Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Matteo G Boretto"'
One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids
Autor:
Maarten H. Geurts, Shashank Gandhi, Matteo G. Boretto, Ninouk Akkerman, Lucca L. M. Derks, Gijs van Son, Martina Celotti, Sarina Harshuk-Shabso, Flavia Peci, Harry Begthel, Delilah Hendriks, Paul Schürmann, Amanda Andersson-Rolf, Susana M. Chuva de Sousa Lopes, Johan H. van Es, Ruben van Boxtel, Hans Clevers
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Optimization of CRISPR/Cas9-mediated genome engineering has resulted in base editors that hold promise for mutation repair and disease modeling. Here, we demonstrate the application of base editors for the generation of complex tumor models
Externí odkaz:
https://doaj.org/article/118466422c7b4a548268957a251cfb11
Publikováno v:
Trends in Cancer. 6:1031-1043
The human female reproductive tract (FRT) is a complex system that combines series of organs, including ovaries, fallopian tubes, uterus, cervix, vagina, and vulva; each of which possesses unique cellular characteristics and functions. This versatili
Autor:
Amanda Andersson-Rolf, Maarten H. Geurts, Cayetano Pleguezuelos-Manzano, Eyleen de Poel, Matteo G Boretto, Léo Carrillo, Jeffrey M. Beekman, Hans Clevers
Prime editing is a recently reported genome editing tool employing a nickase-cas9 fused to a reverse transcriptase that directly synthesizes the desired edit at the target site. The technique holds great promise for clinical application due to its ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c69f55aaf5214503aef5368694397900
https://doi.org/10.1101/2020.10.05.325837
https://doi.org/10.1101/2020.10.05.325837