Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Matteo, Dal Peraro"'
Autor:
Lucien F. Krapp, Fernando A. Meireles, Luciano A. Abriata, Jean Devillard, Sarah Vacle, Maria J. Marcaida, Matteo Dal Peraro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Protein design and engineering are evolving at an unprecedented pace leveraging the advances in deep learning. Current models nonetheless cannot natively consider non-protein entities within the design process. Here, we introduce a deep lear
Externí odkaz:
https://doaj.org/article/bcf26b6d459a4c4c8298fb3bc8cdbaba
Autor:
Simon J. Crouzet, Anja Maria Lieberherr, Kenneth Atz, Tobias Nilsson, Lisa Sach-Peltason, Alex T. Müller, Matteo Dal Peraro, Jitao David Zhang
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2872-2882 (2024)
Protein–ligand interactions (PLIs) determine the efficacy and safety profiles of small molecule drugs. Existing methods rely on either structural information or resource-intensive computations to predict PLI, casting doubt on whether it is possible
Externí odkaz:
https://doaj.org/article/706aaa4c8b7f494480f6a524cfbe1b08
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Proteins are essential molecular building blocks of life, responsible for most biological functions as a result of their specific molecular interactions. However, predicting their binding interfaces remains a challenge. In this study, we pre
Externí odkaz:
https://doaj.org/article/082cd95ef19544f996bec815b6afa158
Autor:
Benjamin Rothé, Yayoi Ikawa, Zhidian Zhang, Takanobu A Katoh, Eriko Kajikawa, Katsura Minegishi, Sai Xiaorei, Simon Fortier, Matteo Dal Peraro, Hiroshi Hamada, Daniel B Constam
Publikováno v:
PLoS Biology, Vol 21, Iss 9, p e3002302 (2023)
Organ laterality of vertebrates is specified by accelerated asymmetric decay of Dand5 mRNA mediated by Bicaudal-C1 (Bicc1) on the left side, but whether binding of this or any other mRNA to Bicc1 can be regulated is unknown. Here, we found that a CRI
Externí odkaz:
https://doaj.org/article/e4ddd114040a4c738aa6b08683c53627
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104145- (2022)
Summary: Evolution has found countless ways to transport material across cells and cellular compartments separated by membranes. Protein assemblies are the cornerstone for the formation of channels and pores that enable this regulated passage of mole
Externí odkaz:
https://doaj.org/article/1ba3cb1413b24eb1887285f214aae1b3
Autor:
Luciano A. Abriata, Matteo Dal Peraro
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2626-2636 (2021)
Continuous assessment of transferable forcefields for molecular simulations is essential to identify their weaknesses and direct improvement efforts. The latest efforts focused on better describing disordered proteins while retaining proper descripti
Externí odkaz:
https://doaj.org/article/08d7a5cef2064ac799ba0657c374f6d8
Publikováno v:
CHIMIA, Vol 76, Iss 1-2 (2022)
moleculARweb (https://molecularweb.epfl.ch) began as a website for education and outreach in chemistry and structural biology through augmented reality (AR) content that runs in the web browsers of regular devices like smartphones, tablets, and compu
Externí odkaz:
https://doaj.org/article/7e25e37711854df1927b09187ebd3f9c
Autor:
Daniel P. Duarte, Allan J. Lamontanara, Giuseppina La Sala, Sukyo Jeong, Yoo-Kyoung Sohn, Alejandro Panjkovich, Sandrine Georgeon, Tim Kükenshöner, Maria J. Marcaida, Florence Pojer, Marco De Vivo, Dmitri Svergun, Hak-Sung Kim, Matteo Dal Peraro, Oliver Hantschel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Constitutive Btk signaling drives several B-cell cancers. Here the authors demonstrate key allosteric intramolecular interactions between the SH2 domain and the kinase domain of Btk, and propose an alternative approach for inhibition of both wild-typ
Externí odkaz:
https://doaj.org/article/35d89457e02f4b24aac8c29d22647799
Autor:
Chan Cao, Nuria Cirauqui, Maria Jose Marcaida, Elena Buglakova, Alice Duperrex, Aleksandra Radenovic, Matteo Dal Peraro
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Aerolysin pores have potential to improve the accuracy of DNA sequencing and single-molecule proteomics. Here, the authors rationally design a set of mutated pores to achieve a more accurate detection of peptides and nucleic acids.
Externí odkaz:
https://doaj.org/article/27165b7a4d1542c79d4bf6e6931d454d
BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy
Autor:
Sandra Donkervoort, Niklas Krause, Mykola Dergai, Pomi Yun, Judith Koliwer, Svetlana Gorokhova, Janelle Geist Hauserman, Beryl B Cummings, Ying Hu, Rosemarie Smith, Prech Uapinyoying, Vijay S Ganesh, Partha S Ghosh, Kristin G Monaghan, Seby L Edassery, Pia E Ferle, Sarah Silverstein, Katherine R Chao, Molly Snyder, Sara Ellingwood, Diana Bharucha‐Goebel, Susan T Iannaccone, Matteo Dal Peraro, A Reghan Foley, Jeffrey N Savas, Véronique Bolduc, Dirk Fasshauer, Carsten G Bönnemann, Michael Schwake
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 12, Pp n/a-n/a (2021)
Abstract BET1 is required, together with its SNARE complex partners GOSR2, SEC22b, and Syntaxin‐5 for fusion of endoplasmic reticulum‐derived vesicles with the ER‐Golgi intermediate compartment (ERGIC) and the cis‐Golgi. Here, we report three
Externí odkaz:
https://doaj.org/article/36e02f0c64b8417881fabf19320857cf