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Akademický článek

AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis

Autor: Matt Teater, Pilar M. Dominguez, David Redmond, Zhengming Chen, Daisuke Ennishi, David W. Scott, Luisa Cimmino, Paola Ghione, Jayanta Chaudhuri, Randy D. Gascoyne, Iannis Aifantis, Giorgio Inghirami, Olivier Elemento, Ari Melnick, Rita Shaknovich

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

In diffuse large B-cell lymphoma (DLBCL) increased epigenetic heterogeneity in the form of cytosine methylation is known to link to a poor clinical outcome. Here, the authors show that AICDA, an enzyme required for DLBCL pathogenesis, increases cytos

Externí odkaz: https://doaj.org/article/2ab5189f12dc4d89ac687ffb7d5bf306

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Akademický článek

EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop

Autor: Wendy Béguelin, Martín A. Rivas, María T. Calvo Fernández, Matt Teater, Alberto Purwada, David Redmond, Hao Shen, Matt F. Challman, Olivier Elemento, Ankur Singh, Ari M. Melnick

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)

The histone methyltransferase EZH2 silences genes by generating H3K27me3 marks. Here the authors use a 3D GC organoid and show EZH2 mediates germinal centre (GC) formation through epigenetic silencing of CDKN1A and release of cell cycle checkpoints.

Externí odkaz: https://doaj.org/article/3b2ffd3bcb4b423ea05a96db979141c5

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Akademický článek

DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID

Autor: Pilar M. Dominguez, Matt Teater, Nyasha Chambwe, Matthias Kormaksson, David Redmond, Jennifer Ishii, Bao Vuong, Jayanta Chaudhuri, Ari Melnick, Aparna Vasanthakumar, Lucy A. Godley, F. Nina Papavasiliou, Olivier Elemento, Rita Shaknovich

Publikováno v: Cell Reports, Vol 12, Iss 12, Pp 2086-2098 (2015)

Changes in DNA methylation are required for the formation of germinal centers (GCs), but the mechanisms of such changes are poorly understood. Activation-induced cytidine deaminase (AID) has been recently implicated in DNA demethylation through its d

Externí odkaz: https://doaj.org/article/e80a1f8936c04aaebdd53dba9f89cc92

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Akademický článek

The BCL6 RD2 Domain Governs Commitment of Activated B Cells to Form Germinal Centers

Autor: Chuanxin Huang, David G. Gonzalez, Christine M. Cote, Yanwen Jiang, Katerina Hatzi, Matt Teater, Kezhi Dai, Timothy Hla, Ann M. Haberman, Ari Melnick

Publikováno v: Cell Reports, Vol 8, Iss 5, Pp 1497-1508 (2014)

To understand how the Bcl6 transcriptional repressor functions in the immune system, we disrupted its RD2 repression domain in mice. Bcl6RD2MUT mice exhibit a complete loss of germinal center (GC) formation but retain normal extrafollicular responses

Externí odkaz: https://doaj.org/article/1ed162acc18c444ea8b0a2f5b7b9e0c9

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Akademický článek

CTCF Haploinsufficiency Destabilizes DNA Methylation and Predisposes to Cancer

Autor: Christopher J. Kemp, James M. Moore, Russell Moser, Brady Bernard, Matt Teater, Leslie E. Smith, Natalia A. Rabaia, Kay E. Gurley, Justin Guinney, Stephanie E. Busch, Rita Shaknovich, Victor V. Lobanenkov, Denny Liggitt, Ilya Shmulevich, Ari Melnick, Galina N. Filippova

Publikováno v: Cell Reports, Vol 7, Iss 4, Pp 1020-1029 (2014)

Epigenetic alterations, particularly in DNA methylation, are ubiquitous in cancer, yet the molecular origins and the consequences of these alterations are poorly understood. CTCF, a DNA-binding protein that regulates higher-order chromatin organizati

Externí odkaz: https://doaj.org/article/48463119a5594710b0d33483242f11b5

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