Antonio Scialdone, Luis R. Saraiva
Publikováno v:
Cell Reports, Vol 38, Iss 12, Pp 110547- (2022)
Summary: The sense of smell helps us navigate the environment, but its molecular architecture and underlying logic remain understudied. The spatial location of odorant receptor genes (Olfrs) in the nose is thought to be independent of the structural
Externí odkaz:
https://doaj.org/article/7772da879f4a40c7a892b26c1629f2a6
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 12, p e1009638 (2021)
This work studies the effects of the two rounds of Whole Genome Duplication (WGD) at the origin of the vertebrate lineage on the architecture of the human gene regulatory networks. We integrate information on transcriptional regulation, miRNA regulat
Externí odkaz:
https://doaj.org/article/8541b59330fc445085cd28e667a08ded
Autor:
Marta Biondo, Cristina Panuzzo, Shahzad M. Ali, Salvatore Bozzaro, Matteo Osella, Enrico Bracco, Barbara Pergolizzi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
In aerobic organisms, oxygen is essential for efficient energy production, and it acts as the last acceptor of the mitochondrial electron transport chain and as regulator of gene expression. However, excessive oxygen can lead to production of deleter
Externí odkaz:
https://doaj.org/article/1da648d9d26742279a7e89b99b0a6359
Publikováno v:
Cancers, Vol 14, Iss 5, p 1150 (2022)
The integration of transcriptional data with other layers of information, such as the post-transcriptional regulation mediated by microRNAs, can be crucial to identify the driver genes and the subtypes of complex and heterogeneous diseases such as ca
Externí odkaz:
https://doaj.org/article/ea4c1361f2cd4160a7872b24e3f22c5b
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Transcription factors (TFs) exert their regulatory action by binding to DNA with specific sequence preferences. However, different TFs can partially share their binding sequences due to their common evolutionary origin. This “redundancy”
Externí odkaz:
https://doaj.org/article/41a22669d12d43a38f9d2da0e52d2598
Publikováno v:
Cell Reports, Vol 25, Iss 3, Pp 761-771.e4 (2018)
Summary: Understanding the classic problem of how single E. coli cells coordinate cell division with genome replication would open the way to addressing cell-cycle progression at the single-cell level. Recent studies produced new data, but the contra
Externí odkaz:
https://doaj.org/article/278343d9857b4b4cbc5ed99eacff9cf2
Publikováno v:
Cancers, Vol 12, Iss 12, p 3799 (2020)
Topic modeling is a widely used technique to extract relevant information from large arrays of data. The problem of finding a topic structure in a dataset was recently recognized to be analogous to the community detection problem in network theory. L
Externí odkaz:
https://doaj.org/article/e4748bb196414d0fa8032aab05fea8fa
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
In physics, it is customary to represent the fluctuations of a stochastic system at steady state in terms of linear response to small random perturbations. Previous work has shown that the same framework describes effectively the trade-off between ce
Externí odkaz:
https://doaj.org/article/856910e3335144a3a0f46e9c5b86766c