Noncanonical-NF-κB activation and DDX3 inhibition reduces the HIV-1 reservoir by elimination of latently infected cells ex-vivo

Autor: Jade Jansen, Stefanie Kroeze, Shirley Man, Matteo Andreini, Jan-Willem Bakker, Claudio Zamperini, Alessia Tarditi, Neeltje A. Kootstra, Teunis B. H. Geijtenbeek

Publikováno v: Microbiology Spectrum, Vol 12, Iss 1 (2024)

ABSTRACT Latency reversal and subsequent elimination of the human immunodeficiency virus-1 (HIV-1) reservoir using a combination of compounds with different mechanisms of action are considered a promising tool for HIV-1 cure. Here, we analyzed HIV-1

Externí odkaz: https://doaj.org/article/d0560039e44d47d4b396cbba95174d45

Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production.

Autor: Alessandra Guidi, Cristiana Lalli, Roberto Gimmelli, Emanuela Nizi, Matteo Andreini, Nadia Gennari, Fulvio Saccoccia, Steven Harper, Alberto Bresciani, Giovina Ruberti

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 10, p e0005994 (2017)

Schistosomiasis, one of the most prevalent neglected parasitic diseases affecting humans and animals, is caused by the Platyhelminthes of the genus Schistosoma. Schistosomes are the only trematodes to have evolved sexual dimorphism and the constant p

Externí odkaz: https://doaj.org/article/bacaa2ac7d364a01a33cfbf94adc8cb1

The FHP01 DDX3X Helicase Inhibitor Exerts Potent Anti-Tumor Activity In Vivo in Breast Cancer Pre-Clinical Models

Autor: Lorenzo Franci, Matteo Andreini, Alessia Tarditi, Lisa Gherardini, Pierpaolo Calandro, Adele Boccuto, Vincenzo Miragliotta, Francesco Imperatore, Mario Chiariello, Giovanni Inzalaco, Romina D'Aurizio

Publikováno v: Cancers, Vol 13, Iss 4830, p 4830 (2021)
Cancers
Cancers (Basel) 13 (2021). doi:10.3390/cancers13194830
info:cnr-pdr/source/autori:Gherardini L. (1); Inzalaco G. (1)(2)(3); Imperatore F. (1); D'aurizio R. (4); Franci L. (1)(2)(3); Miragliotta V. (5); Boccuto A. (3); Calandro P. (2); Andreini M. (6); Tarditi A. (6); Chiariello M.(1)(2)/titolo:The FHP01 DDX3X helicase inhibitor exerts potent anti-tumor activity in vivo in breast cancer pre-clinical models/doi:10.3390%2Fcancers13194830/rivista:Cancers (Basel)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:13
Volume 13
Issue 19

Simple Summary DDX3X has been repeatedly proven to exert pro-tumorigenic effects in breast cancer. An inhibitor of DDX3X helicase function, FHP01, exhibited very effective antiproliferative and tumor killing activity in vitro and in vivo against seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d2c5784fe84fcb2a8a7f7b2db5d9b9
https://doi.org/10.3390/cancers13194830

Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins

Autor: Alberto Bresciani, Alessio Sferrazza, Matteo Andreini, Steven J. Harper, Rita Graziani, Danilo Fabbrini, Emanuela Nizi, Giacomo Paonessa, Valentina Nardi, Nadia Gennari

Publikováno v: Bioorganicmedicinal chemistry letters. 28(9)

Falcipain-2 (FP2) is an essential enzyme in the lifecycle of malaria parasites such as Plasmodium falciparum, and its inhibition is viewed as an attractive mechanism of action for new anti-malarial agents. Selective inhibition of FP2 with respect to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed75866f82fe905ee5ae0e3c42fe3690
https://pubmed.ncbi.nlm.nih.gov/29615344

Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production

Autor: Roberto Gimmelli, Fulvio Saccoccia, Nadia Gennari, Emanuela Nizi, Cristiana Lalli, Alessandra Guidi, Matteo Andreini, Steven J. Harper, Alberto Bresciani, Giovina Ruberti

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 10, p e0005994 (2017)
PLoS Neglected Tropical Diseases

Schistosomiasis, one of the most prevalent neglected parasitic diseases affecting humans and animals, is caused by the Platyhelminthes of the genus Schistosoma. Schistosomes are the only trematodes to have evolved sexual dimorphism and the constant p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ade61dc0adb650126c6cc45fb2bd46f
http://europepmc.org/articles/PMC5646872?pdf=render