Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Matt X. G. Shao"'
Autor:
Jay A. Nadel, Matt X. G. Shao
Publikováno v:
Proceedings of the National Academy of Sciences. 102:767-772
Mucus hypersecretion is a prominent manifestation in patients with chronic inflammatory airway diseases. MUC5AC mucin is a major component of airway mucus, and its expression is modulated by a TNF-α-converting enzyme (TACE)–EGF receptor pathway th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d545f4d200e44b021c0cfbf0ff3cf8
https://doi.org/10.1073/pnas.0408932102
https://doi.org/10.1073/pnas.0408932102
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 287:L420-L427
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the U.S. Because cigarette smoking is so importantly implicated in the pathogenesis of COPD and because mucus hypersecretion plays such an important role in COPD, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ee26c09b6aac2498c5f428cb8ec225
https://doi.org/10.1152/ajplung.00019.2004
https://doi.org/10.1152/ajplung.00019.2004
Publikováno v:
Proceedings of the National Academy of Sciences. 100:11618-11623
Ectodomain shedding of epidermal growth factor receptor (EGFR) ligands [e.g., transforming growth factor type α (TGF-α)] and EGFR phosphorylation are implicated in mucin production in airway epithelial cells. Tumor necrosis factor α-converting enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eeaa7193c29cc2536d470737fbf287a
https://doi.org/10.1073/pnas.1534804100
https://doi.org/10.1073/pnas.1534804100
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 182(4)
Bacterial products (e.g., LPS) are viewed as critical stimuli in inflammation-associated cancer. Cyclooxygenase 2 (COX-2), a major effector of LPS, and EGFR, are key to carcinogenesis, notably in the hepatobiliary tract. In this study, we tested the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525e4f51cf53f5d9d3e27ec9bb43bb75
https://pubmed.ncbi.nlm.nih.gov/19201881
https://pubmed.ncbi.nlm.nih.gov/19201881
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 294(6)
Toll-like receptors (TLRs) are critical for the recognition of inhaled pathogens that deposit on the airway epithelial surface. The epithelial response to pathogens includes signaling cascades that activate the EGF receptor (EGFR). We hypothesized th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b801db8c70c0509956424e4e22db0f54
https://pubmed.ncbi.nlm.nih.gov/18375743
https://pubmed.ncbi.nlm.nih.gov/18375743
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 292(5)
Airways function as an innate immune organ against airborne bacteria that are inhaled and deposited in airways. One of the mechanisms of host defense is to recruit neutrophils into airways to clear the invaders. Airway epithelial cells produce neutro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c69fa61be7b6e7999968a4c6462b76b
https://pubmed.ncbi.nlm.nih.gov/17220369
https://pubmed.ncbi.nlm.nih.gov/17220369
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 177(12)
The surface of the airway epithelium represents a battleground in which the host intercepts signals from pathogens and activates epithelial defenses to combat infection. Wound repair is an essential function of the airway epithelium in response to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de288a545a16824cb497e02cadce8f4b
https://pubmed.ncbi.nlm.nih.gov/17142770
https://pubmed.ncbi.nlm.nih.gov/17142770
Autor:
Jay A. Nadel, Matt X. G. Shao
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 175(6)
Mucus hypersecretion is a prominent manifestation in patients with chronic inflammatory airway diseases and contributes to their morbidity and mortality by plugging airways and causing recurrent infections. Human neutrophil elastase (HNE) exists in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75145c1852b17597c71588139d41d447
https://pubmed.ncbi.nlm.nih.gov/16148149
https://pubmed.ncbi.nlm.nih.gov/16148149