Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Matt Petrus"'
Autor:
Xinzhong Dong, Christian Schmedt, Yan Jiang, Matt Petrus, Mingmin Zhang, Haiping Wang, Bailong Xiao, Xiaoling Liu, Sisi Zheng, Qin Zheng
Publikováno v:
Cell Research. 29:95-109
Mammals possess a remarkable ability to sense subtle temperature deviations from the thermoneutral skin temperature of ~33 °C, which ensures precise warm sensation. However, the underlying mechanisms remain unclear. Here we show that STIM1, an endop
Autor:
Bryan A. Laffitte, Jingyuan Li, Matt Petrus, Linda Grimaud, Keiko Nonomura, James Kevin Mainquist, Stuart M. Cahalan, Jayanti Mathur, Van Lee, Emilie Vessières, Yan Xu, Fu-Li Xiang, Julie Favre, Ardem Patapoutian, Daniel Henrion, Jie Xu, Laura Bordone, Anthony P. Orth, Allain G. Francisco, Shu Chien, Shang Ma, Viktor Lukacs, Scott Hammack, John R. Walker, Michael Bandell
Publikováno v:
Cell, vol 173, iss 3
Xu, Jie; Mathur, Jayanti; Vessières, Emilie; Hammack, Scott; Nonomura, Keiko; Favre, Julie; et al.(2018). GPR68 Senses Flow and Is Essential for Vascular Physiology.. Cell, 173(3), 762-775.e16. doi: 10.1016/j.cell.2018.03.076. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/6bx4m237
The Journal of General Physiology
Cell
Cell, Elsevier, 2018, 173, pp.762-775.e16
Xu, Jie; Mathur, Jayanti; Vessières, Emilie; Hammack, Scott; Nonomura, Keiko; Favre, Julie; et al.(2018). GPR68 Senses Flow and Is Essential for Vascular Physiology.. Cell, 173(3), 762-775.e16. doi: 10.1016/j.cell.2018.03.076. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/6bx4m237
The Journal of General Physiology
Cell
Cell, Elsevier, 2018, 173, pp.762-775.e16
International audience; Mechanotransduction plays a crucial role in vascular biology. One example of this is the local regulation ofvascular resistance via flow-mediated dilation (FMD). Impairment of this process is a hallmark of endothelial dysfunct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b566ce433a17a215e87c728b68cf1e4
https://escholarship.org/uc/item/6bx4m237
https://escholarship.org/uc/item/6bx4m237
Autor:
Ardem Patapoutian, Seung-Hyun Woo, Takashi Miyamoto, Sanjeev S. Ranade, Andy D. Weyer, Zhaozhu Qiu, Adrienne E. Dubin, Yoshichika Baba, Matt Petrus, Cheryl L. Stucky, Kritika Reddy, Ellen A. Lumpkin
Publikováno v:
Nature. 509:622-626
How we sense touch remains fundamentally unknown. The Merkel cell-neurite complex is a gentle touch receptor in the skin that mediates slowly adapting responses of Aβ sensory fibres to encode fine details of objects. This mechanoreceptor complex was
Publikováno v:
Neuron. 64:498-509
SummaryTransient receptor potential A1 (TRPA1) ion channel senses a variety of noxious stimuli and is involved in nociception. Many TRPA1 agonists covalently modify the channel, which can lead to desensitization. The fate of modified TRPA1 and the me
Autor:
Badry Bursulaya, Michael Bandell, Hongzhen Hu, Manuela Schmidt, Matt Petrus, Jörg Grandl, Ardem Patapoutian
Publikováno v:
Nature Neuroscience. 11:1007-1013
Although certain ion channels can be gated by temperature, it is currently unknown how this occurs. Here, the authors identify regions of TRPV3 that are critical for heat sensation, yet independent of other channel gating mechanisms. Ion channels can
Autor:
Matt Petrus, Michael Bandell, Ardem Patapoutian, Anthony P. Orth, Sun Wook Hwang, Adrienne E. Dubin, Jayanti Mathur
Publikováno v:
Nature Neuroscience. 9:493-500
Menthol is a cooling compound derived from mint leaves and is extensively used as a flavoring chemical. Menthol activates transient receptor potential melastatin 8 (TRPM8), an ion channel also activated by cold, voltage and phosphatidylinositol-4,5-b
Autor:
Allain G. Francisco, Matt Petrus, James Kevin Mainquist, John N. Wood, A. J. Wilson, Adrienne E. Dubin, Sanjeev S. Ranade, Valérie Bégay, Rabih Moshourab, Christiane Wetzel, Ardem Patapoutian, Seung-Hyun Woo, Zhaozhu Qiu, Bertrand Coste, Gary R. Lewin, Jayanti Mathur, Kritika Reddy
Publikováno v:
Nature
Nature, Nature Publishing Group, 2014, 516 (7529), pp.121-125. ⟨10.1038/nature13980⟩
Nature, 2014, 516 (7529), pp.121-125. ⟨10.1038/nature13980⟩
Nature, Nature Publishing Group, 2014, 516 (7529), pp.121-125. ⟨10.1038/nature13980⟩
Nature, 2014, 516 (7529), pp.121-125. ⟨10.1038/nature13980⟩
The sense of touch provides critical information about our physical environment by transforming mechanical energy into electrical signals. It is postulated that mechanically activated cation channels initiate touch sensation, but the identity of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2fcad87702fb3d01711bb91e815ab8b
https://europepmc.org/articles/PMC4380172/
https://europepmc.org/articles/PMC4380172/
Autor:
Nicholas James Devereux, Anne-Marie D’Souza, Valerie Boissel, Vidal Agnes, Mark Nash, Ardem Patapoutian, Ryan West, J. Martin Verkuyl, Andrew M. Schumacher, Brian T. Masick, Victoria Head, H. Michael Petrassi, Rowan Stringer, Lisa Ann Rooney, Natalie Stoakley, Moh Panesar, David C. Tully, Jianmin Lao, Matt Petrus
Publikováno v:
Journal of medicinal chemistry. 57(12)
A high throughput screening campaign identified 5-(2-chlorophenyl)indazole compound 4 as an antagonist of the transient receptor potential A1 (TRPA1) ion channel with IC50 = 1.23 μM. Hit to lead medicinal chemistry optimization established the SAR a
Publikováno v:
Nature Communications. 2
Nitric oxide (NO) is an unstable signalling molecule synthesized de novo mainly from L-arginine by NO synthase (NOS) enzymes. Nitrite reduction can also produce NO, predominantly within body fluids (for example, saliva, sweat and blood plasma) and un
Autor:
Michael Zhao, Clifford J. Woolf, Colby A. Cook, Donato del Camino, Matt Petrus, Christopher M. Fanger, Marc D'Amours, Ardem Patapoutian, Michael Costigan, Sarah Murphy, Melissa Heiry, Neil Hayward, Nate Deering, Magdalene M. Moran, Gary J. Brenner, Jayhong A. Chong, Lee Barrett, Taryn J. Earley
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(45)
TRPA1 is a nonselective cation channel expressed by nociceptors. Although it is widely accepted that TRPA1 serves as a broad irritancy receptor for a variety of reactive chemicals, its role in cold sensation remains controversial. Here, we demonstrat