Challenges in Lipidomics Biomarker Identification: Avoiding the Pitfalls and Improving Reproducibility

Autor: Johanna von Gerichten, Kyle Saunders, Melanie J. Bailey, Lee A. Gethings, Anthony Onoja, Nophar Geifman, Matt Spick

Publikováno v: Metabolites, Vol 14, Iss 8, p 461 (2024)

Identification of features with high levels of confidence in liquid chromatography–mass spectrometry (LC–MS) lipidomics research is an essential part of biomarker discovery, but existing software platforms can give inconsistent results, even from

Externí odkaz: https://doaj.org/article/f69f122041d04a2091a6a3e4389abb2e

An integrated analysis and comparison of serum, saliva and sebum for COVID-19 metabolomics

Autor: Matt Spick, Holly-May Lewis, Cecile F. Frampas, Katie Longman, Catia Costa, Alexander Stewart, Deborah Dunn-Walters, Danni Greener, George Evetts, Michael J. Wilde, Eleanor Sinclair, Perdita E. Barran, Debra J. Skene, Melanie J. Bailey

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract The majority of metabolomics studies to date have utilised blood serum or plasma, biofluids that do not necessarily address the full range of patient pathologies. Here, correlations between serum metabolites, salivary metabolites and sebum l

Externí odkaz: https://doaj.org/article/d7459a4b37354ec385c826633226feda

Metabolomics Markers of COVID-19 Are Dependent on Collection Wave

Autor: Holly-May Lewis, Yufan Liu, Cecile F. Frampas, Katie Longman, Matt Spick, Alexander Stewart, Emma Sinclair, Nora Kasar, Danni Greener, Anthony D. Whetton, Perdita E. Barran, Tao Chen, Deborah Dunn-Walters, Debra J. Skene, Melanie J. Bailey

Publikováno v: Metabolites, Vol 12, Iss 8, p 713 (2022)

The effect of COVID-19 infection on the human metabolome has been widely reported, but to date all such studies have focused on a single wave of infection. COVID-19 has generated numerous waves of disease with different clinical presentations, and th

Externí odkaz: https://doaj.org/article/224c85b36a6b4668a97a2efde4af8af6

Metabolomic Analysis of Plasma in Huntington’s Disease Transgenic Sheep (Ovis aries) Reveals Progressive Circadian Rhythm Dysregulation

Autor: Matt, Spick, Thomas P M, Hancox, Namrata R, Chowdhury, Benita, Middleton, Debra J, Skene, A Jennifer, Morton

Publikováno v: Journal of Huntington's Disease. 12:31-42

Background: Metabolic abnormalities have long been predicted in Huntington’s disease (HD) but remain poorly characterized. Chronobiological dysregulation has been described in HD and may include abnormalities in circadian-driven metabolism. Objecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0494fd0ce562c957668838f56479dc1
https://doi.org/10.3233/jhd-220552

A Novel Blood Proteomic Signature for Prostate Cancer

Autor: Ammara Muazzam, Matt Spick, Olivier N. F. Cexus, Bethany Geary, Fowz Azhar, Hardev Pandha, Agnieszka Michael, Rachel Reed, Sarah Lennon, Lee A. Gethings, Robert S. Plumb, Anthony D. Whetton, Nophar Geifman, Paul A. Townsend

Publikováno v: Cancers
Volume 15
Issue 4
Pages: 1051
Muazzam, A, Spick, M, Cexus, O N F, Geary, B, Azhar, F, Pandha, H, Michael, A, Reed, R, Lennon, S, Gethings, L A, Plumb, R S, Whetton, A D, Geifman, N & Townsend, P A 2023, ' A Novel Blood Proteomic Signature for Prostate Cancer ', Cancers, vol. 15, no. 4, 1051, pp. 1-17 . https://doi.org/10.3390/cancers15041051
Cancers, 2023, 15 (4), ⟨10.3390/cancers15041051⟩

International audience; Simple Summary Despite intensive research, effective tools for detection and monitoring of prostate cancer remain to be found. Prostate-specific antigen (PSA), commonly used in prostate cancer assessments, can lead to overdiag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ccea0670ba1ae3670e44b713a507b3