Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Matt Niederst"'
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/1168651eade84aa68bb9c377c9befbde
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently emerged as a key modality in drug d
Externí odkaz:
https://doaj.org/article/8f2eff537f564b01931321a688bb396a
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Fred Sigoillot, Scott Gleim, Marie-Therese Stachyra, Jason Thomas, Damien Begue, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Seth Carbonneau, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Bea Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Claudio R. Thoma
Targeted protein degradation (TPD) of neo-substrates with proteolysis targeting chimeras (PROTACs) or molecular glues has emerged as a key modality in exploring new biology as well as designing new drug candidates where catalytic inhibition is neithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b962ac1012caadf747a15217539d973e
https://doi.org/10.1101/2023.04.09.536153
https://doi.org/10.1101/2023.04.09.536153
Publikováno v:
Journal of Biological Chemistry. 286:39122-39129
The pro-survival kinase Akt requires phosphorylation at two conserved residues, the activation loop site (Thr-308) and the hydrophobic motif site (Ser-473), for maximal activation. Previous reports indicate that mTORC2 is necessary for phosphorylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d6f62e1f2416adb4be5dff05824639
https://doi.org/10.1074/jbc.m111.278747
https://doi.org/10.1074/jbc.m111.278747
Autor:
Haichuan Hu, Lecia Sequist, Zofia Piotrowska, Hillary Mulvey, Sundus Noeen, Patricia Hare, David Kodack, Aaron Hata, Matt Niederst, Cyril Benes, Jeff Engelman
Publikováno v:
Clinical Cancer Research. 24:B25-B25
This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR04) of the Conference Proceedings. Citation Format: Haichuan Hu, Lecia Sequist, Zofia Piotrowska, Hillary Mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac004e6b173e083ca0cb4c04234343e4
https://doi.org/10.1158/1557-3265.aacriaslc18-b25
https://doi.org/10.1158/1557-3265.aacriaslc18-b25
Autor:
Muhan Chen, Ksenya Cohen-Katsenelson, Gloria Reyes, John Brognard, Matt Niederst, Joshua D. Stender, Maya T. Kunkel, Emma Sierecki, Tianyan Gao, Lloyd C. Trotman, Christopher K. Glass, Dawid G. Nowak, Alexandra C. Newton
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 38
Growth factor receptor levels are aberrantly high in diverse cancers, driving the proliferation and survival of tumor cells. Understanding the molecular basis for this aberrant elevation has profound clinical implications. Here we show that the pleck
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a99ebb779e91bddbc219030d76e027
https://doi.org/10.1073/pnas.1404221111
https://doi.org/10.1073/pnas.1404221111
Autor:
John Brognard, Maya T. Kunkel, Gloria Reyes, Matt Niederst, Lloyd C. Trotman, Muhan Chen, Ksenya Cohen Katsenelson, Dawid G. Nowak, Alexandra C. Newton
Publikováno v:
The FASEB Journal. 28
Growth factor receptor levels are aberrantly high in diverse cancers, driving the proliferation and survival of tumor cells. Understanding the molecular basis for this aberrant elevation has profound clinical applications. Here we show that the PH do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ec9d9733d058256b12f24f334e63a7c
https://doi.org/10.1096/fasebj.28.1_supplement.802.19
https://doi.org/10.1096/fasebj.28.1_supplement.802.19
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cb41c9830ab89bf079696a3e6432cce
https://doi.org/10.1096/fasebj.22.1_supplement.1049.5
https://doi.org/10.1096/fasebj.22.1_supplement.1049.5