Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Matteo, Lunghi"'
Autor:
Nicolas Dos Santos Pacheco, Albert Tell i Puig, Amandine Guérin, Matthew Martinez, Bohumil Maco, Nicolò Tosetti, Estefanía Delgado-Betancourt, Matteo Lunghi, Boris Striepen, Yi-Wei Chang, Dominique Soldati-Favre
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract In Apicomplexa, rhoptry discharge is essential for invasion and involves an apical vesicle (AV) docking one or two rhoptries to a macromolecular secretory apparatus. Toxoplasma gondii is armed with 10–12 rhoptries and 5-6 microtubule-assoc
Externí odkaz:
https://doaj.org/article/db5a5f1efb7a45248abcc933162e7602
Autor:
Vanessa M. Howieson, Joy Zeng, Joachim Kloehn, Christina Spry, Chiara Marchetti, Matteo Lunghi, Emmanuel Varesio, Andrew Soper, Anthony G. Coyne, Chris Abell, Giel G. van Dooren, Kevin J. Saliba
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 22, Iss , Pp 1-8 (2023)
Toxoplasma gondii is a pervasive apicomplexan parasite that can cause severe disease and death in immunocompromised individuals and the developing foetus. The treatment of toxoplasmosis often leads to serious side effects and novel drugs and drug tar
Externí odkaz:
https://doaj.org/article/00b024bbf99f4341a185721a0ef4505e
Autor:
Matteo Lunghi, Joachim Kloehn, Aarti Krishnan, Emmanuel Varesio, Oscar Vadas, Dominique Soldati-Favre
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Coenzyme A (CoA) is an essential metabolite found in all organisms and its synthesis involves five conserved enzymatic steps and uses pantothenate (Pan) as a precursor. Here, Lunghi et al. examine the Pan synthesis pathway in Toxoplasma gondii and fi
Externí odkaz:
https://doaj.org/article/760ba6dad3434446ad5b05a1f7b99b8a
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Toxoplasma gondii is an intracellular apicomplexan parasite that relies on cyclic GMP (cGMP)-dependent signaling to trigger timely egress from host cells in response to extrinsic and intrinsic signals. A guanylate cyclase (GC) complex, conse
Externí odkaz:
https://doaj.org/article/58294d98d8b547c5b509829085fe8473
Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion
Autor:
Gaëlle Lentini, Rouaa Ben Chaabene, Oscar Vadas, Chandra Ramakrishnan, Budhaditya Mukherjee, Ved Mehta, Matteo Lunghi, Jonas Grossmann, Bohumil Maco, Rémy Visentin, Adrian B. Hehl, Volodymyr M. Korkhov, Dominique Soldati-Favre
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Host cell invasion by Toxoplasma gondii depends on the heavily phosphorylated RON complex, but the relevance and regulation of these modifications are not understood. Here, the authors identify the kinase RON13 as a key virulence factor, determine it
Externí odkaz:
https://doaj.org/article/b99ddeb7c5ca4acfb20ea9d41fb9e96c
Autor:
Alessia Possenti, Manlio Di Cristina, Chiara Nicastro, Matteo Lunghi, Valeria Messina, Federica Piro, Lorenzo Tramontana, Simona Cherchi, Mario Falchi, Lucia Bertuccini, Furio Spano
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
To gain access to the intracellular cytoplasmic niche essential for their growth and replication, apicomplexan parasites such as Toxoplasma gondii rely on the timely secretion of two types of apical organelles named micronemes and rhoptries. Rhoptry
Externí odkaz:
https://doaj.org/article/02bbb6fb6dc545be85a4f0c5f5693032
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010124 (2021)
The Apicomplexa phylum comprises thousands of distinct intracellular parasite species, including coccidians, haemosporidians, piroplasms, and cryptosporidia. These parasites are characterized by complex and divergent life cycles occupying a variety o
Externí odkaz:
https://doaj.org/article/c25c93579c3e4132ab0833a335ef8d0a
Publikováno v:
Metabolites, Vol 11, Iss 8, p 476 (2021)
Apicomplexan parasites are responsible for devastating diseases, including malaria, toxoplasmosis, and cryptosporidiosis. Current treatments are limited by emerging resistance to, as well as the high cost and toxicity of existing drugs. As obligate i
Externí odkaz:
https://doaj.org/article/0b77a06974a44493a2de37203db1df53
Autor:
Geetha Kannan, Manlio Di Cristina, Aric J. Schultz, My-Hang Huynh, Fengrong Wang, Tracey L. Schultz, Matteo Lunghi, Isabelle Coppens, Vern B. Carruthers
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Toxoplasma gondii is a ubiquitous pathogen that can cause encephalitis, congenital defects, and ocular disease. T. gondii has also been implicated as a risk factor for mental illness in humans. The parasite persists in the brain as slow-grow
Externí odkaz:
https://doaj.org/article/ae12df682df347df9a095dba059bb18f
Autor:
David, Smith, Matteo, Lunghi, Einar B, Olafsson, Olivia, Hatton, Manlio, Di Cristina, Vern B, Carruthers
Publikováno v:
Analytical chemistry.
It is estimated that more than 2 billion people are chronically infected with the intracellular protozoan parasite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ad35e48d7a485efaa2149a5e63a9bc5
https://pubmed.ncbi.nlm.nih.gov/36548400
https://pubmed.ncbi.nlm.nih.gov/36548400