Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Matteo Cremonini"'
Autor:
Lucia Banci, Matteo Pennestri, Letizia Barbieri, Enrico Luchinat, Alessio Nocentini, Matteo Cremonini, Claudiu T. Supuran
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
Acta Crystallographica Section D Structural Biology
Acta Crystallographica Section D Structural Biology
Intracellular protein–ligand dissociation constants are measured by in-cell NMR spectroscopy by means of competition binding experiments with respect to a reference ligand. The method is applied to a set of carbonic anhydrase inhibitors, revealing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c41415cd86da59f735c68bc7252d9a3
https://doi.org/10.1107/s2059798321009037
https://doi.org/10.1107/s2059798321009037
Autor:
Enrico Luchinat, Letizia Barbieri, Lucia Banci, Alessio Nocentini, Claudiu T. Supuran, Matteo Cremonini
Publikováno v:
ACS Chemical Biology
Candidate drugs rationally designed in vitro often fail due to low efficacy in vivo caused by low tissue availability or because of unwanted side effects. To overcome the limitations of in vitro rational drug design, the binding of candidate drugs to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a57d8e183ed031fe4056a25fcf9195a
https://doi.org/10.1021/acschembio.0c00590
https://doi.org/10.1021/acschembio.0c00590
Autor:
Claudiu T. Supuran, Letizia Barbieri, Alessio Nocentini, Matteo Cremonini, Enrico Luchinat, Lucia Banci
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Ed. in English)
Structure‐based drug development is often hampered by the lack of in vivo activity of promising compounds screened in vitro, due to low membrane permeability or poor intracellular binding selectivity. Herein, we show that ligand screening can be pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d75112d18f4f5714bde00035fdebbb
https://doi.org/10.1002/ange.201913436
https://doi.org/10.1002/ange.201913436
Publikováno v:
Chemical reviews. 122(10)
A detailed knowledge of the complex processes that make cells and organisms alive is fundamental in order to understand diseases and to develop novel drugs and therapeutic treatments. To this aim, biological macromolecules should ideally be character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9676e0e9c17570a7608368bde1489dc7
https://pubmed.ncbi.nlm.nih.gov/35061391
https://pubmed.ncbi.nlm.nih.gov/35061391
Publikováno v:
Journal of Biomolecular Nmr
Journal of Biomolecular NMR
Journal of Biomolecular NMR
In-cell NMR spectroscopy provides precious structural and functional information on biological macromolecules in their native cellular environment at atomic resolution. However, the intrinsic low sensitivity of NMR imposes a big limitation in the app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc350d79e8b1a19a6249a9d00f36d2e
https://pubmed.ncbi.nlm.nih.gov/33580357
https://pubmed.ncbi.nlm.nih.gov/33580357