Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Matteo Gentili"'
Autor:
Shira Weingarten-Gabbay, Da-Yuan Chen, Siranush Sarkizova, Hannah B. Taylor, Matteo Gentili, Gabrielle M. Hernandez, Leah R. Pearlman, Matthew R. Bauer, Charles M. Rice, Karl R. Clauser, Nir Hacohen, Steven A. Carr, Jennifer G. Abelin, Mohsan Saeed, Pardis C. Sabeti
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113596- (2024)
Summary: Targeted synthetic vaccines have the potential to transform our response to viral outbreaks, yet the design of these vaccines requires a comprehensive knowledge of viral immunogens. Here, we report severe acute respiratory syndrome coronavir
Externí odkaz:
https://doaj.org/article/db8ea015b89d430fb372f8118aea4ea2
Autor:
Matteo Gentili, Bingxu Liu, Malvina Papanastasiou, Deborah Dele-Oni, Marc A. Schwartz, Rebecca J. Carlson, Aziz M. Al’Khafaji, Karsten Krug, Adam Brown, John G. Doench, Steven A. Carr, Nir Hacohen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
STING is an intracellular sensor of pathogen- or host-derived DNA. In this study, the authors identify an ESCRT complex that regulates STING degradation, thus acting as a homeostatic regulator of STING signalling and type-I interferon responses.
Externí odkaz:
https://doaj.org/article/d27c75d5f7194b308e5471c9ab586aee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Faster, higher throughput antibody engineering methods are needed. Here the authors present CeVICA, a cell-free nanobody engineering platform using ribosome display and computational clustering analysis for in vitro selection; they use this to develo
Externí odkaz:
https://doaj.org/article/56b2b7942e424f41b5a4614d612ffcf2
A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity
Autor:
Atilio Reyes Romero, Serjey Lunev, Grzegorz M. Popowicz, Vito Calderone, Matteo Gentili, Michael Sattler, Jacek Plewka, Michał Taube, Maciej Kozak, Tad A. Holak, Alexander S. S. Dömling, Matthew R. Groves
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Romero et al. perform NMR-based screening of 1500 fragments to identify fragments that bind at the oligomeric interface of malate dehydrogenase (MDH). Their study indicates an allosteric mechanism impacting enzymatic activity, paving the way for deve
Externí odkaz:
https://doaj.org/article/f14c722416964fa8b99c79a63335b872
Autor:
Chuangqi Wang, Yijia Li, Paulina Kaplonek, Matteo Gentili, Stephanie Fischinger, Kathryn A. Bowman, Moshe Sade-Feldman, Kyle R. Kays, James Regan, James P. Flynn, Marcia B. Goldberg, Nir Hacohen, Michael R. Filbin, Douglas A. Lauffenburger, Galit Alter, Jonathan Z. Li
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Persistent SARS-CoV-2 replication and systemic dissemination are linked to increased COVID-19 disease severity and mortality. However, the precise immune profiles that track with enhanced viral clearance, particularly from systemic RNAemia,
Externí odkaz:
https://doaj.org/article/4fedcf9b53004f06aeb4f5c246c1eec3
Autor:
Yuchen Zhang, Rui Guo, Sharon H. Kim, Hardik Shah, Shuting Zhang, Jin Hua Liang, Ying Fang, Matteo Gentili, Colin N. O’ Leary, Steven J. Elledge, Deborah T. Hung, Vamsi K. Mootha, Benjamin E. Gewurz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Viruses rely on host metabolism for replication. Here, the authors perform transcriptional and metabolomic analyses at 8 hours after SARS-CoV-2 infection and find that the virus alters host folate and one-carbon metabolism at a post-transcriptional l
Externí odkaz:
https://doaj.org/article/f88a9b0dc0a044b0976adf1dcbbff5ba
Autor:
Nastassja Burrini, Mario D’Ambrosio, Matteo Gentili, Roberta Giaquinto, Veronica Settimelli, Cristina Luceri, Marzia Cirri, Oscar Francesconi
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 235 (2023)
Niosomes are a potential tool for the development of active targeted drug delivery systems (DDS) for cancer therapy because of their excellent behaviour in encapsulating antitumorals and the possibility to easily functionalise their surface with targ
Externí odkaz:
https://doaj.org/article/e81dd2d85a5b463ba22568c4524020d8
Autor:
Michael R. Filbin, Arnav Mehta, Alexis M. Schneider, Kyle R. Kays, Jamey R. Guess, Matteo Gentili, Bánk G. Fenyves, Nicole C. Charland, Anna L.K. Gonye, Irena Gushterova, Hargun K. Khanna, Thomas J. LaSalle, Kendall M. Lavin-Parsons, Brendan M. Lilley, Carl L. Lodenstein, Kasidet Manakongtreecheep, Justin D. Margolin, Brenna N. McKaig, Maricarmen Rojas-Lopez, Brian C. Russo, Nihaarika Sharma, Jessica Tantivit, Molly F. Thomas, Robert E. Gerszten, Graham S. Heimberg, Paul J. Hoover, David J. Lieb, Brian Lin, Debby Ngo, Karin Pelka, Miguel Reyes, Christopher S. Smillie, Avinash Waghray, Thomas E. Wood, Amanda S. Zajac, Lori L. Jennings, Ida Grundberg, Roby P. Bhattacharyya, Blair Alden Parry, Alexandra-Chloé Villani, Moshe Sade-Feldman, Nir Hacohen, Marcia B. Goldberg
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100287- (2021)
Summary: Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain poorly understood. We analyze several thousand plasma proteins longitudinally in 306 COVID-19 patients and 78 symptomatic controls, uncovering immune and non-imm
Externí odkaz:
https://doaj.org/article/c08db236b856403b84bbe1685b762818
Autor:
Xavier Lahaye, Takeshi Satoh, Matteo Gentili, Silvia Cerboni, Aymeric Silvin, Cécile Conrad, Abdelhakim Ahmed-Belkacem, Elisa C. Rodriguez, Jean-François Guichou, Nathalie Bosquet, Matthieu Piel, Roger Le Grand, Megan C. King, Jean-Michel Pawlotsky, Nicolas Manel
Publikováno v:
Cell Reports, Vol 15, Iss 4, Pp 879-892 (2016)
During the early phase of replication, HIV reverse transcribes its RNA and crosses the nuclear envelope while escaping host antiviral defenses. The host factor Cyclophilin A (CypA) is essential for these steps and binds the HIV capsid; however, the m
Externí odkaz:
https://doaj.org/article/fe92c4c74c7046739a91e7a5b56b2a1a
Autor:
Stefano Dugheri, Alessandro Bonari, Matteo Gentili, Giovanni Cappelli, Ilenia Pompilio, Costanza Bossi, Giulio Arcangeli, Marcello Campagna, Nicola Mucci
Publikováno v:
Molecules, Vol 23, Iss 8, p 1869 (2018)
High-throughput screening of samples is the strategy of choice to detect occupational exposure biomarkers, yet it requires a user-friendly apparatus that gives relatively prompt results while ensuring high degrees of selectivity, precision, accuracy
Externí odkaz:
https://doaj.org/article/40b8d48260fa48c9b530178634810277