A Network of microRNAs Acts to Promote Cell Cycle Exit and Differentiation of Human Pancreatic Endocrine Cells

Autor: Jin, Wen, Mulas, Francesca, Gaertner, Bjoern, Sui, Yinghui, Wang, Jinzhao, Matta, Ileana, Zeng, Chun, Vinckier, Nicholas, Wang, Allen, Nguyen-Ngoc, Kim-Vy, Chiou, Joshua, Kaestner, Klaus H., Frazer, Kelly A., Carrano, Andrea C., Shih, Hung-Ping, Sander, Maike

Publikováno v: In iScience 22 November 2019 21:681-694

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Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes.

Autor: Wang G; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA., Chiou J; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA.; Biomedical Graduate Studies Program, University of California San Diego, La Jolla CA, USA., Zeng C; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA., Miller M; Center for Epigenomics, University of California San Diego, La Jolla CA, USA., Matta I; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA., Han JY; Center for Epigenomics, University of California San Diego, La Jolla CA, USA., Kadakia N; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA., Okino ML; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA., Beebe E; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA., Mallick M; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA., Camunas-Soler J; Department of Bioengineering, Stanford University, Stanford, USA., Dos Santos T; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Dai XQ; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Ellis C; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Hang Y; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.; Departments of Medicine and of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA., Kim SK; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.; Departments of Medicine and of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA, USA., MacDonald PE; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Kandeel FR; Department of Clinical Diabetes, Endocrinology & Metabolism, City of Hope, Duarte, CA, USA., Preissl S; Center for Epigenomics, University of California San Diego, La Jolla CA, USA.; Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Gaulton KJ; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla CA, USA., Sander M; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla CA, USA.; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla CA, USA.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 02. Date of Electronic Publication: 2023 Jan 02.