Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Matt J. Barter"'
Autor:
Rodolfo Gómez, Matt J. Barter, Ana Alonso-Pérez, Andrew J. Skelton, Carole Proctor, Gabriel Herrero-Beaumont, David A. Young
Publikováno v:
Biological Research, Vol 56, Iss 1, Pp 1-17 (2023)
Abstract Background Knowledge about regulating transcription factors (TFs) for osteoblastogenesis from mesenchymal stem cells (MSCs) is limited. Therefore, we investigated the relationship between genomic regions subject to DNA-methylation changes du
Externí odkaz:
https://doaj.org/article/d05b15634531419289d5e5b613947160
Autor:
Matt J. Barter, Andrew Butcher, Hui Wang, Dimitra Tsompani, Martin Galler, Ellen L. Rumsby, Kirsty L. Culley, Ian M. Clark, David A. Young
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Elevated pro-inflammatory signalling coupled with catabolic metalloproteinase expression is a common feature of arthritis, leading to cartilage damage, deterioration of the joint architecture and the associated pain and immobility. Counterin
Externí odkaz:
https://doaj.org/article/b236eceb3e654db68f7631e1b411f044
Autor:
Dan J. Hayman, Tamara Modebadze, Sarah Charlton, Kat Cheung, Jamie Soul, Hua Lin, Yao Hao, Colin G. Miles, Dimitra Tsompani, Robert M. Jackson, Michael D. Briggs, Katarzyna A. Piróg, Ian M. Clark, Matt J. Barter, Gavin J. Clowry, Fiona E. N. LeBeau, David A. Young
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract MicroRNAs are non-coding RNAs that act to downregulate the expression of target genes by translational repression and degradation of messenger RNA molecules. Individual microRNAs have the ability to specifically target a wide array of gene t
Externí odkaz:
https://doaj.org/article/b74a1a1210eb465eb49f8ba80fb52c10
Publikováno v:
F1000Research, Vol 8 (2019)
Metalloproteinases remain important players in arthritic disease, in part because members of this large enzymatic family, namely matrix metalloproteinase-1 (MMP-1) and MMP-13, are responsible for the irreversible degradation of articular cartilage co
Externí odkaz:
https://doaj.org/article/0564a8575466481c86baa31437de9133
Publikováno v:
Osteoarthritis and Cartilage. 30:216-225
Summary Objective In this review, we have highlighted the advances over the past year in genetics, genomics and epigenetics in the field of osteoarthritis (OA). Methods A literature search of PubMed was performed using the criteria: "osteoarthritis"
Publikováno v:
Annals of the Rheumatic Diseases
ObjectivesTo collate the genes experimentally modulated in animal models of osteoarthritis (OA) and compare these data with OA transcriptomics data to identify potential therapeutic targets.MethodsPubMed searches were conducted to identify publicatio
Autor:
Raluca Pais, Rachel Ostroff, Stephen Harrison, Lars Friis Mikkelsen, Elisabeth Erhardtsen, Sudha Shankar, Kimmo Porthan, Jérôme Boursier, Antonia Sinisi, Michael Kalutkiewicz, Sven Francque, Miljen Martic, Vanessa Pellegrinelli, Phil N. Newsome, Guido Hanauer, Hannele Yki-Järvinen, Rebecca Darlay, Joel Myers, Carla Yunis, Salvatore Petta, Mette Skalshøi Kjær, Pablo Ortiz, Ann K. Daly, James H. Clark, Dina Tiniakos, Yasaman Vali, Hadi Zafarmand, Matej Orešič, Maurizio Parola, Estelle Sandt, Lori L. Jennings, Matt Kelly, Tuulia Hyötyläinen, Detlef Schuppan, Céline Fournier, Chiara Rosso, Diane E. Shevell, Maria Manuela Tonini, Paul Hockings, Aidan McGlinchey, Salma Akhtar, Mette Juul Fisker, Morten A. Karsdal, Diane Whalley, Melissa R. Miller, Aldo Trylesinski, Mattias Ekstedt, Stefan Neubauer, Jeremy M. Palmer, Partho Sen, Michael Pavlides, Per Qvist, Isabel Fernández, Luca Miele, Fabio Marra, Stergios Kechagias, Richard Torstenson, Katherine Johnson, Jean-François Dufour, Elisabetta Bugianesi, M. Julia Brosnan, George V. Papatheodoridis, Kay M. Pepin, Daniel Guldager Kring Rasmussen, Henrik Landgren, Rachel Queen, Simon Cockell, Michael Allison, Patrick M.M. Bossuyt, Rocío Gallego-Durán, Christian Rosenquist, Leigh Alexander, Elizabeth Shumbayawonda, Michele Vacca, Antonio Vidal-Puig, David Wenn, Rémy Hanf, Oscar Millet, Michalina Zatorska, R. Myers, José M. Mato, Jenny Lee, Theresa Tuthill, James Twiss, Ramy Younes, Peter Leary, Lynda Doward, Kristy Wonders, Guruprasad P. Aithal, Sarah Charlton, Vlad Ratziu, Cecília M. P. Rodrigues, Christian Trautwein, Helena Cortez-Pinto, Gideon Ho, Matt J. Barter, Judith Ertle, Jörn M. Schattenberg, Maria-Magdalena Balp, Yang-Lin Liu, Clifford A. Brass, Olivier Govaere, Amalia Gastaldelli, Sergio Rodriguez Cuenca, Pierre Chaumat, Fiona Oakley, Luca Valenti, Simon J. Cockell, Saskia W.C. van Mil, Ferenc E. Mózes, Andreas Geier, Timothy Hardy, Pierre Bedossa, Andrea Dennis, Richard L. Ehman, Charlotte Erpicum, Karine Clément, Jeremy F. L. Cobbold, Christopher P. Day, Rajarshi Banerjee, Manuel Romero-Gómez, Quentin M. Anstee, Adriaan G. Holleboom, Heather J. Cordell, Kevin L. Duffin, Diana Julie Leeming
Publikováno v:
JHEP Reports, 4(2):100409. Elsevier
JHEP Reports
JHEP Reports, Vol 4, Iss 2, Pp 100409-(2022)
JHEP reports 4(2), 100409 (2022). doi:10.1016/j.jhepr.2021.100409
JHEP Reports
JHEP Reports, Vol 4, Iss 2, Pp 100409-(2022)
JHEP reports 4(2), 100409 (2022). doi:10.1016/j.jhepr.2021.100409
Background & Aims Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed to profile miRNAs comprehensively at all NAFLD stages. Methods We profiled 2,083 ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c39a3a5921e0d464a7b2b93c40ef52c
https://pure.amc.nl/en/publications/increased-serum-mir193a5p-during-nonalcoholic-fatty-liver-disease-progression(bd6dd66c-d686-4b4d-be46-956a848f1f3b).html
https://pure.amc.nl/en/publications/increased-serum-mir193a5p-during-nonalcoholic-fatty-liver-disease-progression(bd6dd66c-d686-4b4d-be46-956a848f1f3b).html
Autor:
Michael D. Briggs, Robert M. Jackson, Dimitra Tsompani, Yao Hao, Katarzyna A. Piróg, Tamara Modebadze, Jamie Soul, Gavin J. Clowry, David Young, Fiona E. N. LeBeau, Sarah Charlton, Colin G. Miles, Ian M. Clark, Dan J. Hayman, Kathleen Cheung, Hua Lin, Matt J. Barter
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
MicroRNAs are non-coding RNAs that act to downregulate the expression of target genes by translational repression and degradation of messenger RNA molecules. Individual microRNAs have the ability to specifically target a wide array of gene transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d418215007155d56e894db76e03d3933
https://ueaeprints.uea.ac.uk/id/eprint/80121/
https://ueaeprints.uea.ac.uk/id/eprint/80121/
Autor:
Rodolfo Gómez, David Young, Hannah R Elliott, Louise N. Reynard, Andrew J. Skelton, Julia Falk, Matt J. Barter, Kathleen Cheung, Catherine Bui
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-58093-5⟩
Barter, M J, Bui, C, Cheung, K, Falk, J, Gómez, R, Skelton, A J, Elliott, H R, Reynard, L N & Young, D A 2020, ' DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions ', Scientific Reports, vol. 10, 1169 (2020) . https://doi.org/10.1038/s41598-020-58093-5
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-58093-5⟩
Barter, M J, Bui, C, Cheung, K, Falk, J, Gómez, R, Skelton, A J, Elliott, H R, Reynard, L N & Young, D A 2020, ' DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions ', Scientific Reports, vol. 10, 1169 (2020) . https://doi.org/10.1038/s41598-020-58093-5
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Regulation of transcription occurs in a cell type specific manner orchestrated by epigenetic mechanisms including DNA methylation. Methylation changes may also play a key role in lineage specification during stem cell differentiation. To further our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259d354a28bf7d8693992d9cae8e041f
https://hal.univ-lorraine.fr/hal-02949383
https://hal.univ-lorraine.fr/hal-02949383
Autor:
Ian M. Clark, Lingzi Niu, David Young, Tamas Dalmay, L. Le, Matt J. Barter, Tracey E. Swingler
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
MicroRNAs have been shown to play a role in cartilage development, homeostasis and breakdown during osteoarthritis. We previously identified miR-3085 in humans as a chondrocyte-selective microRNA, however it could not be detected by Northern blot. Th