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Elafin Reverses Intestinal Fibrosis by Inhibiting Cathepsin S-Mediated Protease-Activated Receptor 2.

Autor: Xie Y; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California; Department of Gastroenterology, The First Hospital of China Medical University, Shenyang City, Liaoning Province, China., Fontenot L; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California., Chupina Estrada A; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California., Nelson B; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California., Wang J; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California; Department of Gastroenterology, The First Hospital of China Medical University, Shenyang City, Liaoning Province, China., Shih DQ; F. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California., Ho W; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California., Mattai SA; Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California., Rieder F; Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio., Jensen DD; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, New York., Bunnett NW; Department of Molecular Pathobiology, Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, New York., Koon HW; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California. Electronic address: hkoon@mednet.ucla.edu.

Publikováno v: Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2022; Vol. 14 (4), pp. 841-876. Date of Electronic Publication: 2022 Jul 14.

High circulating elafin levels are associated with Crohn's disease-associated intestinal strictures.

Autor: Wang J; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, United States of America.; Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang City, Liaoning Province, China., Ortiz C; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, United States of America., Fontenot L; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, United States of America., Xie Y; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, United States of America.; Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang City, Liaoning Province, China., Ho W; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, United States of America., Mattai SA; Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, United States of America., Shih DQ; F. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America., Koon HW; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, United States of America.

Publikováno v: PloS one [PLoS One] 2020 Apr 14; Vol. 15 (4), pp. e0231796. Date of Electronic Publication: 2020 Apr 14 (Print Publication: 2020).

Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor.

Autor: Hoang-Yen Tran D; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Hoang-Ngoc Tran D; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Mattai SA; Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Sallam T; Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Ortiz C; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Lee EC; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Robbins L; Department of Medicine, Cedars-Sinai Medical Center, F. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Los Angeles, CA, USA., Ho S; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Lee JE; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Fisseha E; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Shieh C; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Sideri A; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Shih DQ; Department of Medicine, Cedars-Sinai Medical Center, F. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Los Angeles, CA, USA., Fleshner P; Department of Medicine, Cedars-Sinai Medical Center, F. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Los Angeles, CA, USA., McGovern DP; Department of Medicine, Cedars-Sinai Medical Center, F. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Los Angeles, CA, USA., Vu M; Department of Medicine, Cedars-Sinai Medical Center, F. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Los Angeles, CA, USA., Hing TC; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Bakirtzi K; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Cheng M; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Su B; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Law I; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Karagiannides I; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Targan SR; Department of Medicine, Cedars-Sinai Medical Center, F. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Los Angeles, CA, USA., Gallo RL; Division of Dermatology, Department of Medicine, the University of California San Diego, San Diego, CA, USA., Li Z; Division of Clinical Nutrition, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Koon HW; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA.

Publikováno v: International journal of obesity (2005) [Int J Obes (Lond)] 2016 Sep; Vol. 40 (9), pp. 1424-34. Date of Electronic Publication: 2016 May 10.