Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores angiogenic homeostasis and suppresses tumor progression

Autor: Antonio G. Solimando, Matteo C. Da Vià, Patrizia Leone, Paola Borrelli, Giorgio A. Croci, Paula Tabares, Andreas Brandl, Giuseppe Di Lernia, Francesco P. Bianchi, Silvio Tafuri, Torsten Steinbrunn, Alessandra Balduini, Assunta Melaccio, Simona De Summa, Antonella Argentiero, Hilka Rauert-Wunderlich, Maria A. Frassanito, Paolo Ditonno, Erik Henke, Wolfram Klapper, Roberto Ria, Carolina Terragna, Leo Rasche, Andreas Rosenwald, K. Martin Kortüm, Michele Cavo, Domenico Ribatti, Vito Racanelli, Hermann Einsele, Angelo Vacca, Andreas Beilhack

Publikováno v: Haematologica, Vol 106, Iss 7 (2020)

Interactions of malignant multiple myeloma (MM) plasma cells (MM-cells) with the microenvironment control MM-cell growth, survival, drug-resistance and dissemination. As in MM microvascular density increases in the bone marrow (BM), we investigated w

Externí odkaz: https://doaj.org/article/c2545760d0c3467b8997b010e53370db

Supplementary Figures 1-15, Supplementary Table 1 from ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment

Autor: Kenneth C. Anderson, Irene M. Ghobrial, Ruben D. Carrasco, Tomasz Sewastianik, Niccolo' Bolli, Matteo C. Da Vià, Gulden Camci-Unal, Xinchen Wu, Maria Moscvin, Yu-Tzu Tai, Kenneth Wen, Tianzeng Chen, Anil Aktas Samur, Annamaria Gullà, Yawara Kawano, Antonio Sacco, Aldo M. Roccaro, Matthew Ho, Peter G. Czarnecki, Giada Bianchi

Supplementary Figure 1 showing ROBO1 expression in primary MM cells versus normal donor bone marrow plasma cells via gene expression profiling and immunohistochemistry. Supplementary Figure 2 showing distribution of ROBO1 expression in the CoMMpass d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61bd46dd01d9ed92d4805d36ff6c55a9
https://doi.org/10.1158/2643-3230.22543528.v1

Single-Cell RNA Sequencing for the Detection of Clonotypic V(D)J Rearrangements in Multiple Myeloma

Autor: Antonio Matera, Alessio Marella, Akihiro Maeda, Matteo C. Da Vià, Francesca Lazzaroni, Sonia Fabris, Stefania Pioggia, Laura Porretti, Federico Colombo, Federica Torricelli, Antonino Neri, Elisa Taiana, Giuseppina Fabbiano, Valentina Traini, Elisa Genuardi, Daniela Drandi, Niccolò Bolli, Marta Lionetti

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 24; Pages: 15691

Multiple myeloma (MM) has a highly heterogeneous genetic background, which complicates its molecular tracking over time. Nevertheless, each MM patient’s malignant plasma cells (PCs) share unique V(D)J rearranged sequences at immunoglobulin loci, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efd1b1cc41688af0b91aa49c33b3f66

Inappropriately low hepcidin levels in patients with myelodysplastic syndrome carrying a somatic mutation of SF3B1

Autor: Ilaria Ambaglio, Luca Malcovati, Elli Papaemmanuil, Coby M. Laarakkers, Matteo G. Della Porta, Anna Gallì, Matteo C. Da Vià, Elisa Bono, Marta Ubezio, Erica Travaglino, Riccardo Albertini, Peter J. Campbell, Dorine W. Swinkels, Mario Cazzola

Publikováno v: Haematologica, Vol 98, Iss 3 (2013)

Somatic mutations of the RNA splicing machinery have been recently identified in myelodysplastic syndromes. In particular, a strong association has been found between SF3B1 mutation and refractory anemia with ring sider-oblasts, a condition character

Externí odkaz: https://doaj.org/article/060595973faf4ecaaade8d4cb70e9372

Single-Cell RNA Sequencing for the Detection of Clonotypic V(D)J Rearrangements in Multiple Myeloma.

Autor: Matera, Antonio¹ (AUTHOR), Marella, Alessio¹ (AUTHOR), Maeda, Akihiro¹ (AUTHOR), Da Vià, Matteo C.² (AUTHOR), Lazzaroni, Francesca² (AUTHOR), Fabris, Sonia² (AUTHOR), Pioggia, Stefania² (AUTHOR), Porretti, Laura² (AUTHOR), Colombo, Federico² (AUTHOR), Torricelli, Federica³ (AUTHOR), Neri, Antonino⁴ (AUTHOR), Taiana, Elisa² (AUTHOR), Fabbiano, Giuseppina² (AUTHOR), Traini, Valentina¹ (AUTHOR), Genuardi, Elisa⁵ (AUTHOR), Drandi, Daniela⁵ (AUTHOR), Bolli, Niccolò^1,2 (AUTHOR) niccolo.bolli@unimi.it, Lionetti, Marta¹ (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Dec2022, Vol. 23 Issue 24, p15691. 9p.