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Autor:
Rajat Mohindra, Jianfeng Xu, Kai Wu, Yanmei Xu, Paul D. Thompson, Benjamin van Hecke, Matt J. B. Davies, Aarti Patel, Jan Hilpert, Gary Collins
Publikováno v:
The Journal of Clinical Pharmacology. 55:505-511
This open label drug-drug interaction (DDI) study investigated the effect of a strong CYP3A inhibitor ketoconazole on the PK and safety profile of GSK239512. To mitigate the tolerability concerns of high GSK239512 exposures resulting from CYP3A inhib