Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Matteo G. Levisetti"'
Autor:
Alex Histed, Raymond Moniz, Zohra Merazga, Steve Quayle, Mark Haydock, Matteo G. Levisetti, Anish Suri, Luke Witt, Saso Cemerski, Kenneth J. Pienta, Natasha Girgis, Steven Hatfield, Fan Zhao, Kristin Yeung, John F. Ross, Jason Brown, Christie Zhang, Fulvio Diaz, Wynona Bautista
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundWilms' Tumor 1 (WT1) was ranked as the highest priority antigen for therapeutic targeting in an effort by the National Cancer Institute. Development of novel modalities targeting WT1 provide a significant opportunity to address high unmet m
Autor:
Matteo G. Levisetti, James F. Mohan, Boris Calderon, Jeremy Herzog, Shirley J. Petzold, Emil R. Unanue
Publikováno v:
Nature immunology
In addition to the genetic framework, there are two other critical requirements for the development of tissue-specific autoimmune disease. First, autoreactive T cells need to escape thymic negative selection. Second, they need to find suitable condit
Publikováno v:
Diabetes
OBJECTIVE—Weak major histocompatibility complex (MHC) binding of self-peptides has been proposed as a mechanism that may contribute to autoimmunity by allowing for escape of autoreactive T-cells from the thymus. We examined the relationship between
Publikováno v:
Current Opinion in Immunology. 20:105-110
One seminal aspect in autoimmune diabetes is antigen presentation of beta cell antigens by the diabetes-propensity class II histocompatibility molecules. The binding properties of I-Ag7 molecules are reviewed here and an emphasis is placed on their s
Publikováno v:
The Journal of Immunology. 178:6051-6057
Several naturally occurring anti-insulin CD4 T cells were isolated from islet infiltrates of NOD mice. In accordance with the results of others, these T cells recognized the segment of the β-chain from residues 9–23. Peptides encompassing the B:(9
Autor:
Craig A. Byersdorfer, Scott B. Lovitch, Javier A. Carrero, Matteo G. Levisetti, Emil R. Unanue, Zheng Pu, Anish Suri
Publikováno v:
Immunologic Research. 32:267-292
We discuss three areas of antigen presentation and macrophage biology being investigated in the laboratory. Using hen egg-white lysozyme as a protein antigen, all the segments of the molecules selected by the class II histocompatibility molecule I-A(
Autor:
Kathy E. Frederick, Lucie N. Beaudet, Curtis A. Parvin, Denise A. Dorsey, Robert E. Schmidt, Santiago B. Plurad, Matteo G. Levisetti
Publikováno v:
The American Journal of Pathology. 163:2077-2091
To address the pathogenesis of diabetic autonomic neuropathy, we have examined the sympathetic nervous system in non-obese diabetic (NOD) and streptozotocin (STZ)-induced diabetic mice, two models of type 1 diabetes, and the db/db mouse, a model of t
Autor:
Noreen Ahmed, Kenneth S. Polonsky, Craig B. Thompson, Louis H. Philipson, Matteo G. Levisetti, Douglas Hanahan, Yun-Ping Zhou, Anshu A. Mittal, Vytautas P. Bindokas, Michael W. Roe, Diane Ostrega, Aaron C. Baldwin, John C. Pena, W. Pugh
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 278:E340-E351
To study effects of Bcl-xLin the pancreatic β-cell, two transgenic lines were produced using different forms of the rat insulin promoter. Bcl-xLexpression in β-cells was increased 2- to 3-fold in founder (Fd) 1 and over 10-fold in Fd 2 compared wit
Autor:
Craig L. Wardrip, David Bruce, Xiantang Li, Betty Theriault, Jeffrey A. Bluestone, Horatio Rilo, J. R. Thistlethwaite, Gregory L. Szot, Matteo G. Levisetti, Philip Padrid, Gary S. Gray
Publikováno v:
Transplantation. 68:331-337
Background. Insulin-dependent diabetes mellitus (IDDM) is the second most prevalent chronic illness of children. Investigation of the treatment of IDDM is hindered by the lack of a reproducible and easily maintained non-human primate model of this di
Autor:
Seamus Sreenan, Aaron C. Baldwin, Kenneth S. Polonsky, Matteo G. Levisetti, W. Pugh, Anthony Pick
Publikováno v:
Diabetes. 48:989-996
To determine whether loss of beta-cell mass and function in the NOD mouse occurs gradually, beginning after the onset of insulitis, or abruptly, just before the onset of overt diabetes, beta-cell mass and rates of beta-cell proliferation and insulin