Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Matt K. Lee"'
Autor:
Changgong Li, Susan M Smith, Neil Peinado, Feng Gao, Wei Li, Matt K Lee, Beiyun Zhou, Saverio Bellusci, Gloria S Pryhuber, Hsin-Yi Henry Ho, Zea Borok, Parviz Minoo
Publikováno v:
Cells, Vol 9, Iss 2, p 384 (2020)
WNT5a is a mainly “non-canonical” WNT ligand whose dysregulation is observed in lung diseases such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and asthma. Germline deletion of Wnt5a disrupts embryonic lung
Externí odkaz:
https://doaj.org/article/8e952bc39d684b2baefe8fe97f7f247d
Autor:
Changgong Li, Neil Peinado, Susan M Smith, Jing Zhou, Feng Gao, GoleNaz Kohbodi, Beiyun Zhou, Matthew E Thornton, Brendan H Grubbs, Matt K Lee, Saverio Bellusci, Zea Borok, Ya-Wen Chen, Parviz Minoo
Publikováno v:
Stem Cells
Lung maturation is not limited to proper structural development but also includes differentiation and functionality of various highly specialized alveolar cell types. Alveolar type 1 (AT1s) cells occupy nearly 95% of the alveolar surface and are crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6415ad4011fb03f9f4afc37b52df3ac4
https://europepmc.org/articles/PMC9332903/
https://europepmc.org/articles/PMC9332903/
Autor:
Sha Webster, Matt K. Lee, Susan Smith, Changgong Li, Feng Gao, Jiang Duan, Helen Di, Navin Bhopal, Zea Borok, Neil Peinado, Chang-Yo Yang, Saverio Bellusci, Parviz Minoo, Gloria S. Pryhuber
Publikováno v:
Development
Postnatal alveolar formation is the most important and the least understood phase of lung development. Alveolar pathologies are prominent in neonatal and adult lung diseases. The mechanisms of alveologenesis remain largely unknown. We inactivated Pdg
Autor:
Baby Periyanayaki Muthusamy, Matt K. Lee, Rik Derynck, Yoko Katsuno, Amer M. Mirza, Erine H. Budi, Rosemary J. Akhurst, Susan Smith
Publikováno v:
PLoS Biology, Vol 13, Iss 12, p e1002325 (2015)
PLoS Biology
PLoS Biology
Epithelial–mesenchymal transition (EMT) is a normal cell differentiation event during development and contributes pathologically to carcinoma and fibrosis progression. EMT often associates with increased transforming growth factor-β (TGF-β) signa
Autor:
Rik Derynck, Marie C Hall, Jing Qing, David Warburton, Pierre S Lee, Susan Smith, Matt K. Lee, Cécile Pardoux
Publikováno v:
The EMBO Journal. 26:3957-3967
Erk1/Erk2 MAP kinases are key regulators of cell behaviour and their activation is generally associated with tyrosine kinase signalling. However, TGF-beta stimulation also activates Erk MAP kinases through an undefined mechanism, albeit to a much low
Dihydrotestosterone Potentiates EGF-Induced ERK Activation by Inducing SRC in Fetal Lung Fibroblasts
Lung maturation is regulated by interactions between mesenchymal and epithelial cells, and is delayed by androgens. Fibroblast–Type II cell communications are dependent on extracellular signal-regulated kinases (ERK) 1/2 activation by the ErbB rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9b783bafab77b96007ac74bd508460
https://europepmc.org/articles/PMC4091851/
https://europepmc.org/articles/PMC4091851/
Autor:
Matt K. Lee, David Warburton
Publikováno v:
Current Opinion in Pediatrics. 11:188-192
Recent molecular genetic and embryonic organ culture studies have implicated several novel regulatory processes in the coordination of lung development. Failure of pulmonary initiation results from interruptions of the sonic hedgehog/patched/Gli and
Autor:
David Warburton, Chenduen Hwang, Susan Smith, Pablo Bringas, Matt K. Lee, Jingsong Zhao, J.Denise Tefft
Publikováno v:
Pediatric Research. 44:850-859
Many of the signaling pathways regulating fetal lung mesenchymal cell proliferation are mediated by the Shc intracellular signaling proteins. Shc is expressed as three isoforms: 52 kD and 46 kD proteins (Shc 52 and Shc 46, respectively) translated fr
Publikováno v:
Developmental Biology. 194(2):182-195
Smad genes are recently identified intracellular effectors for receptor signaling in the BMP/activin/TGF-beta pathway. Since TGF-beta ligands are known to inhibit embryonic lung branching morphogenesis, we tested the hypothesis that Smad genes negati