Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Matteo, Iannacone"'
LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness
Autor:
Isabella Pallavicini, Teresa Maria Frasconi, Carlotta Catozzi, Elena Ceccacci, Silvia Tiberti, Dorothee Haas, Jule Samson, Christoph Heuser-Loy, Carina B. Nava Lauson, Marta Mangione, Elisa Preto, Alberto Bigogno, Eleonora Sala, Matteo Iannacone, Ciro Mercurio, Luca Gattinoni, Ignazio Caruana, Mirela Kuka, Luigi Nezi, Saverio Minucci, Teresa Manzo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The lysine-specific histone demethylase 1 A (LSD1) is involved in antitumor immunity; however, its role in shaping CD8 + T cell (CTL) differentiation and function remains largely unexplored. Here, we show that pharmacological inhibition of L
Externí odkaz:
https://doaj.org/article/79a6302e7fd8421489f3328a337cb7b0
Autor:
Anna H. Mooney, Sarah L. Draper, Olivia K. Burn, Regan J. Anderson, Benjamin J. Compton, Chingwen Tang, Kathryn J. Farrand, Pietro Di Lucia, Micol Ravà, Valeria Fumagalli, Leonardo Giustini, Elisa Bono, Dale I. Godfrey, William R. Heath, Weiming Yuan, Francis V. Chisari, Luca G. Guidotti, Matteo Iannacone, John Sidney, Alessandro Sette, Shivali A. Gulab, Gavin F. Painter, Ian F. Hermans
Publikováno v:
JHEP Reports, Vol 6, Iss 5, Pp 101038- (2024)
Background & Aims: Liver diseases resulting from chronic HBV infection are a significant cause of morbidity and mortality. Vaccines that elicit T-cell responses capable of controlling the virus represent a treatment strategy with potential for long-t
Externí odkaz:
https://doaj.org/article/ee2629abc47b4a819f89b5234ea4bfff
Autor:
Liat Stoler-Barak, Ethan Harris, Ayelet Peres, Hadas Hezroni, Mirela Kuka, Pietro Di Lucia, Amalie Grenov, Neta Gurwicz, Meital Kupervaser, Bon Ham Yip, Matteo Iannacone, Gur Yaari, John D. Crispino, Ziv Shulman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Class switch recombination (CSR) is a process by which B cells switch their immunoglobulin isotype and develop pathogen-eliminating antibodies. Here, the authors show that a protein kinase DYRK1A is required for protection from viral infection throug
Externí odkaz:
https://doaj.org/article/431be3cd018542aa832ba2a735ae482b
Autor:
Valeria Fumagalli, Pietro Di Lucia, Micol Ravà, Davide Marotta, Elisa Bono, Stefano Grassi, Lorena Donnici, Rolando Cannalire, Irina Stefanelli, Anastasia Ferraro, Francesca Esposito, Elena Pariani, Donato Inverso, Camilla Montesano, Serena Delbue, Stanley Perlman, Enzo Tramontano, Raffaele De Francesco, Vincenzo Summa, Luca G Guidotti, Matteo Iannacone
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 5, Pp n/a-n/a (2023)
Abstract Alongside vaccines, antiviral drugs are becoming an integral part of our response to the SARS‐CoV‐2 pandemic. Nirmatrelvir—an orally available inhibitor of the 3‐chymotrypsin‐like cysteine protease—has been shown to reduce the ri
Externí odkaz:
https://doaj.org/article/af6a4cf2e9764395b79666f9ed74a291
Autor:
Kami Pekayvaz, Alexander Leunig, Rainer Kaiser, Markus Joppich, Sophia Brambs, Aleksandar Janjic, Oliver Popp, Daniel Nixdorf, Valeria Fumagalli, Nora Schmidt, Vivien Polewka, Afra Anjum, Viktoria Knottenberg, Luke Eivers, Lucas E. Wange, Christoph Gold, Marieluise Kirchner, Maximilian Muenchhoff, Johannes C. Hellmuth, Clemens Scherer, Raquel Rubio-Acero, Tabea Eser, Flora Deák, Kerstin Puchinger, Niklas Kuhl, Andreas Linder, Kathrin Saar, Lukas Tomas, Christian Schulz, Andreas Wieser, Wolfgang Enard, Inge Kroidl, Christof Geldmacher, Michael von Bergwelt-Baildon, Oliver T. Keppler, Mathias Munschauer, Matteo Iannacone, Ralf Zimmer, Philipp Mertins, Norbert Hubner, Michael Hoelscher, Steffen Massberg, Konstantin Stark, Leo Nicolai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Infection with SARS-COV-2 can result in self-limited upper airway infection or progress to a more systemic inflammatory condition including pneumonic COVID-19. Here the authors utilise a multi-omics approach to interrogate the immune response of pati
Externí odkaz:
https://doaj.org/article/25f8c8382ab44535bbd9a714a216c8f8
Autor:
Alberto Grandi, Michele Tomasi, Irfan Ullah, Cinzia Bertelli, Teresa Vanzo, Silvia Accordini, Assunta Gagliardi, Ilaria Zanella, Mattia Benedet, Riccardo Corbellari, Gabriele Di Lascio, Silvia Tamburini, Elena Caproni, Lorenzo Croia, Micol Ravà, Valeria Fumagalli, Pietro Di Lucia, Davide Marotta, Eleonora Sala, Matteo Iannacone, Priti Kumar, Walther Mothes, Pradeep D. Uchil, Peter Cherepanov, Martino Bolognesi, Massimo Pizzato, Guido Grandi
Publikováno v:
Vaccines, Vol 11, Iss 10, p 1546 (2023)
The vaccination campaign against SARS-CoV-2 relies on the world-wide availability of effective vaccines, with a potential need of 20 billion vaccine doses to fully vaccinate the world population. To reach this goal, the manufacturing and logistic pro
Externí odkaz:
https://doaj.org/article/31e7e04a637f48159dd6c370e1aaebc2
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 1640-1655 (2020)
Leukocyte function-associated antigen 1 (LFA-1) is the most widely expressed member of the β2 integrin family of cell-cell adhesion molecules. Although LFA-1 is thought to regulate multiple aspects of T cell immunity, its role in the response of CD8
Externí odkaz:
https://doaj.org/article/f091faf694c34f37838f58697754d4a9
Autor:
Francesco Andreata, Camille Blériot, Pietro Di Lucia, Giorgia De Simone, Valeria Fumagalli, Xenia Ficht, Cristian Gabriel Beccaria, Mirela Kuka, Florent Ginhoux, Matteo Iannacone
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100831- (2021)
Summary: Here, we provide detailed protocols for the isolation of mouse Kupffer cells – the liver-resident macrophages – for phenotypic (e.g., via flow cytometry, mass cytometry, or RNA-sequencing) analyses or for functional experiments involving
Externí odkaz:
https://doaj.org/article/789fccb91ed1475794b87f517ec97729
Autor:
Ian Baudi, Masanori Isogawa, Federica Moalli, Masaya Onishi, Keigo Kawashima, Yuji Ishida, Chise Tateno, Yusuke Sato, Hideyoshi Harashima, Hiroyasu Ito, Tetsuya Ishikawa, Takaji Wakita, Matteo Iannacone, Yasuhito Tanaka
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009228 (2021)
Virus infection, such as hepatitis B virus (HBV), occasionally causes endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) is counteractive machinery to ER stress, and the failure of UPR to cope with ER stress results in cell death.
Externí odkaz:
https://doaj.org/article/e016bc46b1164d8e848ca52ceee39270
Autor:
Mirco Compagnone, Eleonora Pinto, Erika Salvatori, Lucia Lione, Antonella Conforti, Silvia Marchese, Micol Ravà, Kathryn Ryan, Yper Hall, Emma Rayner, Francisco J. Salguero, Jemma Paterson, Matteo Iannacone, Raffaele De Francesco, Luigi Aurisicchio, Fabio Palombo
Publikováno v:
Vaccines, Vol 10, Iss 8, p 1178 (2022)
The COVID-19 pandemic is entering a new era with the approval of many SARS-CoV-2 vaccines. In spite of the restoration of an almost normal way of life thanks to the immune protection elicited by these innovative vaccines, we are still facing high vir
Externí odkaz:
https://doaj.org/article/66b84d88d8474a12bacb290c702f7d51