Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting.

Autor: Sullivan MR; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Mattaini KR; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Dennstedt EA; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Nguyen AA; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Sivanand S; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Reilly MF; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Meeth K; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Muir A; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Darnell AM; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Bosenberg MW; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA; Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA., Lewis CA; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Vander Heiden MG; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02139, USA. Electronic address: mvh@mit.edu.

Publikováno v: Cell metabolism [Cell Metab] 2019 Jun 04; Vol. 29 (6), pp. 1410-1421.e4. Date of Electronic Publication: 2019 Mar 21.

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation.

Autor: Mattaini KR; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA ; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA., Brignole EJ; Department of Chemistry Massachusetts Institute of Technology, Cambridge, MA 02139 USA ; Howard Hughes Medical Institute Massachusetts Institute of Technology, Cambridge, MA 02139 USA., Kini M; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA ; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA., Davidson SM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA ; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA., Fiske BP; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA ; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA., Drennan CL; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA ; Department of Chemistry Massachusetts Institute of Technology, Cambridge, MA 02139 USA ; Howard Hughes Medical Institute Massachusetts Institute of Technology, Cambridge, MA 02139 USA., Vander Heiden MG; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA ; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA ; Dana-Farber Cancer Institute, Boston, MA 02215 USA ; Broad Institute, Cambridge, MA 02139 USA.

Publikováno v: Cancer & metabolism [Cancer Metab] 2015 Apr 29; Vol. 3, pp. 5. Date of Electronic Publication: 2015 Apr 29 (Print Publication: 2015).

BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane.

Autor: Alsarraj J; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America., Faraji F, Geiger TR, Mattaini KR, Williams M, Wu J, Ha NH, Merlino T, Walker RC, Bosley AD, Xiao Z, Andresson T, Esposito D, Smithers N, Lugo D, Prinjha R, Day A, Crawford NP, Ozato K, Gardner K, Hunter KW

Publikováno v: PloS one [PLoS One] 2013 Nov 19; Vol. 8 (11), pp. e80746. Date of Electronic Publication: 2013 Nov 19 (Print Publication: 2013).

Cancer. Glycosylation to adapt to stress.

Autor: Mattaini KR; Koch Institute for Integrative Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Vander Heiden MG

Publikováno v: Science (New York, N.Y.) [Science] 2012 Aug 24; Vol. 337 (6097), pp. 925-6.

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.

Autor: Metallo CM; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA., Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G

Publikováno v: Nature [Nature] 2011 Nov 20; Vol. 481 (7381), pp. 380-4. Date of Electronic Publication: 2011 Nov 20.